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A7N7S2

- THIM_VIBCB

UniProt

A7N7S2 - THIM_VIBCB

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, VIBHAR_06843
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate; via amide nitrogen By similarity
Binding sitei121 – 1211ATP By similarity
Binding sitei167 – 1671ATP By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-5829-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:VIBHAR_06843
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Hydroxyethylthiazole kinaseUniRule annotation
PRO_1000021539Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_06843.

Structurei

3D structure databases

ProteinModelPortaliA7N7S2.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N7S2-1 [UniParc]FASTAAdd to Basket

« Hide

MLIEQITQAL TAVRQQKPLV VNITNYVVMN NTANALLAIG ASPIMAHSKQ    50
EMVEMMSFAG ALVINIGTLD SVWTPRMSYA VEQANANGKI VVLDPVGCGA 100
SSLRTETSRE IARLADKLII RGNASEIIAL AGEQAQSKGV DALDSSDAAL 150
GAANFLVAEY GASVVISGET DYIVTKGQTV QLNNGHEMMP YVTGMGCTLS 200
ALTGAFAAVG DDTGLAAAAV LGVVGEIAAE QARGPGSLQM NLLDELYQLD 250
EETLAKRLKM QVS 263
Length:263
Mass (Da):27,503
Last modified:October 2, 2007 - v1
Checksum:iC6C9DC1D1BF5F44E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74718.1.
RefSeqiYP_001448945.1. NC_009784.1.
YP_008528250.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU74718; ABU74718; VIBHAR_06843.
GeneIDi16817799.
5557696.
KEGGivca:M892_18370.
vha:VIBHAR_06843.
PATRICi20137741. VBIVibHar24526_5338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74718.1 .
RefSeqi YP_001448945.1. NC_009784.1.
YP_008528250.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N7S2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_06843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU74718 ; ABU74718 ; VIBHAR_06843 .
GeneIDi 16817799.
5557696.
KEGGi vca:M892_18370.
vha:VIBHAR_06843.
PATRICi 20137741. VBIVibHar24526_5338.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci VHAR338187:GJCH-5829-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiTHIM_VIBCB
AccessioniPrimary (citable) accession number: A7N7S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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