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A7N2Q0

- BETB_VIBCB

UniProt

A7N2Q0 - BETB_VIBCB

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K(+)UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1UniRule annotation
Metal bindingi90 – 901Potassium 1UniRule annotation
Active sitei159 – 1591Charge relay systemUniRule annotation
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei247 – 2471Proton acceptorUniRule annotation
Binding sitei281 – 2811NAD/NADPUniRule annotation
Binding sitei382 – 3821NAD/NADPUniRule annotation
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei459 – 4591Charge relay systemUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-5165-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:VIBHAR_06180
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_06180.

Structurei

3D structure databases

ProteinModelPortaliA7N2Q0.
SMRiA7N2Q0. Positions 4-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7N2Q0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMKAHYIDG AMHLGCSEEH FTTYNPANGE PLANVKQANQ QDMQAAIESA
60 70 80 90 100
KRGFAIWSAM TATERSRILL KAVALLRERN DELAALEVAD TGKPIQEANC
110 120 130 140 150
VDIATGADVI EYYAGLAPSM HGEQQPLNES QFFYTRREPL GICAGIGAWN
160 170 180 190 200
YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIYS EAGLPDGVFN
210 220 230 240 250
VIQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAAT LKQVTMELGG
260 270 280 290 300
KSPMIIFDDA KLDDAVSAAM VANFYTQGEV CTHGTRVFVH EGIYDEFVVQ
310 320 330 340 350
LKKRTELLVV GDPLDEQTQI GALISKEHES KVLSAIEQAK ASKATLLTGG
360 370 380 390 400
YKVTENGLAS GNFVVPTVFI DCEDDMPHVQ QEIFGPVMSV LKFSDEDEVI
410 420 430 440 450
ARANNTDYGL AAGVFTQNLS RAHRVIHQIQ AGICWINTWG DSPAEMPVGG
460 470 480
YKLSGIGREN GVETLTHYTQ TKSVLVHLGD FDSPYA
Length:486
Mass (Da):52,631
Last modified:October 2, 2007 - v1
Checksum:i532ADE6CD1F90AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000790 Genomic DNA. Translation: ABU74072.1.
RefSeqiYP_001448299.1. NC_009784.1.
YP_008528779.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU74072; ABU74072; VIBHAR_06180.
GeneIDi16818341.
5558345.
KEGGivca:M892_21105.
vha:VIBHAR_06180.
PATRICi20136619. VBIVibHar24526_4788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000790 Genomic DNA. Translation: ABU74072.1 .
RefSeqi YP_001448299.1. NC_009784.1.
YP_008528779.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N2Q0.
SMRi A7N2Q0. Positions 4-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_06180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU74072 ; ABU74072 ; VIBHAR_06180 .
GeneIDi 16818341.
5558345.
KEGGi vca:M892_21105.
vha:VIBHAR_06180.
PATRICi 20136619. VBIVibHar24526_4788.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VHAR338187:GJCH-5165-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiBETB_VIBCB
AccessioniPrimary (citable) accession number: A7N2Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3