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A7N5E9

- FTHS_VIBCB

UniProt

A7N5E9 - FTHS_VIBCB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-4928-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VIBHAR_05943
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_1000068800Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_05943.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7N5E9-1 [UniParc]FASTAAdd to Basket

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    MQSDIEICRN TPLSSIATVA ANAGLLPHEL DTHGKHKAKV HPQCLERLTD    50
    NQDGKLVLVT AITPTPLGEG KTVTTIGLSQ GLSKINQSVM ACIRQPSMGP 100
    VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA SAALDARLYH 150
    EQREGYDAFE ARTSLRALKI DVERITWKRV MDHNDRALRM VKIGLNEEGK 200
    NINGFEREEG FDISAASELM AILALANDLK DLRQRIGRIV VAYDLNGNPV 250
    TTEDLQVAGA MAVTLKETIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADQIALKLSS YVVTEAGFGS DMGFEKACNI KALAADRAPD CVVIVATLRG 350
    LKANSGHYDL RPGMAIPDSI FNPDQAALEA GFENLKWHIN NVHKYGIPAV 400
    VAINQFPQDS GQELAELKAL IERFNPEVKV AVSTVFAQGG EGAIELAQHV 450
    VETCEQGAQF RPLYTKKQSL KEKLMAVCEV GYGASNIEMS ELAKQQLAHF 500
    EKLGFDDLAV CIAKTPLSIT TDSAIKGAPS GFAVPIRELR LCAGAGFVYA 550
    LSGNVMTMPG LPDKPTFMNL DLDDQGNIIG LS 582
    Length:582
    Mass (Da):62,330
    Last modified:October 2, 2007 - v1
    Checksum:i2085192FBAF56CFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU73836.1.
    RefSeqiWP_012129485.1. NC_022270.1.
    YP_001448063.1. NC_009784.1.
    YP_008528975.1. NC_022270.1.

    Genome annotation databases

    EnsemblBacteriaiABU73836; ABU73836; VIBHAR_05943.
    GeneIDi16818538.
    5558605.
    KEGGivca:M892_22095.
    vha:VIBHAR_05943.
    PATRICi20136217. VBIVibHar24526_4588.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU73836.1 .
    RefSeqi WP_012129485.1. NC_022270.1.
    YP_001448063.1. NC_009784.1.
    YP_008528975.1. NC_022270.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_05943.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU73836 ; ABU73836 ; VIBHAR_05943 .
    GeneIDi 16818538.
    5558605.
    KEGGi vca:M892_22095.
    vha:VIBHAR_05943.
    PATRICi 20136217. VBIVibHar24526_4588.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci VHAR338187:GJCH-4928-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiFTHS_VIBCB
    AccessioniPrimary (citable) accession number: A7N5E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3