A7NDM9 (TDH_FRATF) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: L-threonine 3-dehydrogenase EC=1.1.1.103 | ||||
| Gene names |
| ||||
| Organism | Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 458234 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › ![]() |
Protein attributes
| Sequence length | 351 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP-Rule MF_00627 |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Pathway | Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP-Rule MF_00627 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | L-threonine catabolic process to glycine Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 351 | 351 | L-threonine 3-dehydrogenase HAMAP-Rule MF_00627 | PRO_1000051637 | |||||
Sites | |||||||||
| Metal binding | 39 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 64 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 94 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 97 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 100 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 108 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 149 | 1 | Zinc 1; catalytic By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00." Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W., Lion C., Dempsey M.P. PLoS ONE 4:E7041-E7041(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FTNF002-00 / FTA. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000803 Genomic DNA. Translation: ABU62082.1. |
| RefSeq | YP_001429038.1. NC_009749.1. |
3D structure databases | |
| ProteinModelPortal | A7NDM9. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 119857.FTL_1523. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | ABU62082; ABU62082; FTA_1607. |
| GeneID | 5523342. |
| KEGG | fta:FTA_1607. |
| PATRIC | 17948646. VBIFraTul129798_1674. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1063. |
| HOGENOM | HOG000294686. |
| KO | K00060. |
| OMA | MSIDWNK. |
| ProtClustDB | PRK05396. |
Enzyme and pathway databases | |
| BioCyc | FTUL458234:GH31-1426-MONOMER. |
| UniPathway | UPA00046; UER00505. |
Family and domain databases | |
| Gene3D | 3.40.50.720. 1 hit. |
| HAMAP | MF_00627. Thr_dehydrog. |
| InterPro | IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR004627. L-Threonine_3-DHase. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| PANTHER | PTHR11695. PTHR11695. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| SUPFAM | SSF50129. GroES_like. 1 hit. |
| TIGRFAMs | TIGR00692. tdh. 1 hit. |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TDH_FRATF | ||||||||
| Accession | Primary (citable) accession number: A7NDM9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
