A7N2P9 (BETA_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	VIBHAR_06179

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Choline dehydrogenase HAMAP MF_00750		PRO_1000046574
Regions
	Nucleotide binding	6 – 35	30	FAD Potential
Sites
	Active site	470	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7N2P9 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 38EEEB2710D68C15	FASTA	569	62,529
	10 20 30 40 50 60 MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA LSYPMNTEKY 70 80 90 100 110 120 AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEAE GAKGWNYQAC 130 140 150 160 170 180 LPYFRKAETW TGGADEYRGG SGPVGTCNGN DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ 190 200 210 220 230 240 QEGFGPMHMT VDKGVRASTS NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG 250 260 270 280 290 300 EIKQCFANKE VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY 310 320 330 340 350 360 FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE GLKSPNIQFH 370 380 390 400 410 420 FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN PNDKPKIEFN YISTEQDKQD 430 440 450 460 470 480 WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN ITSDEAIGEW VKQNVESAYH PSCSCKMGSN 490 500 510 520 530 540 DDPMAVLNEA CQVRGIEGLR VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN 550 560 TPVWIAPNWQ ETQRMRPPKR DLSSISSIA

References

[1]

The Vibrio harveyi Genome Sequencing Project Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000790 Genomic DNA. Translation: ABU74071.1.
RefSeq	YP_001448298.1. NC_009784.1.
3D structure databases
ProteinModelPortal	A7N2P9.
ModBase	Search...
Protein-protein interaction databases
STRING	A7N2P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5558185.
GenomeReviews	Gene locus VIBHAR_06179 in contig CP000790_GR.
KEGG	vha:VIBHAR_06179.
NMPDR	fig|338187.4.peg.3647.
PATRIC	20136617. VBIVibHar24526_4787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2303.
HOGENOM	HBG734713.
OMA	HMTVKNG.
ProtClustDB	PRK02106.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_VIBHB

Accession

Primary (citable) accession number: A7N2P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program