Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7NFJ2

- SYL_ROSCS

UniProt

A7NFJ2 - SYL_ROSCS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei666 – 6661ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAS383372:GH89-79-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Rcas_0077
OrganismiRoseiflexus castenholzii (strain DSM 13941 / HLO8)
Taxonomic identifieri383372 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesRoseiflexineaeRoseiflexaceaeRoseiflexus
ProteomesiUP000000263: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 904904Leucine--tRNA ligasePRO_0000334806Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi383372.Rcas_0077.

Structurei

3D structure databases

ProteinModelPortaliA7NFJ2.
SMRiA7NFJ2. Positions 11-840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 5911"HIGH" regionAdd
BLAST
Motifi663 – 6675"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NFJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTGTKRRI ERFDPAIEPK WREFWEREGI FKAGRRAGAP RRYILEMFPY
60 70 80 90 100
PSGDLHIGHL KNYVIGDALT RYYVIRGYDV LHPFGWDAFG LPAENAAIKY
110 120 130 140 150
GRHPREWTYG NIAESKKSLE IAGIMYDWSR EVTTCDPDYY RWNQWLFLLL
160 170 180 190 200
YRKGLAYRAK ATVNWDPVDQ TVLANEQVDA EGRSWRSGAK VEKRELEQWF
210 220 230 240 250
FRITAYAERL LNDLDKLDKW PENVKTMQRN WIGRSEGAEV TFLALPPGAD
260 270 280 290 300
LHAPPPPDAE PLVVFTTRPD TLWGATFMVL APEHPLVSKL TAPERRAEVE
310 320 330 340 350
AYIARARMES EIERTSATRE KTGVFLGSYA INPVNDERIP IWIADYVLMG
360 370 380 390 400
YGAGAIMAVP AHDERDFAFA RQFGLPVRVV VQPPGETLDG ATMTEAWPGD
410 420 430 440 450
GVMVNSGPIN GLPVGKGEGQ SVKATIAWLE ANGKGKGTVT YRLRDWLISR
460 470 480 490 500
QRYWGTPIPM LHLPDGTIKP VPEDQLPVVL PEVQDYLPKG KSPLAAAESW
510 520 530 540 550
VNTIDPETGQ PARRDTDTMD TFVDSSWYFL RFCDARNDRE IFSREAAHRW
560 570 580 590 600
MPVDQYIGGV EHAILHLLYA RFITKVLYDE GLVPDDEPFR ALFTQGMVQR
610 620 630 640 650
RVRTPLEVVA PGMVRFPEEL RRKLELPADA QSLDQARALL KERGYTLEEE
660 670 680 690 700
SNGGFTAVSG PVTMSKSAGN GIPVGPFVRQ YGSDVARIVV LFAAPPENSM
710 720 730 740 750
EWTDEGVAGA QRFLNRIVAL FSPDREEIVA ALNSGNGAAP EGEERALYRK
760 770 780 790 800
LHETIRKVTL DTEQFRFNTA IAALMELLNE ASRYRSEAGR VTPVFAQTAA
810 820 830 840 850
TFARLLSPFA PHLAEELHSW CGGTGSVYDT GWPEWDEAAL ALDEVEIVLQ
860 870 880 890 900
VNGKLRGRIM APANADEQQL REWALTNPRV LSFVGDKTVR KVVVVPGKLV

NVVV
Length:904
Mass (Da):101,643
Last modified:October 2, 2007 - v1
Checksum:i9B368CC849759718
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU56214.1.
RefSeqiWP_011997619.1. NC_009767.1.
YP_001430232.1. NC_009767.1.

Genome annotation databases

EnsemblBacteriaiABU56214; ABU56214; Rcas_0077.
GeneIDi5537536.
KEGGirca:Rcas_0077.
PATRICi23338024. VBIRosCas91182_0098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000804 Genomic DNA. Translation: ABU56214.1 .
RefSeqi WP_011997619.1. NC_009767.1.
YP_001430232.1. NC_009767.1.

3D structure databases

ProteinModelPortali A7NFJ2.
SMRi A7NFJ2. Positions 11-840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 383372.Rcas_0077.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU56214 ; ABU56214 ; Rcas_0077 .
GeneIDi 5537536.
KEGGi rca:Rcas_0077.
PATRICi 23338024. VBIRosCas91182_0098.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RCAS383372:GH89-79-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13941 / HLO8.

Entry informationi

Entry nameiSYL_ROSCS
AccessioniPrimary (citable) accession number: A7NFJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3