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A7N5C4

- GCSP_VIBCB

UniProt

A7N5C4 - GCSP_VIBCB

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-4958-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:VIBHAR_05973
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000045625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiA7N5C4.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_05973.

    Structurei

    3D structure databases

    ProteinModelPortaliA7N5C4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7N5C4-1 [UniParc]FASTAAdd to Basket

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    MTELLQSLST QNEFVARHNG PNKSDQQKML EAINAVSLDS LIDETVPAQI    50
    RLEQPMNLAE AKSEADMLAA MRKFADQNQI KRTFIGQGYY NTFTPNVILR 100
    NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTGM EIANASLLDE 150
    ATAAAEAMTL CKRAGKSKSN VFFVADDVHP QTIEVVKTRA KFIGFEVLVG 200
    ALDSLPEQDV FGALVQYPGT TGEVRDLTDL IAKAQANKTL VTVATDLLAS 250
    ALLKPAGEMG ADVAIGSAQR FGVPMGYGGP HAAFMATRDK HKRTMPGRVI 300
    GVSIDTNGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVFH 350
    GAEGLRTIAR RTHHMTAILA AGLTKGGFEL AHNSFFDTIT INTGAQTEDL 400
    YAKALAADIN LRKLGTQLGV SFDETTTVAD VEALFAVFGV KEEVAALSTE 450
    IAGNEFAAIP EALRRTTEYL THPVFNTHHS ETQMMRYLKQ LENKDFSLTH 500
    GMIPLGSCTM KLNAAAEMIP VTWPEFGSIH PFAPADQAAG YAALAKDLKE 550
    KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA 600
    HGTNPATASM VSMKVVVVKC DEEGNIDVTD LAAKIKKHKD NLSSIMITYP 650
    STHGVYEEQV KEVCEMVHAA GGQVYLDGAN MNAQVGLTTP GFIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGADG ENFAVSAADM 750
    GSASILPISW AYIAMMGEAG LTDATKVAIL NANYVMEQLR PHYPVLYRGS 800
    NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
    EPTESEDLEE LDRFCDAMIA IREEMTKVKN GEWPLDNNPL VNAPHTQFDL 900
    AKEEWDRPYS RELGCFPSKA TKSWKYWPTV NRVDNVYGDR NLICSCPSID 950
    NYED 954
    Length:954
    Mass (Da):104,067
    Last modified:October 2, 2007 - v1
    Checksum:i9FE7A95E6B842F37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU73866.1.
    RefSeqiYP_001448093.1. NC_009784.1.
    YP_008528947.1. NC_022270.1.

    Genome annotation databases

    EnsemblBacteriaiABU73866; ABU73866; VIBHAR_05973.
    GeneIDi16818510.
    5558848.
    KEGGivca:M892_21955.
    vha:VIBHAR_05973.
    PATRICi20136271. VBIVibHar24526_4615.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU73866.1 .
    RefSeqi YP_001448093.1. NC_009784.1.
    YP_008528947.1. NC_022270.1.

    3D structure databases

    ProteinModelPortali A7N5C4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_05973.

    Proteomic databases

    PRIDEi A7N5C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU73866 ; ABU73866 ; VIBHAR_05973 .
    GeneIDi 16818510.
    5558848.
    KEGGi vca:M892_21955.
    vha:VIBHAR_05973.
    PATRICi 20136271. VBIVibHar24526_4615.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci VHAR338187:GJCH-4958-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiGCSP_VIBCB
    AccessioniPrimary (citable) accession number: A7N5C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3