SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7NHU9

- A7NHU9_ROSCS

UniProt

A7NHU9 - A7NHU9_ROSCS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NAD kinase
Gene
nadK, Rcas_0932
Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotations

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptor By similarityUniRule annotation
Binding sitei67 – 671NAD By similarityUniRule annotation
Binding sitei148 – 1481NAD By similarityUniRule annotation
Binding sitei165 – 1651NAD By similarityUniRule annotation
Binding sitei167 – 1671NAD By similarityUniRule annotation
Binding sitei202 – 2021NAD; via carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 632NAD By similarityUniRule annotation
Nucleotide bindingi137 – 1382NAD By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, NADUniRule annotationSAAS annotations, NADPUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:GH89-942-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Rcas_0932Imported
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)Imported
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_0932.

Structurei

3D structure databases

ProteinModelPortaliA7NHU9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiVLDPGDW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NHU9-1 [UniParc]FASTAAdd to Basket

« Hide

MKPIKRVAII FNPYSDESLH MSGEVAGWLT ERSIQVWRGV SHEGRAQHAV    50
DHTDLVLALG GDGTVLRAAR LAIPSGVPVL PVALGRLNFM AELEPSTLYQ 100
GLEDMLAGRF WLDSRTLVEA TVLRADGITV SPILALNEII VARGDINRTV 150
LVDVEIYDAR LTTYHADGVI VASATGSTAY ALAAGGPIID PRSTALVLVP 200
VAAHLTNVPS LVLHEDAVVT LTLQSRHPAG FSADGHDHIA LHEGDRVIVR 250
RSQRCCTFAR VYPQSTFYAR MMQRLRRE 278
Length:278
Mass (Da):30,268
Last modified:October 2, 2007 - v1
Checksum:i2AE8BC4DA153CFE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU57046.1.
RefSeqiWP_012119476.1. NC_009767.1.
YP_001431064.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU57046; ABU57046; Rcas_0932.
GeneIDi5538398.
KEGGirca:Rcas_0932.
PATRICi23339991. VBIRosCas91182_1075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU57046.1 .
RefSeqi WP_012119476.1. NC_009767.1.
YP_001431064.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NHU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_0932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU57046 ; ABU57046 ; Rcas_0932 .
GeneIDi 5538398.
KEGGi rca:Rcas_0932.
PATRICi 23339991. VBIRosCas91182_1075.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi VLDPGDW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RCAS383372:GH89-942-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiA7NHU9_ROSCS
AccessioniPrimary (citable) accession number: A7NHU9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi