Reviewed, UniProtKB/Swiss-Prot A7N2Q0 (BETB_VIBHB)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	VIBHAR_06180

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Betaine aldehyde dehydrogenase		PRO_1000047059
Regions
	Nucleotide binding	225 – 230	6	NAD By similarity
Sites
	Active site	247	1	By similarity
	Active site	281	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7N2Q0-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 532ADE6CD1F90AD8	FASTA	486	52,631
	10 20 30 40 50 60 MDMKAHYIDG AMHLGCSEEH FTTYNPANGE PLANVKQANQ QDMQAAIESA KRGFAIWSAM 70 80 90 100 110 120 TATERSRILL KAVALLRERN DELAALEVAD TGKPIQEANC VDIATGADVI EYYAGLAPSM 130 140 150 160 170 180 HGEQQPLNES QFFYTRREPL GICAGIGAWN YPIQIAMWKS APALAAGNAM IFKPSEETPL 190 200 210 220 230 240 TALKLAEIYS EAGLPDGVFN VIQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAAT 250 260 270 280 290 300 LKQVTMELGG KSPMIIFDDA KLDDAVSAAM VANFYTQGEV CTHGTRVFVH EGIYDEFVVQ 310 320 330 340 350 360 LKKRTELLVV GDPLDEQTQI GALISKEHES KVLSAIEQAK ASKATLLTGG YKVTENGLAS 370 380 390 400 410 420 GNFVVPTVFI DCEDDMPHVQ QEIFGPVMSV LKFSDEDEVI ARANNTDYGL AAGVFTQNLS 430 440 450 460 470 480 RAHRVIHQIQ AGICWINTWG DSPAEMPVGG YKLSGIGREN GVETLTHYTQ TKSVLVHLGD FDSPYA

References

[1]

Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000790 Genomic DNA. Translation: ABU74072.1.
RefSeq	YP_001448299.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5558345.
GenomeReviews	Gene locus VIBHAR_06180 in contig CP000790_GR.
KEGG	vha:VIBHAR_06180.
NMPDR	fig|338187.4.peg.3648.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_VIBHB

Accession

Primary (citable) accession number: A7N2Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	November 4, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)