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A7NKQ5 (A7NKQ5_ROSCS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:Rcas_1987
OrganismRoseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP] EMBL ABU58075.1
Taxonomic identifier383372 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region120 – 12895-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1241Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A7NKQ5 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 09E350C3AE57AE59

FASTA21022,327
        10         20         30         40         50         60 
MTTDIAYEIA ATLLEAGALL IRPREPFIFA SGLRSPIYCD NRMLLGDVAA RRIVTRGFAA 

        70         80         90        100        110        120 
QCADAQVVAG PATGGIAWAA WVAEALSIPM AYVRSGAKGH GRGRQVEGAT VRDRRVALLE 

       130        140        150        160        170        180 
DTVSTGESAL QAADALRAEG ALVTHCVCIF TWGWADTEAR FAAAHLHLVP LATLPAVLDV 

       190        200        210 
AQRTGRLTPE ARALVESWAA NPRAWMPPEA

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References

[1]"Complete sequence of Roseiflexus castenholzii DSM 13941."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000804 Genomic DNA. Translation: ABU58075.1.
RefSeqYP_001432093.1. NC_009767.1.

3D structure databases

ProteinModelPortalA7NKQ5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7NKQ5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5539465.
GenomeReviewsGene locus Rcas_1987 in contig CP000804_GR.
KEGGrca:Rcas_1987.
PATRIC23342349. VBIRosCas91182_2243.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBCLSK973736.

Enzyme and pathway databases

BioCycRCAS383372:RCAS_1987-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7NKQ5_ROSCS
AccessionPrimary (citable) accession number: A7NKQ5
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info