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A7N4I5

- PNCB_VIBCB

UniProt

A7N4I5 - PNCB_VIBCB

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, VIBHAR_06575
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-5560-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:VIBHAR_06575
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_1000025017Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_06575.

Structurei

3D structure databases

ProteinModelPortaliA7N4I5.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N4I5-1 [UniParc]FASTAAdd to Basket

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MTTNLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS    50
ELLPEVKAEV LKLQDITFST EEIEYIKGVA PYLNPEFVDA LHAFRFNPQR 100
DVSFNIKTMA DGTSQLRITI NGLWKETILY ETIIMSIVSE VRSRARWAEV 150
PVEQFQSVLE EKVRHLKTEL KRRNITNFKF ADMSTRRRFS FQAQRSMLKY 200
LSKELPDCLT GTSNYHLAKE LGLTPIGTVA HEWFMGHQAL VNVRDSQKVA 250
LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSNAYVGV RHDSGCPYTW 300
GEKMIEHYQS LGIDPMTKTL VFTDGLNFEQ ALAICEHFQD RVQVSFGIGT 350
SLANDMGDYA NAQGIAYKPL SIVIKMVSCN GSPVAKISDE PEKAMCEDIF 400
FLMNLKRRFE QPLDLDECRG LIDRLEDEGD NYLIDA 436
Length:436
Mass (Da):49,687
Last modified:October 2, 2007 - v1
Checksum:iB86A87652B4D6C1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74466.1.
RefSeqiYP_001448693.1. NC_009784.1.
YP_008528458.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU74466; ABU74466; VIBHAR_06575.
GeneIDi16818019.
5558570.
KEGGivca:M892_19485.
vha:VIBHAR_06575.
PATRICi20137290. VBIVibHar24526_5123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74466.1 .
RefSeqi YP_001448693.1. NC_009784.1.
YP_008528458.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N4I5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_06575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU74466 ; ABU74466 ; VIBHAR_06575 .
GeneIDi 16818019.
5558570.
KEGGi vca:M892_19485.
vha:VIBHAR_06575.
PATRICi 20137290. VBIVibHar24526_5123.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci VHAR338187:GJCH-5560-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiPNCB_VIBCB
AccessioniPrimary (citable) accession number: A7N4I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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