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Protein

Pantothenate synthetase

Gene

panC

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton donorUniRule annotation1
Binding sitei58Beta-alanineUniRule annotation1
Binding sitei58PantoateUniRule annotation1
Binding sitei150PantoateUniRule annotation1
Binding sitei173ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34ATPUniRule annotation8
Nucleotide bindingi144 – 147ATPUniRule annotation4
Nucleotide bindingi181 – 184ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:G1G9S-357-MONOMER
UniPathwayiUPA00028; UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Rcas_0333
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
Proteomesi
  • UP000000263 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000768621 – 278Pantothenate synthetaseAdd BLAST278

Proteomic databases

PRIDEiA7NG78

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi383372.Rcas_0333

Structurei

3D structure databases

ProteinModelPortaliA7NG78
SMRiA7NG78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQT Bacteria
COG0414 LUCA
HOGENOMiHOG000175516
KOiK01918
OMAiLFNMVQP
OrthoDBiPOG091H00FM

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
TIGR00018 panC, 1 hit

Sequencei

Sequence statusi: Complete.

A7NG78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVIATIGEF RAARAAMHGA VGLVPTMGYL HEGHLSLVRR ARAENDHVIV
60 70 80 90 100
TIFVNPTQFG PSEDLSRYPR DLPRDLALLE AEKIDVVFAP NVAEMYPPGF
110 120 130 140 150
GTFVDVGPIA APLEGAARPG HFRGVATVVC KLFNITTPHR AYFGQKDAQQ
160 170 180 190 200
TLVIRRMTLD LNLPVEIIVC PIVREPDGLA MSSRNVYLNP KERRAATVLF
210 220 230 240 250
RALQAVQERF RAGERNGDAL RAAMRAVIDA EPLAHPDYVS IADLDDLHEL
260 270
DRVTSRALAS LAVRIGTTRL IDNCILEA
Length:278
Mass (Da):30,590
Last modified:October 2, 2007 - v1
Checksum:i5B1BCD6AF24ED4AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000804 Genomic DNA Translation: ABU56465.1
RefSeqiWP_011997869.1, NC_009767.1

Genome annotation databases

EnsemblBacteriaiABU56465; ABU56465; Rcas_0333
KEGGirca:Rcas_0333

Similar proteinsi

Entry informationi

Entry nameiPANC_ROSCS
AccessioniPrimary (citable) accession number: A7NG78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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