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A7N2Q0

- BETB_VIBCB

UniProt

A7N2Q0 - BETB_VIBCB

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene
betB, VIBHAR_06180
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1 By similarity
Metal bindingi90 – 901Potassium 1 By similarity
Active sitei159 – 1591Charge relay system By similarity
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygen By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei281 – 2811NAD/NADP By similarity
Binding sitei382 – 3821NAD/NADP By similarity
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygen By similarity
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygen By similarity
Active sitei459 – 4591Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADP By similarity
Nucleotide bindingi173 – 1764NAD/NADP By similarity
Nucleotide bindingi225 – 2306NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-5165-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:VIBHAR_06180
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotationPRO_1000047059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_06180.

Structurei

3D structure databases

ProteinModelPortaliA7N2Q0.
SMRiA7N2Q0. Positions 4-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7N2Q0-1 [UniParc]FASTAAdd to Basket

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MDMKAHYIDG AMHLGCSEEH FTTYNPANGE PLANVKQANQ QDMQAAIESA    50
KRGFAIWSAM TATERSRILL KAVALLRERN DELAALEVAD TGKPIQEANC 100
VDIATGADVI EYYAGLAPSM HGEQQPLNES QFFYTRREPL GICAGIGAWN 150
YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIYS EAGLPDGVFN 200
VIQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAAT LKQVTMELGG 250
KSPMIIFDDA KLDDAVSAAM VANFYTQGEV CTHGTRVFVH EGIYDEFVVQ 300
LKKRTELLVV GDPLDEQTQI GALISKEHES KVLSAIEQAK ASKATLLTGG 350
YKVTENGLAS GNFVVPTVFI DCEDDMPHVQ QEIFGPVMSV LKFSDEDEVI 400
ARANNTDYGL AAGVFTQNLS RAHRVIHQIQ AGICWINTWG DSPAEMPVGG 450
YKLSGIGREN GVETLTHYTQ TKSVLVHLGD FDSPYA 486
Length:486
Mass (Da):52,631
Last modified:October 2, 2007 - v1
Checksum:i532ADE6CD1F90AD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74072.1.
RefSeqiWP_012129669.1. NC_022270.1.
YP_001448299.1. NC_009784.1.
YP_008528779.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU74072; ABU74072; VIBHAR_06180.
GeneIDi16818341.
5558345.
KEGGivca:M892_21105.
vha:VIBHAR_06180.
PATRICi20136619. VBIVibHar24526_4788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74072.1 .
RefSeqi WP_012129669.1. NC_022270.1.
YP_001448299.1. NC_009784.1.
YP_008528779.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N2Q0.
SMRi A7N2Q0. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_06180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU74072 ; ABU74072 ; VIBHAR_06180 .
GeneIDi 16818341.
5558345.
KEGGi vca:M892_21105.
vha:VIBHAR_06180.
PATRICi 20136619. VBIVibHar24526_4788.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VHAR338187:GJCH-5165-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiBETB_VIBCB
AccessioniPrimary (citable) accession number: A7N2Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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