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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (Rcas_4199)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:G1G9S-1939-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:Rcas_1843
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000000263 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000764641 – 249Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST249

Proteomic databases

PRIDEiA7NKB4

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_1843

Structurei

3D structure databases

ProteinModelPortaliA7NKB4
SMRiA7NKB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T2D Bacteria
COG0152 LUCA
HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG
OrthoDBiPOG091H02H7

Family and domain databases

HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
PROSITEiView protein in PROSITE
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A7NKB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLGEKLTEG KTKIVYAHPN DPTLAIIIHK DGISAGDGAR RHIIPGKGAL
60 70 80 90 100
SGRTTANVFT MLNHAGVATH FVAAPEPTVM IVRRCVMIPL EVVNRRIATG
110 120 130 140 150
SYIRRHPDVA EGTRFDPPLL EFFLKDDARH DPQISPEEIV AQGIASADEV
160 170 180 190 200
EQLASESRRV FLLIEEAWAA QDIVLCDLKI EFGRDASGAL VVADVIDNDS
210 220 230 240
WRIWPGGMKE RMLDKQVYRN MPVVTDDGLE QVRRLYEEVA HRTDAWVNR
Length:249
Mass (Da):27,767
Last modified:October 2, 2007 - v1
Checksum:i12C85DC31B6C2ACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA Translation: ABU57934.1
RefSeqiWP_012120359.1, NC_009767.1

Genome annotation databases

EnsemblBacteriaiABU57934; ABU57934; Rcas_1843
KEGGirca:Rcas_1843

Similar proteinsi

Entry informationi

Entry nameiPUR7_ROSCS
AccessioniPrimary (citable) accession number: A7NKB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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