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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciFTUL458234:GH31-1244-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:FTA_1358
OrganismiFrancisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Taxonomic identifieri458234 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Methionyl-tRNA formyltransferasePRO_1000020064Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA7NCY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1164Tetrahydrofolate (THF) bindingUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177.
KOiK00604.
OMAiSCEIDSC.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NCY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLNIIFAG TPDISAQVLK DLYKSQHNIQ AVLTQPDRAK GRGKKVQFSP
60 70 80 90 100
VKEVALANHT PVFQPLSFKK NPEVLEQIKQ LKPDVIVVIA YGIIVPQEFL
110 120 130 140 150
DIPRYGCLNI HVSLLPKWRG AAPIQRAIQA GDTKTGVCIM QMDAGLDTGD
160 170 180 190 200
ILNTLEIEIQ ETDTSQTLHD KFAKLSIKPL LETLEKIEII KPEPQQGEPT
210 220 230 240 250
YAHKITKQEG LIDFTKSAWR ISCHIRAFTP WPGAYFILDD EAIKVGEFEI
260 270 280 290 300
LYQNTDNRKA GTIIDIYRSG FDIATSDKII RFRQLQFPNK KMLNIVDILN
310
GKDLDKYIGY KLG
Length:313
Mass (Da):35,353
Last modified:October 2, 2007 - v1
Checksum:iF59D5D71EE1348A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA. Translation: ABU61833.1.
RefSeqiWP_003016443.1. NC_009749.1.

Genome annotation databases

EnsemblBacteriaiABU61833; ABU61833; FTA_1358.
KEGGifta:FTA_1358.
PATRICi17948120. VBIFraTul129798_1419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA. Translation: ABU61833.1.
RefSeqiWP_003016443.1. NC_009749.1.

3D structure databases

ProteinModelPortaliA7NCY0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU61833; ABU61833; FTA_1358.
KEGGifta:FTA_1358.
PATRICi17948120. VBIFraTul129798_1419.

Phylogenomic databases

HOGENOMiHOG000261177.
KOiK00604.
OMAiSCEIDSC.
OrthoDBiEOG6B09WV.

Enzyme and pathway databases

BioCyciFTUL458234:GH31-1244-MONOMER.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
[Graphical view]
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FTNF002-00 / FTA.

Entry informationi

Entry nameiFMT_FRATF
AccessioniPrimary (citable) accession number: A7NCY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 11, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.