Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A7N5E9 (FTHS_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:VIBHAR_05943
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068800

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A7N5E9 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 2085192FBAF56CFB

FASTA58262,330
        10         20         30         40         50         60 
MQSDIEICRN TPLSSIATVA ANAGLLPHEL DTHGKHKAKV HPQCLERLTD NQDGKLVLVT 

        70         80         90        100        110        120 
AITPTPLGEG KTVTTIGLSQ GLSKINQSVM ACIRQPSMGP VFGVKGGAAG GGYSQVAPMD 

       130        140        150        160        170        180 
ELNLHLTGDI HAVTAAHNLA SAALDARLYH EQREGYDAFE ARTSLRALKI DVERITWKRV 

       190        200        210        220        230        240 
MDHNDRALRM VKIGLNEEGK NINGFEREEG FDISAASELM AILALANDLK DLRQRIGRIV 

       250        260        270        280        290        300 
VAYDLNGNPV TTEDLQVAGA MAVTLKETIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 

       310        320        330        340        350        360 
ADQIALKLSS YVVTEAGFGS DMGFEKACNI KALAADRAPD CVVIVATLRG LKANSGHYDL 

       370        380        390        400        410        420 
RPGMAIPDSI FNPDQAALEA GFENLKWHIN NVHKYGIPAV VAINQFPQDS GQELAELKAL 

       430        440        450        460        470        480 
IERFNPEVKV AVSTVFAQGG EGAIELAQHV VETCEQGAQF RPLYTKKQSL KEKLMAVCEV 

       490        500        510        520        530        540 
GYGASNIEMS ELAKQQLAHF EKLGFDDLAV CIAKTPLSIT TDSAIKGAPS GFAVPIRELR 

       550        560        570        580 
LCAGAGFVYA LSGNVMTMPG LPDKPTFMNL DLDDQGNIIG LS 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000790 Genomic DNA. Translation: ABU73836.1.
RefSeqYP_001448063.1. NC_009784.1.
YP_008528975.1. NC_022270.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_05943.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU73836; ABU73836; VIBHAR_05943.
GeneID16818538.
5558605.
KEGGvha:VIBHAR_05943.
PATRIC20136217. VBIVibHar24526_4588.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-4928-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_VIBCB
AccessionPrimary (citable) accession number: A7N5E9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways