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A7N2Q0

- BETB_VIBCB

UniProt

A7N2Q0 - BETB_VIBCB

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Potassium 1UniRule annotation
    Metal bindingi90 – 901Potassium 1UniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei281 – 2811NAD/NADPUniRule annotation
    Binding sitei382 – 3821NAD/NADPUniRule annotation
    Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei459 – 4591Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
    Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
    Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-5165-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:VIBHAR_06180
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_06180.

    Structurei

    3D structure databases

    ProteinModelPortaliA7N2Q0.
    SMRiA7N2Q0. Positions 4-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7N2Q0-1 [UniParc]FASTAAdd to Basket

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    MDMKAHYIDG AMHLGCSEEH FTTYNPANGE PLANVKQANQ QDMQAAIESA    50
    KRGFAIWSAM TATERSRILL KAVALLRERN DELAALEVAD TGKPIQEANC 100
    VDIATGADVI EYYAGLAPSM HGEQQPLNES QFFYTRREPL GICAGIGAWN 150
    YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIYS EAGLPDGVFN 200
    VIQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAAT LKQVTMELGG 250
    KSPMIIFDDA KLDDAVSAAM VANFYTQGEV CTHGTRVFVH EGIYDEFVVQ 300
    LKKRTELLVV GDPLDEQTQI GALISKEHES KVLSAIEQAK ASKATLLTGG 350
    YKVTENGLAS GNFVVPTVFI DCEDDMPHVQ QEIFGPVMSV LKFSDEDEVI 400
    ARANNTDYGL AAGVFTQNLS RAHRVIHQIQ AGICWINTWG DSPAEMPVGG 450
    YKLSGIGREN GVETLTHYTQ TKSVLVHLGD FDSPYA 486
    Length:486
    Mass (Da):52,631
    Last modified:October 2, 2007 - v1
    Checksum:i532ADE6CD1F90AD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74072.1.
    RefSeqiWP_012129669.1. NC_022270.1.
    YP_001448299.1. NC_009784.1.
    YP_008528779.1. NC_022270.1.

    Genome annotation databases

    EnsemblBacteriaiABU74072; ABU74072; VIBHAR_06180.
    GeneIDi16818341.
    5558345.
    KEGGivca:M892_21105.
    vha:VIBHAR_06180.
    PATRICi20136619. VBIVibHar24526_4788.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74072.1 .
    RefSeqi WP_012129669.1. NC_022270.1.
    YP_001448299.1. NC_009784.1.
    YP_008528779.1. NC_022270.1.

    3D structure databases

    ProteinModelPortali A7N2Q0.
    SMRi A7N2Q0. Positions 4-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_06180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU74072 ; ABU74072 ; VIBHAR_06180 .
    GeneIDi 16818341.
    5558345.
    KEGGi vca:M892_21105.
    vha:VIBHAR_06180.
    PATRICi 20136619. VBIVibHar24526_4788.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci VHAR338187:GJCH-5165-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiBETB_VIBCB
    AccessioniPrimary (citable) accession number: A7N2Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3