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A7NGQ9 (FTHS_ROSCS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Rcas_0522
OrganismRoseiflexus castenholzii (strain DSM 13941 / HLO8) [Complete proteome] [HAMAP]
Taxonomic identifier383372 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeRoseiflexus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087654

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7NGQ9 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: A73508D818F8CE14

FASTA56460,188
        10         20         30         40         50         60 
MRSDLDIAQA ARLRPIRAVA ADLGLTDDDI ELYGRSIAKI DLGILQRLTD QPRGRYIVVT 

        70         80         90        100        110        120 
AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP TFGIKGGAAG GGYSQVLPME 

       130        140        150        160        170        180 
QFNLHLTGDI HAIGAAHNLL AAMIDNHLHH GNQCGIDPYA IFWSRVVDIS DRVLRNVVVG 

       190        200        210        220        230        240 
LGKKEDGPMR QTQFDITVAS EVMAILALTT NLHDLRQRLG RIVAAYTRDG APVTAEDLHA 

       250        260        270        280        290        300 
AGAMTVLLKE AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADMIGLH CADYVVTESG 

       310        320        330        340        350        360 
FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YTITAGRPLD PRLAEENPED 

       370        380        390        400        410        420 
VADGAANLAA QVRIARLFGR PVVVAINRFP DDFPSEVEVI RQVARESGAF DVVESFVFAE 

       430        440        450        460        470        480 
GGAGGCDLAR AAIQACEAPG TFTPLYPLDM SLREKIETLA TKVYGATRVE YTPEASRRLA 

       490        500        510        520        530        540 
QFEHQGYGNL PICMAKTHLS ISHDPKLRGA PSGYVFPIRD VRLAAGAGFI YPLAGDIRTM 

       550        560 
PGLPAHPAAE RIDIDAEGRT RGLS 

« Hide

References

[1]"Complete sequence of Roseiflexus castenholzii DSM 13941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Thompson L.S., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Bryant D.A., Hanada S., Tsukatani Y., Richardson P.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13941 / HLO8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000804 Genomic DNA. Translation: ABU56652.1.
RefSeqYP_001430670.1. NC_009767.1.

3D structure databases

ProteinModelPortalA7NGQ9.
SMRA7NGQ9. Positions 4-562.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING383372.Rcas_0522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU56652; ABU56652; Rcas_0522.
GeneID5537985.
KEGGrca:Rcas_0522.
PATRIC23339041. VBIRosCas91182_0602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycRCAS383372:GH89-529-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_ROSCS
AccessionPrimary (citable) accession number: A7NGQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways