A7NB16 (GLO2_FRATF)
Reviewed,
UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 23.
History...
Names and origin
| Protein names | Recommended name: Hydroxyacylglutathione hydrolase EC=3.1.2.6 Alternative name(s): Glyoxalase II Short name=Glx II | ||||
| Gene names |
| ||||
| Organism | Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 458234 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella |
Protein attributes
| Sequence length | 252 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374 |
| Catalytic activity | S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374 |
| Cofactor | Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374 |
| Pathway | Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374 |
| Subunit structure | Monomer By similarity. HAMAP MF_01374 |
| Sequence similarities | Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | hydroxyacylglutathione hydrolase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 252 | 252 | Hydroxyacylglutathione hydrolase HAMAP MF_01374 | PRO_1000068217 | |||||
Sites | |||||||||
| Metal binding | 54 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 56 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 58 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 59 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 111 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 130 | 1 | Zinc 1 By similarity | ||||||
| Metal binding | 130 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 170 | 1 | Zinc 2 By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00." Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W., Lion C., Dempsey M.P. PLoS ONE 4:E7041-E7041(2009) [PubMed: 19756146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000803 Genomic DNA. Translation: ABU61169.1. |
| RefSeq | YP_001428125.1. |
3D structure databases | |
| ProteinModelPortal | A7NB16. |
| SMR | A7NB16. Positions 13-252. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A7NB16. |
Genome annotation databases | |
| GeneID | 5523650. |
| GenomeReviews | Gene locus FTA_0693 in contig CP000803_GR. |
| KEGG | fta:FTA_0693. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0491. |
| HOGENOM | HBG753931. |
| OMA | HPPVYVA. |
| ProtClustDB | CLSK935013. |
Enzyme and pathway databases | |
| BioCyc | FTUL458234:FTA_0693-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01374. Glyoxalase_2. [Tree] |
| InterPro | IPR001279. Blactmase-like. IPR017782. Hydroxyacylglutathione_Hdrlase. [Graphical view] |
| Pfam | PF00753. Lactamase_B. 1 hit. [Graphical view] |
| SMART | SM00849. Lactamase_B. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GLO2_FRATF | ||||||||
| Accession | Primary (citable) accession number: A7NB16 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


