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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:FTA_1684
OrganismiFrancisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Taxonomic identifieri458234 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000180301 – 581Arginine--tRNA ligaseAdd BLAST581

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7NDV6.
SMRiA7NDV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 132"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247212.
KOiK01887.
OMAiNKPLHLG.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A7NDV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIENYLSET LAKVFQKLGY AESFAKVVTS TREDVGHFQC NGAMPLAKFA
60 70 80 90 100
KKPPLAIAEE IVEHIDAEDI FAKLEVAKPG FINITLAPKF LADTTNRFLN
110 120 130 140 150
SNKFGVQNNL PNRKVVLDFG GPNVAKPMHV GHIRSALLGD ALQRIHRFCG
160 170 180 190 200
DTVISDVHLG DWGTQMGMLI EEIKLQSPQL VYFDENYTGE YPTESPITVQ
210 220 230 240 250
ELAEIYPRAS KRCKSDINEM EKARLATFEL QQGRRGYVAL WQHFVRISID
260 270 280 290 300
AVKKDFDSLD VHFDLWLGES DANKFIDEMI SYFQANNFIY EDEGAWVIDT
310 320 330 340 350
NKDGVPPLIV IKKDGGVMYG TTDLATLWQR SKDLDPDEII YVVDKRQSLH
360 370 380 390 400
FKQVFSVAER TKVVSEKCKL KHVAFGTVNG KDGRPFKTRE GGVMHLADLI
410 420 430 440 450
SQAKEYAKNR MPDENDDSII DQIAMATIKF GDLINNYAND YFFDLEKFAQ
460 470 480 490 500
HEGKTGPYLL YTVVRAKSIL RKIFGDNYDI KSLAKDYKVV NAHNEYEEKL
510 520 530 540 550
QLQLIQFPIA VQRAYENSQP HHICEYAYSL ANSFNKFYVN CPINNLDDES
560 570 580
LKKARIALCM ATVKAMTIAS DLIGISIPER M
Length:581
Mass (Da):65,925
Last modified:October 2, 2007 - v1
Checksum:iA18F889F0A1FEC41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA. Translation: ABU62159.1.
RefSeqiWP_010031328.1. NC_009749.1.

Genome annotation databases

EnsemblBacteriaiABU62159; ABU62159; FTA_1684.
KEGGifta:FTA_1684.

Similar proteinsi

Entry informationi

Entry nameiSYR_FRATF
AccessioniPrimary (citable) accession number: A7NDV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families