A7NEF9 (GLMM_FRATF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	FTA_1887

Organism

Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) [Complete proteome] [HAMAP]

Taxonomic identifier

458234 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. holarctica

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP-Rule MF_01554
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP-Rule MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01554
Post-translational modification	Activated by phosphorylation By similarity. HAMAP-Rule MF_01554
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Phosphoglucosamine mutase HAMAP-Rule MF_01554		PRO_1000068907
Sites
	Active site	101	1	Phosphoserine intermediate By similarity
	Metal binding	101	1	Magnesium; via phosphate group By similarity
	Metal binding	239	1	Magnesium By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
Amino acid modifications
	Modified residue	101	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7NEF9 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: C514FE4031672862	FASTA	443	48,207
	10 20 30 40 50 60 MAKYFGTDGI RGEVANSTIT VEFTQKLGNA VGSLINQKNY PKFVIVGQDT RSSGGFLKFA 70 80 90 100 110 120 LVSGLNAAGI DVLDLGVVPT PVVAFMTVKH RAAAGFVITA SHNKFTDNGI KLFSSNGFKL 130 140 150 160 170 180 DDALEEEVED MIDGDFIYQP QFKFGSYKIL ANAIDEYIES IHSRFAKFVN YKGKVVVDCA 190 200 210 220 230 240 HGAASHNFEA LLDKFGINYV SIASNPDGLN INVGCGATCV SNIKKAVKEQ KADLGISLDG 250 260 270 280 290 300 DADRIIIVDE NGQEIDGDGI LNILAQYSDI CGGTNGIVGT QMTNMSYENH YRANKIPFIR 310 320 330 340 350 360 SKVGDRYVLE DLVKYGYKIG GESSGHVINL NFGTTGDGLF TAIQLLAIFS QAYKPVSEFK 370 380 390 400 410 420 LQGELMQQTL INVPLTKKVA REDLQKVASD VNDVEKRLGN RGRVLLRPSG TEPVLRVMVE 430 440 ADDKSLATNE AEYLVEKVKQ KLV

References

[1]

"Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00." Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W., Lion C., Dempsey M.P. PLoS ONE 4:E7041-E7041(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FTNF002-00 / FTA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000803 Genomic DNA. Translation: ABU62362.1.
RefSeq	YP_001429318.1. NC_009749.1.
3D structure databases
ProteinModelPortal	A7NEF9.
ModBase	Search...
Protein-protein interaction databases
STRING	119857.FTL_1781.
Proteomic databases
PRIDE	A7NEF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU62362; ABU62362; FTA_1887.
GeneID	5524353.
KEGG	fta:FTA_1887.
PATRIC	17949244. VBIFraTul129798_1963.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HOG000268678.
KO	K03431.
OMA	TLMSNMS.
ProtClustDB	PRK14320.
Enzyme and pathway databases
BioCyc	FTUL458234:GH31-1717-MONOMER.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
HAMAP	MF_01554_B. GlmM_B.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. glmM. 1 hit.
PROSITE	PS00710. PGM_PMM. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_FRATF

Accession

Primary (citable) accession number: A7NEF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 2, 2007
Last modified:	May 29, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program