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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2

Gene

accD2

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ZincUniRule annotation1
Metal bindingi32ZincUniRule annotation1
Metal bindingi48ZincUniRule annotation1
Metal bindingi51ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2UniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit beta 2UniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta 2UniRule annotation
Gene namesi
Name:accD2UniRule annotation
Ordered Locus Names:VIBHAR_06018
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000008152 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003590891 – 289Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2Add BLAST289

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_06018.

Structurei

3D structure databases

ProteinModelPortaliA7N581.
SMRiA7N581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 289CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0777. LUCA.
HOGENOMiHOG000021670.
KOiK01963.
OMAiCAFDFRF.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWLEKLLDK NNIINTRKTS IPEGVWTKCP SCEQVLYRIA LKENLEVCPK
60 70 80 90 100
CNHHMRMTAR DRLDSFLDKE KQSEIACEYE PKDVLNFKDK KRYKERIALA
110 120 130 140 150
QKSTGEKDAL VAMKGELLGL PIVACAFEFS FMAGSMGSVV GAKFVEAVDI
160 170 180 190 200
AIEENRGLVC FSACGGARMQ ESLMALMQMA KTSAALDHLS RVGLPYISVL
210 220 230 240 250
TDQTFGGVSA SIAMMGDINI GEPEARIGFA GRRVIEQTVR EKLPDGFQQS
260 270 280
EFLLEHGALD MIVERSDMRR KIGGLIAKLT NKSIQPEAE
Length:289
Mass (Da):32,100
Last modified:October 2, 2007 - v1
Checksum:i464F23217B57540E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000790 Genomic DNA. Translation: ABU73911.1.
RefSeqiWP_012129542.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU73911; ABU73911; VIBHAR_06018.
GeneIDi5557620.
KEGGivca:M892_21775.
vha:VIBHAR_06018.
PATRICifig|338187.25.peg.4288.

Similar proteinsi

Entry informationi

Entry nameiACCD2_VIBCB
AccessioniPrimary (citable) accession number: A7N581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families