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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 110ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:FTA_1702
OrganismiFrancisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Taxonomic identifieri458234 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000568831 – 416UDP-N-acetylmuramoylalanine--D-glutamate ligaseAdd BLAST416

Proteomic databases

PRIDEiA7NDX4

Structurei

3D structure databases

ProteinModelPortaliA7NDX4
SMRiA7NDX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000049427
KOiK01925
OMAiLWVDDSK

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00639 MurD, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR005762 UDP-N-AcMur-Glu_ligase
PfamiView protein in Pfam
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01087 murD, 1 hit

Sequencei

Sequence statusi: Complete.

A7NDX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFYFNDNK ITKLLMVGYG STGKSVCDFL ANFIDITVDI SQNDDEFVNY
60 70 80 90 100
DLNSYDLITV SPGIPLNKSP YRALTKFKDK IVSDIDIFYQ YIKDTKAKTI
110 120 130 140 150
AVTGSNGKST VVTMTDFVLK DLGYKSILVG NIGTPALNKI GEKFDYCVVE
160 170 180 190 200
VSSFQINLFN CVRFDLGCII NVSPDHLDRY QNFEQYKQSK LNLAKFSNDF
210 220 230 240 250
FVYDVHNGIK YAGEYQIIRG AIYRNSTKLL DIVETKLFGE HNLENIIVVL
260 270 280 290 300
NILDRLGLDI NQAIDSIKKF KGLEHRCKIV KKVNGTTYIN DSKGTNVGAT
310 320 330 340 350
IAALNSITNS KNIILLLGGV AKGGDFSLMI KSLDKYVKYV YIYGADKEYI
360 370 380 390 400
ESYIKGYCKY QLCNNMKQAF ELASQKANSN EIVLLSPACA SFDEFSGYAQ
410
RGEVFQNLVA QLEQKS
Length:416
Mass (Da):46,779
Last modified:October 2, 2007 - v1
Checksum:iC99E35540681C1FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA Translation: ABU62177.1
RefSeqiWP_003017010.1, NC_009749.1

Genome annotation databases

EnsemblBacteriaiABU62177; ABU62177; FTA_1702
KEGGifta:FTA_1702

Entry informationi

Entry nameiMURD_FRATF
AccessioniPrimary (citable) accession number: A7NDX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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