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A7NGQ9

- FTHS_ROSCS

UniProt

A7NGQ9 - FTHS_ROSCS

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Rcas_0522
Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:GH89-529-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Rcas_0522
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000087654Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_0522.

Structurei

3D structure databases

ProteinModelPortaliA7NGQ9.
SMRiA7NGQ9. Positions 4-562.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NGQ9-1 [UniParc]FASTAAdd to Basket

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MRSDLDIAQA ARLRPIRAVA ADLGLTDDDI ELYGRSIAKI DLGILQRLTD    50
QPRGRYIVVT AITPTPLGEG KTTTTIGLGQ ALARLGKRSV VTIRQPSMGP 100
TFGIKGGAAG GGYSQVLPME QFNLHLTGDI HAIGAAHNLL AAMIDNHLHH 150
GNQCGIDPYA IFWSRVVDIS DRVLRNVVVG LGKKEDGPMR QTQFDITVAS 200
EVMAILALTT NLHDLRQRLG RIVAAYTRDG APVTAEDLHA AGAMTVLLKE 250
AIKPNLLQTL EGSPALVHCG PFANIAHGAS SVLADMIGLH CADYVVTESG 300
FGADIGFEKF CDIKCRASGL APDAVVLVAT VRALKAHSGR YTITAGRPLD 350
PRLAEENPED VADGAANLAA QVRIARLFGR PVVVAINRFP DDFPSEVEVI 400
RQVARESGAF DVVESFVFAE GGAGGCDLAR AAIQACEAPG TFTPLYPLDM 450
SLREKIETLA TKVYGATRVE YTPEASRRLA QFEHQGYGNL PICMAKTHLS 500
ISHDPKLRGA PSGYVFPIRD VRLAAGAGFI YPLAGDIRTM PGLPAHPAAE 550
RIDIDAEGRT RGLS 564
Length:564
Mass (Da):60,188
Last modified:October 2, 2007 - v1
Checksum:iA73508D818F8CE14
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU56652.1.
RefSeqiWP_012119083.1. NC_009767.1.
YP_001430670.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU56652; ABU56652; Rcas_0522.
GeneIDi5537985.
KEGGirca:Rcas_0522.
PATRICi23339041. VBIRosCas91182_0602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU56652.1 .
RefSeqi WP_012119083.1. NC_009767.1.
YP_001430670.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NGQ9.
SMRi A7NGQ9. Positions 4-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_0522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU56652 ; ABU56652 ; Rcas_0522 .
GeneIDi 5537985.
KEGGi rca:Rcas_0522.
PATRICi 23339041. VBIRosCas91182_0602.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RCAS383372:GH89-529-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiFTHS_ROSCS
AccessioniPrimary (citable) accession number: A7NGQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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