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A7N5C4

- GCSP_VIBCB

UniProt

A7N5C4 - GCSP_VIBCB

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, VIBHAR_05973
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-4958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VIBHAR_05973
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiA7N5C4.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi338187.VIBHAR_05973.

Structurei

3D structure databases

ProteinModelPortaliA7N5C4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N5C4-1 [UniParc]FASTAAdd to Basket

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MTELLQSLST QNEFVARHNG PNKSDQQKML EAINAVSLDS LIDETVPAQI    50
RLEQPMNLAE AKSEADMLAA MRKFADQNQI KRTFIGQGYY NTFTPNVILR 100
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM EIANASLLDE 150
ATAAAEAMTL CKRAGKSKSN VFFVADDVHP QTIEVVKTRA KFIGFEVLVG 200
ALDSLPEQDV FGALVQYPGT TGEVRDLTDL IAKAQANKTL VTVATDLLAS 250
ALLKPAGEMG ADVAIGSAQR FGVPMGYGGP HAAFMATRDK HKRTMPGRVI 300
GVSIDTNGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVFH 350
GAEGLRTIAR RTHHMTAILA AGLTKGGFEL AHNSFFDTIT INTGAQTEDL 400
YAKALAADIN LRKLGTQLGV SFDETTTVAD VEALFAVFGV KEEVAALSTE 450
IAGNEFAAIP EALRRTTEYL THPVFNTHHS ETQMMRYLKQ LENKDFSLTH 500
GMIPLGSCTM KLNAAAEMIP VTWPEFGSIH PFAPADQAAG YAALAKDLKE 550
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA 600
HGTNPATASM VSMKVVVVKC DEEGNIDVTD LAAKIKKHKD NLSSIMITYP 650
STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTTP GFIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGADG ENFAVSAADM 750
GSASILPISW AYIAMMGEAG LTDATKVAIL NANYVMEQLR PHYPVLYRGS 800
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLDNNPL VNAPHTQFDL 900
AKEEWDRPYS RELGCFPSKA TKSWKYWPTV NRVDNVYGDR NLICSCPSID 950
NYED 954
Length:954
Mass (Da):104,067
Last modified:October 2, 2007 - v1
Checksum:i9FE7A95E6B842F37
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73866.1.
RefSeqiYP_001448093.1. NC_009784.1.
YP_008528947.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU73866; ABU73866; VIBHAR_05973.
GeneIDi16818510.
5558848.
KEGGivca:M892_21955.
vha:VIBHAR_05973.
PATRICi20136271. VBIVibHar24526_4615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU73866.1 .
RefSeqi YP_001448093.1. NC_009784.1.
YP_008528947.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N5C4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_05973.

Proteomic databases

PRIDEi A7N5C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU73866 ; ABU73866 ; VIBHAR_05973 .
GeneIDi 16818510.
5558848.
KEGGi vca:M892_21955.
vha:VIBHAR_05973.
PATRICi 20136271. VBIVibHar24526_4615.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-4958-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiGCSP_VIBCB
AccessioniPrimary (citable) accession number: A7N5C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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