A7N4I5 (PNCB_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	VIBHAR_06575

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group › Vibrio harveyi

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000025017

Sequences

	Sequence		Length	Mass (Da)
	A7N4I5 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: B86A87652B4D6C1C	FASTA	436	49,687
	10 20 30 40 50 60 MTTNLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS ELLPEVKAEV 70 80 90 100 110 120 LKLQDITFST EEIEYIKGVA PYLNPEFVDA LHAFRFNPQR DVSFNIKTMA DGTSQLRITI 130 140 150 160 170 180 NGLWKETILY ETIIMSIVSE VRSRARWAEV PVEQFQSVLE EKVRHLKTEL KRRNITNFKF 190 200 210 220 230 240 ADMSTRRRFS FQAQRSMLKY LSKELPDCLT GTSNYHLAKE LGLTPIGTVA HEWFMGHQAL 250 260 270 280 290 300 VNVRDSQKVA LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSNAYVGV RHDSGCPYTW 310 320 330 340 350 360 GEKMIEHYQS LGIDPMTKTL VFTDGLNFEQ ALAICEHFQD RVQVSFGIGT SLANDMGDYA 370 380 390 400 410 420 NAQGIAYKPL SIVIKMVSCN GSPVAKISDE PEKAMCEDIF FLMNLKRRFE QPLDLDECRG 430 LIDRLEDEGD NYLIDA

References

[1]

The Vibrio harveyi Genome Sequencing Project Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000790 Genomic DNA. Translation: ABU74466.1.
RefSeq	YP_001448693.1. NC_009784.1.
3D structure databases
ProteinModelPortal	A7N4I5.
ModBase	Search...
Protein-protein interaction databases
STRING	338187.VIBHAR_06575.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU74466; ABU74466; VIBHAR_06575.
GeneID	5558570.
KEGG	vha:VIBHAR_06575.
PATRIC	20137290. VBIVibHar24526_5123.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	NEQLDHL.
ProtClustDB	PRK05321.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_VIBHB

Accession

Primary (citable) accession number: A7N4I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program