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A7N7S2 (THIM_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:VIBHAR_06843
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021539

Sites

Binding site451Substrate; via amide nitrogen By similarity
Binding site1211ATP By similarity
Binding site1671ATP By similarity
Binding site1941Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A7N7S2 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: C6C9DC1D1BF5F44E

FASTA26327,503
        10         20         30         40         50         60 
MLIEQITQAL TAVRQQKPLV VNITNYVVMN NTANALLAIG ASPIMAHSKQ EMVEMMSFAG 

        70         80         90        100        110        120 
ALVINIGTLD SVWTPRMSYA VEQANANGKI VVLDPVGCGA SSLRTETSRE IARLADKLII 

       130        140        150        160        170        180 
RGNASEIIAL AGEQAQSKGV DALDSSDAAL GAANFLVAEY GASVVISGET DYIVTKGQTV 

       190        200        210        220        230        240 
QLNNGHEMMP YVTGMGCTLS ALTGAFAAVG DDTGLAAAAV LGVVGEIAAE QARGPGSLQM 

       250        260 
NLLDELYQLD EETLAKRLKM QVS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000790 Genomic DNA. Translation: ABU74718.1.
RefSeqYP_001448945.1. NC_009784.1.
YP_008528250.1. NC_022270.1.

3D structure databases

ProteinModelPortalA7N7S2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_06843.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU74718; ABU74718; VIBHAR_06843.
GeneID16817799.
5557696.
KEGGvca:M892_18370.
vha:VIBHAR_06843.
PATRIC20137741. VBIVibHar24526_5338.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-5829-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_VIBCB
AccessionPrimary (citable) accession number: A7N7S2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways