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A7NFJ2

- SYL_ROSCS

UniProt

A7NFJ2 - SYL_ROSCS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei666 – 6661ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAS383372:GH89-79-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rcas_0077
    OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
    Taxonomic identifieri383372 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
    ProteomesiUP000000263: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 904904Leucine--tRNA ligasePRO_0000334806Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi383372.Rcas_0077.

    Structurei

    3D structure databases

    ProteinModelPortaliA7NFJ2.
    SMRiA7NFJ2. Positions 11-840.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 5911"HIGH" regionAdd
    BLAST
    Motifi663 – 6675"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7NFJ2-1 [UniParc]FASTAAdd to Basket

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    MSDTGTKRRI ERFDPAIEPK WREFWEREGI FKAGRRAGAP RRYILEMFPY    50
    PSGDLHIGHL KNYVIGDALT RYYVIRGYDV LHPFGWDAFG LPAENAAIKY 100
    GRHPREWTYG NIAESKKSLE IAGIMYDWSR EVTTCDPDYY RWNQWLFLLL 150
    YRKGLAYRAK ATVNWDPVDQ TVLANEQVDA EGRSWRSGAK VEKRELEQWF 200
    FRITAYAERL LNDLDKLDKW PENVKTMQRN WIGRSEGAEV TFLALPPGAD 250
    LHAPPPPDAE PLVVFTTRPD TLWGATFMVL APEHPLVSKL TAPERRAEVE 300
    AYIARARMES EIERTSATRE KTGVFLGSYA INPVNDERIP IWIADYVLMG 350
    YGAGAIMAVP AHDERDFAFA RQFGLPVRVV VQPPGETLDG ATMTEAWPGD 400
    GVMVNSGPIN GLPVGKGEGQ SVKATIAWLE ANGKGKGTVT YRLRDWLISR 450
    QRYWGTPIPM LHLPDGTIKP VPEDQLPVVL PEVQDYLPKG KSPLAAAESW 500
    VNTIDPETGQ PARRDTDTMD TFVDSSWYFL RFCDARNDRE IFSREAAHRW 550
    MPVDQYIGGV EHAILHLLYA RFITKVLYDE GLVPDDEPFR ALFTQGMVQR 600
    RVRTPLEVVA PGMVRFPEEL RRKLELPADA QSLDQARALL KERGYTLEEE 650
    SNGGFTAVSG PVTMSKSAGN GIPVGPFVRQ YGSDVARIVV LFAAPPENSM 700
    EWTDEGVAGA QRFLNRIVAL FSPDREEIVA ALNSGNGAAP EGEERALYRK 750
    LHETIRKVTL DTEQFRFNTA IAALMELLNE ASRYRSEAGR VTPVFAQTAA 800
    TFARLLSPFA PHLAEELHSW CGGTGSVYDT GWPEWDEAAL ALDEVEIVLQ 850
    VNGKLRGRIM APANADEQQL REWALTNPRV LSFVGDKTVR KVVVVPGKLV 900
    NVVV 904
    Length:904
    Mass (Da):101,643
    Last modified:October 2, 2007 - v1
    Checksum:i9B368CC849759718
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU56214.1.
    RefSeqiYP_001430232.1. NC_009767.1.

    Genome annotation databases

    EnsemblBacteriaiABU56214; ABU56214; Rcas_0077.
    GeneIDi5537536.
    KEGGirca:Rcas_0077.
    PATRICi23338024. VBIRosCas91182_0098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000804 Genomic DNA. Translation: ABU56214.1 .
    RefSeqi YP_001430232.1. NC_009767.1.

    3D structure databases

    ProteinModelPortali A7NFJ2.
    SMRi A7NFJ2. Positions 11-840.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 383372.Rcas_0077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU56214 ; ABU56214 ; Rcas_0077 .
    GeneIDi 5537536.
    KEGGi rca:Rcas_0077.
    PATRICi 23338024. VBIRosCas91182_0098.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RCAS383372:GH89-79-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13941 / HLO8.

    Entry informationi

    Entry nameiSYL_ROSCS
    AccessioniPrimary (citable) accession number: A7NFJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3