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A7N2P9

- BETA_VIBCB

UniProt

A7N2P9 - BETA_VIBCB

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei470 – 4701UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-5164-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:VIBHAR_06179
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 569569Oxygen-dependent choline dehydrogenasePRO_1000046574Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_06179.

    Structurei

    3D structure databases

    ProteinModelPortaliA7N2P9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7N2P9-1 [UniParc]FASTAAdd to Basket

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    MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA    50
    LSYPMNTEKY AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH 100
    ACDFDEWEAE GAKGWNYQAC LPYFRKAETW TGGADEYRGG SGPVGTCNGN 150
    DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ QEGFGPMHMT VDKGVRASTS 200
    NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG EIKQCFANKE 250
    VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY 300
    FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE 350
    GLKSPNIQFH FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN 400
    PNDKPKIEFN YISTEQDKQD WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN 450
    ITSDEAIGEW VKQNVESAYH PSCSCKMGSN DDPMAVLNEA CQVRGIEGLR 500
    VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN TPVWIAPNWQ 550
    ETQRMRPPKR DLSSISSIA 569
    Length:569
    Mass (Da):62,529
    Last modified:October 2, 2007 - v1
    Checksum:i38EEEB2710D68C15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74071.1.
    RefSeqiWP_012129668.1. NC_022270.1.
    YP_001448298.1. NC_009784.1.
    YP_008528780.1. NC_022270.1.

    Genome annotation databases

    EnsemblBacteriaiABU74071; ABU74071; VIBHAR_06179.
    GeneIDi16818342.
    5558185.
    KEGGivca:M892_21110.
    vha:VIBHAR_06179.
    PATRICi20136617. VBIVibHar24526_4787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000790 Genomic DNA. Translation: ABU74071.1 .
    RefSeqi WP_012129668.1. NC_022270.1.
    YP_001448298.1. NC_009784.1.
    YP_008528780.1. NC_022270.1.

    3D structure databases

    ProteinModelPortali A7N2P9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_06179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU74071 ; ABU74071 ; VIBHAR_06179 .
    GeneIDi 16818342.
    5558185.
    KEGGi vca:M892_21110.
    vha:VIBHAR_06179.
    PATRICi 20136617. VBIVibHar24526_4787.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci VHAR338187:GJCH-5164-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiBETA_VIBCB
    AccessioniPrimary (citable) accession number: A7N2P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3