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A7N5E9

- FTHS_VIBCB

UniProt

A7N5E9 - FTHS_VIBCB

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, VIBHAR_05943
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-4928-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:VIBHAR_05943
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000068800Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_05943.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7N5E9-1 [UniParc]FASTAAdd to Basket

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MQSDIEICRN TPLSSIATVA ANAGLLPHEL DTHGKHKAKV HPQCLERLTD    50
NQDGKLVLVT AITPTPLGEG KTVTTIGLSQ GLSKINQSVM ACIRQPSMGP 100
VFGVKGGAAG GGYSQVAPMD ELNLHLTGDI HAVTAAHNLA SAALDARLYH 150
EQREGYDAFE ARTSLRALKI DVERITWKRV MDHNDRALRM VKIGLNEEGK 200
NINGFEREEG FDISAASELM AILALANDLK DLRQRIGRIV VAYDLNGNPV 250
TTEDLQVAGA MAVTLKETIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
ADQIALKLSS YVVTEAGFGS DMGFEKACNI KALAADRAPD CVVIVATLRG 350
LKANSGHYDL RPGMAIPDSI FNPDQAALEA GFENLKWHIN NVHKYGIPAV 400
VAINQFPQDS GQELAELKAL IERFNPEVKV AVSTVFAQGG EGAIELAQHV 450
VETCEQGAQF RPLYTKKQSL KEKLMAVCEV GYGASNIEMS ELAKQQLAHF 500
EKLGFDDLAV CIAKTPLSIT TDSAIKGAPS GFAVPIRELR LCAGAGFVYA 550
LSGNVMTMPG LPDKPTFMNL DLDDQGNIIG LS 582
Length:582
Mass (Da):62,330
Last modified:October 2, 2007 - v1
Checksum:i2085192FBAF56CFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73836.1.
RefSeqiWP_012129485.1. NC_022270.1.
YP_001448063.1. NC_009784.1.
YP_008528975.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU73836; ABU73836; VIBHAR_05943.
GeneIDi16818538.
5558605.
KEGGivca:M892_22095.
vha:VIBHAR_05943.
PATRICi20136217. VBIVibHar24526_4588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73836.1 .
RefSeqi WP_012129485.1. NC_022270.1.
YP_001448063.1. NC_009784.1.
YP_008528975.1. NC_022270.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_05943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU73836 ; ABU73836 ; VIBHAR_05943 .
GeneIDi 16818538.
5558605.
KEGGi vca:M892_22095.
vha:VIBHAR_05943.
PATRICi 20136217. VBIVibHar24526_4588.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci VHAR338187:GJCH-4928-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiFTHS_VIBCB
AccessioniPrimary (citable) accession number: A7N5E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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