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Reviewed, UniProtKB/Swiss-Prot A7N6S2 (CQSS_VIBHB)

Last modified January 19, 2010. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    CAI-1 autoinducer sensor kinase/phosphatase cqsS
    EC=2.7.13.3
    EC=3.1.3.-
Alternative name(s):
    Cholerae quorum-sensing sensor
Gene names
Name: cqsS
Ordered Locus Names: VIBHAR_06089
OrganismVibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length681 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Senses the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO. Ref.1

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 histidine kinase domain.

Contains 1 response regulatory domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 681681CAI-1 autoinducer sensor kinase/phosphatase cqsS
PRO_0000316892

Regions

Transmembrane17 – 3721 Potential
Transmembrane73 – 9321 Potential
Transmembrane112 – 13221 Potential
Transmembrane148 – 16821 Potential
Domain187 – 413227Histidine kinase
Domain564 – 681118Response regulatory

Amino acid modifications

Modified residue1901Phosphohistidine; by autocatalysis By similarity
Modified residue61314-aspartylphosphate By similarity

Experimental info

Sequence conflict4841A → R in AAT86007. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
A7N6S2-1 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 66EFACCF3F3DF932

FASTA68177,799
        10         20         30         40         50         60 
MDAIRKVYQY AEPNLSLVGW MGFIGFPIYY IVWEFMFPQP YENLPLRILC SVLFFGIIYR 

        70         80         90        100        110        120 
NRTPFEWRGF LPAYYQVVTT LCLPCFFFYM LLMNNWSNVW VMSFMSAIFL HILLVHITSV 

       130        140        150        160        170        180 
MFVQTFVGIG LATFFAWVAQ GFHLELTMDW THVPIFLFIY LFGNLFYFRN QVEHEAKVSI 

       190        200        210        220        230        240 
AKSFGAGIAH EMRNPLSGLL TSIDVIQSVL PNPKEGKKEQ YTLSDEDVTL LREVSSDAMK 

       250        260        270        280        290        300 
IIHSGNETID LLLTSIDENR VSRSTFKKHS AQSVVESAIE SFSYKRSTDR FAISLDVRSE 

       310        320        330        340        350        360 
FDFLGSDTLL KYVMYNLFKN AFHHRSSEDF HIHVTMYSDE FANQIVVTDN GSGIAPEVLQ 

       370        380        390        400        410        420 
SIFQDFYTTG KSGNYGLGLP FCKKVMRSFG GDIRCQSEVG EWSQFTMTFP TIGSSAVKEI 

       430        440        450        460        470        480 
KSELTKLKTI LFVSEQNILV SKVTDIARFM RFELTVLDVP AVLKNKEYEF EFDLILIDME 

       490        500        510        520        530        540 
SLDASGSHID KVESLLSFTE ARIVYMFEHH PIQRARSVSF EPIWVETQAW LLNTRATIDR 

       550        560        570        580        590        600 
LLYDANYVVP SMPAKPLDST NKRTIMVVDD NESLRKFTAM LLEKQGFEVI QTEDGLQAIN 

       610        620        630        640        650        660 
ALNENNVDLI LMDIEMPVMD GVEASRQIRG SNKAYASVPI IAHTGDSSPI TLDKIGSSGM 

       670        680 
SDFIVKPADK NRLFDKIANW I

« Hide

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References

« Hide 'large scale' references
[1]"Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi."
Henke J.M., Bassler B.L.
J. Bacteriol. 186:6902-6914(2004) [PubMed: 15466044] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS THE CAI-1 SENSOR.
[2]Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY625893 Genomic DNA. Translation: AAT86007.1.
CP000790 Genomic DNA. Translation: ABU73982.1.
RefSeqYP_001448209.1.

3D structure databases

SMRA7N6S2. Positions 181-411, 301-420, 558-681.
ModBaseSearch...

Protein-protein interaction databases

STRINGA7N6S2.

Genome annotation databases

GeneID5556966.
GenomeReviewsGene locus VIBHAR_06089 in contig CP000790_GR.
KEGGvha:VIBHAR_06089.
NMPDRfig|338187.4.peg.3584.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHBG625184.
OMAAIFLHIL.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR011006. CheY-like.
IPR004358. Sig_transdc_His_kin-like_C.
IPR003661. Sig_transdc_His_kin_sub1_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PfamPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
PROSITEPS50109. HIS_KIN. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCQSS_VIBHB
AccessionPrimary (citable) accession number: A7N6S2
Secondary accession number(s): Q693Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: January 19, 2010
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents