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A7N4I5

- PNCB_VIBCB

UniProt

A7N4I5 - PNCB_VIBCB

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-5560-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:VIBHAR_06575
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Nicotinate phosphoribosyltransferasePRO_1000025017Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_06575.

    Structurei

    3D structure databases

    ProteinModelPortaliA7N4I5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7N4I5-1 [UniParc]FASTAAdd to Basket

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    MTTNLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS    50
    ELLPEVKAEV LKLQDITFST EEIEYIKGVA PYLNPEFVDA LHAFRFNPQR 100
    DVSFNIKTMA DGTSQLRITI NGLWKETILY ETIIMSIVSE VRSRARWAEV 150
    PVEQFQSVLE EKVRHLKTEL KRRNITNFKF ADMSTRRRFS FQAQRSMLKY 200
    LSKELPDCLT GTSNYHLAKE LGLTPIGTVA HEWFMGHQAL VNVRDSQKVA 250
    LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSNAYVGV RHDSGCPYTW 300
    GEKMIEHYQS LGIDPMTKTL VFTDGLNFEQ ALAICEHFQD RVQVSFGIGT 350
    SLANDMGDYA NAQGIAYKPL SIVIKMVSCN GSPVAKISDE PEKAMCEDIF 400
    FLMNLKRRFE QPLDLDECRG LIDRLEDEGD NYLIDA 436
    Length:436
    Mass (Da):49,687
    Last modified:October 2, 2007 - v1
    Checksum:iB86A87652B4D6C1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74466.1.
    RefSeqiYP_001448693.1. NC_009784.1.
    YP_008528458.1. NC_022270.1.

    Genome annotation databases

    EnsemblBacteriaiABU74466; ABU74466; VIBHAR_06575.
    GeneIDi16818019.
    5558570.
    KEGGivca:M892_19485.
    vha:VIBHAR_06575.
    PATRICi20137290. VBIVibHar24526_5123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74466.1 .
    RefSeqi YP_001448693.1. NC_009784.1.
    YP_008528458.1. NC_022270.1.

    3D structure databases

    ProteinModelPortali A7N4I5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_06575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU74466 ; ABU74466 ; VIBHAR_06575 .
    GeneIDi 16818019.
    5558570.
    KEGGi vca:M892_19485.
    vha:VIBHAR_06575.
    PATRICi 20137290. VBIVibHar24526_5123.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci VHAR338187:GJCH-5560-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiPNCB_VIBCB
    AccessioniPrimary (citable) accession number: A7N4I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3