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Protein

NAD kinase

Gene

nadK

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Proton acceptorUniRule annotation1
Binding sitei67NADUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei165NADUniRule annotation1
Binding sitei167NADUniRule annotation1
Binding sitei202NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 63NADUniRule annotation2
Nucleotide bindingi137 – 138NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotationSAAS annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Rcas_0932Imported
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)Imported
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000000263 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_0932.

Structurei

3D structure databases

ProteinModelPortaliA7NHU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiETFFAIN.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NHU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPIKRVAII FNPYSDESLH MSGEVAGWLT ERSIQVWRGV SHEGRAQHAV
60 70 80 90 100
DHTDLVLALG GDGTVLRAAR LAIPSGVPVL PVALGRLNFM AELEPSTLYQ
110 120 130 140 150
GLEDMLAGRF WLDSRTLVEA TVLRADGITV SPILALNEII VARGDINRTV
160 170 180 190 200
LVDVEIYDAR LTTYHADGVI VASATGSTAY ALAAGGPIID PRSTALVLVP
210 220 230 240 250
VAAHLTNVPS LVLHEDAVVT LTLQSRHPAG FSADGHDHIA LHEGDRVIVR
260 270
RSQRCCTFAR VYPQSTFYAR MMQRLRRE
Length:278
Mass (Da):30,268
Last modified:October 2, 2007 - v1
Checksum:i2AE8BC4DA153CFE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA. Translation: ABU57046.1.
RefSeqiWP_012119476.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU57046; ABU57046; Rcas_0932.
KEGGirca:Rcas_0932.
PATRICi23339991. VBIRosCas91182_1075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA. Translation: ABU57046.1.
RefSeqiWP_012119476.1. NC_009767.1.

3D structure databases

ProteinModelPortaliA7NHU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi383372.Rcas_0932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU57046; ABU57046; Rcas_0932.
KEGGirca:Rcas_0932.
PATRICi23339991. VBIRosCas91182_1075.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiETFFAIN.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7NHU9_ROSCS
AccessioniPrimary (citable) accession number: A7NHU9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.