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A7NHU9 (A7NHU9_ROSCS) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NAD kinase HAMAP-Rule MF_00361

EC=2.7.1.23 HAMAP-Rule MF_00361
Alternative name(s):
ATP-dependent NAD kinase HAMAP-Rule MF_00361
Gene names
Name:nadK HAMAP-Rule MF_00361
Ordered Locus Names:Rcas_0932 EMBL ABU57046.1
OrganismRoseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP] EMBL ABU57046.1
Taxonomic identifier383372 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361 SAAS SAAS002504

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361 SAAS SAAS002504.

Sequence similarities

Belongs to the NAD kinase family. HAMAP-Rule MF_00361

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding62 – 632NAD By similarity HAMAP-Rule MF_00361
Nucleotide binding137 – 1382NAD By similarity HAMAP-Rule MF_00361

Sites

Active site621Proton acceptor By similarity HAMAP-Rule MF_00361
Binding site671NAD By similarity HAMAP-Rule MF_00361
Binding site1481NAD By similarity HAMAP-Rule MF_00361
Binding site1651NAD By similarity HAMAP-Rule MF_00361
Binding site1671NAD By similarity HAMAP-Rule MF_00361
Binding site2021NAD; via carbonyl oxygen By similarity HAMAP-Rule MF_00361

Sequences

Sequence LengthMass (Da)Tools
A7NHU9 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 2AE8BC4DA153CFE6

FASTA27830,268
        10         20         30         40         50         60 
MKPIKRVAII FNPYSDESLH MSGEVAGWLT ERSIQVWRGV SHEGRAQHAV DHTDLVLALG 

        70         80         90        100        110        120 
GDGTVLRAAR LAIPSGVPVL PVALGRLNFM AELEPSTLYQ GLEDMLAGRF WLDSRTLVEA 

       130        140        150        160        170        180 
TVLRADGITV SPILALNEII VARGDINRTV LVDVEIYDAR LTTYHADGVI VASATGSTAY 

       190        200        210        220        230        240 
ALAAGGPIID PRSTALVLVP VAAHLTNVPS LVLHEDAVVT LTLQSRHPAG FSADGHDHIA 

       250        260        270 
LHEGDRVIVR RSQRCCTFAR VYPQSTFYAR MMQRLRRE 

« Hide

References

[1]"Complete sequence of Roseiflexus castenholzii DSM 13941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000804 Genomic DNA. Translation: ABU57046.1.
RefSeqYP_001431064.1. NC_009767.1.

3D structure databases

ProteinModelPortalA7NHU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING383372.Rcas_0932.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU57046; ABU57046; Rcas_0932.
GeneID5538398.
KEGGrca:Rcas_0932.
PATRIC23339991. VBIRosCas91182_1075.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAVLDPGDW.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycRCAS383372:GH89-942-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA7NHU9_ROSCS
AccessionPrimary (citable) accession number: A7NHU9
Entry history
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)