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A7N5C4

- GCSP_VIBCB

UniProt

A7N5C4 - GCSP_VIBCB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-4958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VIBHAR_05973
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000045625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiA7N5C4.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_05973.

Structurei

3D structure databases

ProteinModelPortaliA7N5C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N5C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELLQSLST QNEFVARHNG PNKSDQQKML EAINAVSLDS LIDETVPAQI
60 70 80 90 100
RLEQPMNLAE AKSEADMLAA MRKFADQNQI KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM EIANASLLDE
160 170 180 190 200
ATAAAEAMTL CKRAGKSKSN VFFVADDVHP QTIEVVKTRA KFIGFEVLVG
210 220 230 240 250
ALDSLPEQDV FGALVQYPGT TGEVRDLTDL IAKAQANKTL VTVATDLLAS
260 270 280 290 300
ALLKPAGEMG ADVAIGSAQR FGVPMGYGGP HAAFMATRDK HKRTMPGRVI
310 320 330 340 350
GVSIDTNGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVFH
360 370 380 390 400
GAEGLRTIAR RTHHMTAILA AGLTKGGFEL AHNSFFDTIT INTGAQTEDL
410 420 430 440 450
YAKALAADIN LRKLGTQLGV SFDETTTVAD VEALFAVFGV KEEVAALSTE
460 470 480 490 500
IAGNEFAAIP EALRRTTEYL THPVFNTHHS ETQMMRYLKQ LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNAAAEMIP VTWPEFGSIH PFAPADQAAG YAALAKDLKE
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATASM VSMKVVVVKC DEEGNIDVTD LAAKIKKHKD NLSSIMITYP
660 670 680 690 700
STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTTP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGADG ENFAVSAADM
760 770 780 790 800
GSASILPISW AYIAMMGEAG LTDATKVAIL NANYVMEQLR PHYPVLYRGS
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLDNNPL VNAPHTQFDL
910 920 930 940 950
AKEEWDRPYS RELGCFPSKA TKSWKYWPTV NRVDNVYGDR NLICSCPSID

NYED
Length:954
Mass (Da):104,067
Last modified:October 2, 2007 - v1
Checksum:i9FE7A95E6B842F37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73866.1.
RefSeqiYP_001448093.1. NC_009784.1.
YP_008528947.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU73866; ABU73866; VIBHAR_05973.
GeneIDi16818510.
5558848.
KEGGivca:M892_21955.
vha:VIBHAR_05973.
PATRICi20136271. VBIVibHar24526_4615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73866.1 .
RefSeqi YP_001448093.1. NC_009784.1.
YP_008528947.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N5C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_05973.

Proteomic databases

PRIDEi A7N5C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU73866 ; ABU73866 ; VIBHAR_05973 .
GeneIDi 16818510.
5558848.
KEGGi vca:M892_21955.
vha:VIBHAR_05973.
PATRICi 20136271. VBIVibHar24526_4615.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-4958-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiGCSP_VIBCB
AccessioniPrimary (citable) accession number: A7N5C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3