A7NH85 (G6PI_ROSCS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	Rcas_0710

Organism

Roseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP]

Taxonomic identifier

383372 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Roseiflexus

Protein attributes

Sequence length	543 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 543	543	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000206371
Sites
	Active site	384	1	By similarity
	Active site	504	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7NH85 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: A03ABDA05C9AD87C	FASTA	543	60,047
	10 20 30 40 50 60 MTLLTQIPEW RALETHYRAI RDVHLRRLFA EDPGRGERMT AEAAGLFFDY SKNRVTDETL 70 80 90 100 110 120 RLLMALAEAR GLRARIDAMF RGERINITEN RAVLHVALRA PRGAVILVDG VNVVPDVHAV 130 140 150 160 170 180 LDRMAAFAEQ VRSGAWSGFT GKPIRNIVNI GIGGSDLGPV MAYEALRSYS RRNLTLRFVS 190 200 210 220 230 240 NIDGNDFAEA TRDLDPAETL FIVASKTFTT LETMTNARTA RAWLLAALGD DAAVARHFVA 250 260 270 280 290 300 VSTNAAEVAK FGIDTANMFG FWDWVGGRYS MTSAIGLSTM IALGPDHFRD MLAGFHAMDE 310 320 330 340 350 360 HFRTAPFDRN LPVIHGLLTV WYANFFGVET VAILPYDNYL KRFPAYLQQL TMESNGKSVT 370 380 390 400 410 420 LSGEPVTYQT GPIYWGEPGT NGQHSFYQLI HQGTRLVLCD FIGFAETLNP LGAHHDLLMA 430 440 450 460 470 480 NMFAQAEALA FGKTTEEALA EGTPAWLAPH RTFPGNRPSN TFLAERLTPA VLGALVALYE 490 500 510 520 530 540 HSVFTQGAIW DINSFDQWGV ELGKVLAGRI APELMSEVAP SPAHDSSTNA LIRRYRAWRG RAL

References

[1]

"Complete sequence of Roseiflexus castenholzii DSM 13941." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000804 Genomic DNA. Translation: ABU56832.1.
RefSeq	YP_001430850.1. NC_009767.1.
3D structure databases
ProteinModelPortal	A7NH85.
SMR	A7NH85. Positions 1-539.
ModBase	Search...
Protein-protein interaction databases
STRING	A7NH85.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5538175.
GenomeReviews	Gene locus Rcas_0710 in contig CP000804_GR.
KEGG	rca:Rcas_0710.
PATRIC	23339487. VBIRosCas91182_0824.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	NSLPAWT.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	RCAS383372:RCAS_0710-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ROSCS

Accession

Primary (citable) accession number: A7NH85

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program