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A7NBV3

- RUVC_FRATF

UniProt

A7NBV3 - RUVC_FRATF

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Protein
Crossover junction endodeoxyribonuclease RuvC
Gene
ruvC, FTA_0980
Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Metal bindingi66 – 661Magnesium By similarity
Metal bindingi138 – 1381Magnesium By similarity
Metal bindingi141 – 1411Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciFTUL458234:GH31-908-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:FTA_0980
OrganismiFrancisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Taxonomic identifieri458234 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000261: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Crossover junction endodeoxyribonuclease RuvCUniRule annotation
PRO_1000002755Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi119857.FTL_0930.

Structurei

3D structure databases

ProteinModelPortaliA7NBV3.
SMRiA7NBV3. Positions 2-156.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OMAiMQIKLAL.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NBV3-1 [UniParc]FASTAAdd to Basket

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MVILGIDPGS RITGFGVIKV QDNKIYYVAS GCIQITEITT PKRLKQIADG    50
ITQIINIYAP TEAAIEQIFM FQNPMGAIKL GQARGVAMCT LAINNLEVSE 100
YSAKQIKQAV VGTGGAAKSQ VQHMVQSLLG LSKKPPEDAA DALAIAICHY 150
HSSKSLAKIS GASRVSQKRI K 171
Length:171
Mass (Da):18,269
Last modified:October 2, 2007 - v1
Checksum:i0D694AD33BC22DAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000803 Genomic DNA. Translation: ABU61456.1.
RefSeqiWP_003015702.1. NC_009749.1.
YP_001428412.1. NC_009749.1.

Genome annotation databases

EnsemblBacteriaiABU61456; ABU61456; FTA_0980.
GeneIDi5523556.
KEGGifta:FTA_0980.
PATRICi17947318. VBIFraTul129798_1025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000803 Genomic DNA. Translation: ABU61456.1 .
RefSeqi WP_003015702.1. NC_009749.1.
YP_001428412.1. NC_009749.1.

3D structure databases

ProteinModelPortali A7NBV3.
SMRi A7NBV3. Positions 2-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 119857.FTL_0930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU61456 ; ABU61456 ; FTA_0980 .
GeneIDi 5523556.
KEGGi fta:FTA_0980.
PATRICi 17947318. VBIFraTul129798_1025.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OMAi MQIKLAL.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci FTUL458234:GH31-908-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FTNF002-00 / FTA.

Entry informationi

Entry nameiRUVC_FRATF
AccessioniPrimary (citable) accession number: A7NBV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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