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A7NHU9

- A7NHU9_ROSCS

UniProt

A7NHU9 - A7NHU9_ROSCS

Protein

NAD kinase

Gene

nadK

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621Proton acceptorUniRule annotation
    Binding sitei67 – 671NADUniRule annotation
    Binding sitei148 – 1481NADUniRule annotation
    Binding sitei165 – 1651NADUniRule annotation
    Binding sitei167 – 1671NADUniRule annotation
    Binding sitei202 – 2021NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 632NADUniRule annotation
    Nucleotide bindingi137 – 1382NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAS383372:GH89-942-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Rcas_0932Imported
    OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)Imported
    Taxonomic identifieri383372 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000000263: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi383372.Rcas_0932.

    Structurei

    3D structure databases

    ProteinModelPortaliA7NHU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiVLDPGDW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7NHU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPIKRVAII FNPYSDESLH MSGEVAGWLT ERSIQVWRGV SHEGRAQHAV    50
    DHTDLVLALG GDGTVLRAAR LAIPSGVPVL PVALGRLNFM AELEPSTLYQ 100
    GLEDMLAGRF WLDSRTLVEA TVLRADGITV SPILALNEII VARGDINRTV 150
    LVDVEIYDAR LTTYHADGVI VASATGSTAY ALAAGGPIID PRSTALVLVP 200
    VAAHLTNVPS LVLHEDAVVT LTLQSRHPAG FSADGHDHIA LHEGDRVIVR 250
    RSQRCCTFAR VYPQSTFYAR MMQRLRRE 278
    Length:278
    Mass (Da):30,268
    Last modified:October 2, 2007 - v1
    Checksum:i2AE8BC4DA153CFE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU57046.1.
    RefSeqiWP_012119476.1. NC_009767.1.
    YP_001431064.1. NC_009767.1.

    Genome annotation databases

    EnsemblBacteriaiABU57046; ABU57046; Rcas_0932.
    GeneIDi5538398.
    KEGGirca:Rcas_0932.
    PATRICi23339991. VBIRosCas91182_1075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU57046.1 .
    RefSeqi WP_012119476.1. NC_009767.1.
    YP_001431064.1. NC_009767.1.

    3D structure databases

    ProteinModelPortali A7NHU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 383372.Rcas_0932.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU57046 ; ABU57046 ; Rcas_0932 .
    GeneIDi 5538398.
    KEGGi rca:Rcas_0932.
    PATRICi 23339991. VBIRosCas91182_1075.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi VLDPGDW.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci RCAS383372:GH89-942-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13941 / HLO8Imported.

    Entry informationi

    Entry nameiA7NHU9_ROSCS
    AccessioniPrimary (citable) accession number: A7NHU9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3