A7NA00 (A7NA00_FRATF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase HAMAP-Rule MF_00376
EC=2.7.1.24 HAMAP-Rule MF_00376

Alternative name(s):
Dephospho-CoA kinase
Dephosphocoenzyme A kinase HAMAP-Rule MF_00376

Gene names

Name:	coaE HAMAP-Rule MF_00376 EMBL ABU60803.1
Ordered Locus Names:	FTA_0326

Organism

Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) [Complete proteome] [HAMAP]

Taxonomic identifier

458234 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella › Francisella tularensis › Francisella tularensis subsp. holarctica

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00376.
Sequence similarities	Belongs to the CoaE family. HAMAP-Rule MF_00376 Contains 1 DPCK (dephospho-CoA kinase) domain. HAMAP-Rule MF_00376 SAAS SAAS001977

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis HAMAP-Rule MF_00376
Cellular component	Cytoplasm HAMAP-Rule MF_00376
Ligand	ATP-binding HAMAP-Rule MF_00376 SAAS SAAS001977 Nucleotide-binding
Molecular function	Kinase HAMAP-Rule MF_00376 EMBL ABU60803.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	13 – 20	8	ATP By similarity HAMAP-Rule MF_00376

Sequences

	Sequence		Length	Mass (Da)
	A7NA00 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 44556AEF2806D7C1	FASTA	204	23,434
	10 20 30 40 50 60 MNFINTYPIG ITGGIASGKS TATRILKEKL NLNVVCADTI SREITKKPSV IKKIAEKFGD 70 80 90 100 110 120 EIVMNKQINR AMLRAIITES KEAKKWLEDY LHPVINKEIK KQVKESDTVM TIVDIPLLGP 130 140 150 160 170 180 YNFRHYDYLK KVIVIKADLE TRIRRLMERD GKNRQQAVAF INLQISDKER EKIADFVIDN 190 200 TELTDQELES KLITTINEIT NLTN

References

[1]

"Complete genome sequence of Francisella tularensis subspecies holarctica FTNF002-00." Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D., Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H., Zhou L.W., Lion C., Dempsey M.P. PLoS ONE 4:E7041-E7041(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FTNF002-00 / FTA.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000803 Genomic DNA. Translation: ABU60803.1.
RefSeq	YP_001427759.1. NC_009749.1.
3D structure databases
ProteinModelPortal	A7NA00.
ModBase	Search...
Protein-protein interaction databases
STRING	458234.FTA_0326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU60803; ABU60803; FTA_0326.
GeneID	5522977.
KEGG	fta:FTA_0326.
PATRIC	17945914. VBIFraTul129798_0343.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0237.
HOGENOM	HOG000020768.
KO	K00859.
OMA	IDAQWAN.
ProtClustDB	PRK14733.
Enzyme and pathway databases
BioCyc	FTUL458234:GH31-306-MONOMER.
UniPathway	UPA00241; UER00356.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase.
InterPro	IPR001977. Depp_CoAkinase. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A7NA00_FRATF

Accession

Primary (citable) accession number: A7NA00

Entry history

Integrated into UniProtKB/TrEMBL:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)