Reviewed, UniProtKB/Swiss-Prot A7N2P9 (BETA_VIBHB)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	VIBHAR_06179

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1.
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular alcohol metabolic process Inferred from electronic annotation. Source: InterPro glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Choline dehydrogenase		PRO_1000046574
Regions
	Nucleotide binding	6 – 35	30	FAD Probable
Sites
	Active site	470	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7N2P9-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 38EEEB2710D68C15	FASTA	569	62,529
	10 20 30 40 50 60 MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA LSYPMNTEKY 70 80 90 100 110 120 AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEAE GAKGWNYQAC 130 140 150 160 170 180 LPYFRKAETW TGGADEYRGG SGPVGTCNGN DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ 190 200 210 220 230 240 QEGFGPMHMT VDKGVRASTS NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG 250 260 270 280 290 300 EIKQCFANKE VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY 310 320 330 340 350 360 FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE GLKSPNIQFH 370 380 390 400 410 420 FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN PNDKPKIEFN YISTEQDKQD 430 440 450 460 470 480 WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN ITSDEAIGEW VKQNVESAYH PSCSCKMGSN 490 500 510 520 530 540 DDPMAVLNEA CQVRGIEGLR VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN 550 560 TPVWIAPNWQ ETQRMRPPKR DLSSISSIA

References

[1]

Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000790 Genomic DNA. Translation: ABU74071.1.
RefSeq	YP_001448298.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5558185.
GenomeReviews	Gene locus VIBHAR_06179 in contig CP000790_GR.
KEGG	vha:VIBHAR_06179.
NMPDR	fig|338187.4.peg.3647.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_VIBHB

Accession

Primary (citable) accession number: A7N2P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)