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A7NGQ9

- FTHS_ROSCS

UniProt

A7NGQ9 - FTHS_ROSCS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAS383372:GH89-529-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Rcas_0522
    OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
    Taxonomic identifieri383372 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000000263: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Formate--tetrahydrofolate ligasePRO_1000087654Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi383372.Rcas_0522.

    Structurei

    3D structure databases

    ProteinModelPortaliA7NGQ9.
    SMRiA7NGQ9. Positions 4-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7NGQ9-1 [UniParc]FASTAAdd to Basket

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    MRSDLDIAQA ARLRPIRAVA ADLGLTDDDI ELYGRSIAKI DLGILQRLTD    50
    QPRGRYIVVT AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP 100
    TFGIKGGAAG GGYSQVLPME QFNLHLTGDI HAIGAAHNLL AAMIDNHLHH 150
    GNQCGIDPYA IFWSRVVDIS DRVLRNVVVG LGKKEDGPMR QTQFDITVAS 200
    EVMAILALTT NLHDLRQRLG RIVAAYTRDG APVTAEDLHA AGAMTVLLKE 250
    AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADMIGLH CADYVVTESG 300
    FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YTITAGRPLD 350
    PRLAEENPED VADGAANLAA QVRIARLFGR PVVVAINRFP DDFPSEVEVI 400
    RQVARESGAF DVVESFVFAE GGAGGCDLAR AAIQACEAPG TFTPLYPLDM 450
    SLREKIETLA TKVYGATRVE YTPEASRRLA QFEHQGYGNL PICMAKTHLS 500
    ISHDPKLRGA PSGYVFPIRD VRLAAGAGFI YPLAGDIRTM PGLPAHPAAE 550
    RIDIDAEGRT RGLS 564
    Length:564
    Mass (Da):60,188
    Last modified:October 2, 2007 - v1
    Checksum:iA73508D818F8CE14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU56652.1.
    RefSeqiWP_012119083.1. NC_009767.1.
    YP_001430670.1. NC_009767.1.

    Genome annotation databases

    EnsemblBacteriaiABU56652; ABU56652; Rcas_0522.
    GeneIDi5537985.
    KEGGirca:Rcas_0522.
    PATRICi23339041. VBIRosCas91182_0602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU56652.1 .
    RefSeqi WP_012119083.1. NC_009767.1.
    YP_001430670.1. NC_009767.1.

    3D structure databases

    ProteinModelPortali A7NGQ9.
    SMRi A7NGQ9. Positions 4-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 383372.Rcas_0522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU56652 ; ABU56652 ; Rcas_0522 .
    GeneIDi 5537985.
    KEGGi rca:Rcas_0522.
    PATRICi 23339041. VBIRosCas91182_0602.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RCAS383372:GH89-529-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13941 / HLO8.

    Entry informationi

    Entry nameiFTHS_ROSCS
    AccessioniPrimary (citable) accession number: A7NGQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3