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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. dephospho-CoA kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. coenzyme A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

Coenzyme A biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFTUL458234:GH31-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotationImported
Ordered Locus Names:FTA_0326Imported
OrganismiFrancisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)Imported
Taxonomic identifieri458234 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000000261: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi458234.FTA_0326.

Structurei

3D structure databases

ProteinModelPortaliA7NA00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation
Contains 1 DPCK (dephospho-CoA kinase) domain.UniRule annotation
Contains DPCK (dephospho-CoA kinase) domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020768.
KOiK00859.
OMAiNANELKW.
OrthoDBiEOG6HTP3H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7NA00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFINTYPIG ITGGIASGKS TATRILKEKL NLNVVCADTI SREITKKPSV
60 70 80 90 100
IKKIAEKFGD EIVMNKQINR AMLRAIITES KEAKKWLEDY LHPVINKEIK
110 120 130 140 150
KQVKESDTVM TIVDIPLLGP YNFRHYDYLK KVIVIKADLE TRIRRLMERD
160 170 180 190 200
GKNRQQAVAF INLQISDKER EKIADFVIDN TELTDQELES KLITTINEIT

NLTN
Length:204
Mass (Da):23,434
Last modified:October 2, 2007 - v1
Checksum:i44556AEF2806D7C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA. Translation: ABU60803.1.
RefSeqiYP_001427759.1. NC_009749.1.

Genome annotation databases

EnsemblBacteriaiABU60803; ABU60803; FTA_0326.
GeneIDi5522977.
KEGGifta:FTA_0326.
PATRICi17945914. VBIFraTul129798_0343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000803 Genomic DNA. Translation: ABU60803.1.
RefSeqiYP_001427759.1. NC_009749.1.

3D structure databases

ProteinModelPortaliA7NA00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi458234.FTA_0326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU60803; ABU60803; FTA_0326.
GeneIDi5522977.
KEGGifta:FTA_0326.
PATRICi17945914. VBIFraTul129798_0343.

Phylogenomic databases

eggNOGiCOG0237.
HOGENOMiHOG000020768.
KOiK00859.
OMAiNANELKW.
OrthoDBiEOG6HTP3H.

Enzyme and pathway databases

BioCyciFTUL458234:GH31-306-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FTNF002-00 / FTAImported.

Entry informationi

Entry nameiA7NA00_FRATF
AccessioniPrimary (citable) accession number: A7NA00
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.