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A7N2P9 (BETA_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:VIBHAR_06179
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length569 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 569569Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000046574

Regions

Nucleotide binding6 – 3530FAD By similarity

Sites

Active site4701 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7N2P9 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 38EEEB2710D68C15

FASTA56962,529
        10         20         30         40         50         60 
MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA LSYPMNTEKY 

        70         80         90        100        110        120 
AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH ACDFDEWEAE GAKGWNYQAC 

       130        140        150        160        170        180 
LPYFRKAETW TGGADEYRGG SGPVGTCNGN DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ 

       190        200        210        220        230        240 
QEGFGPMHMT VDKGVRASTS NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG 

       250        260        270        280        290        300 
EIKQCFANKE VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY 

       310        320        330        340        350        360 
FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE GLKSPNIQFH 

       370        380        390        400        410        420 
FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN PNDKPKIEFN YISTEQDKQD 

       430        440        450        460        470        480 
WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN ITSDEAIGEW VKQNVESAYH PSCSCKMGSN 

       490        500        510        520        530        540 
DDPMAVLNEA CQVRGIEGLR VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN 

       550        560 
TPVWIAPNWQ ETQRMRPPKR DLSSISSIA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000790 Genomic DNA. Translation: ABU74071.1.
RefSeqYP_001448298.1. NC_009784.1.
YP_008528780.1. NC_022270.1.

3D structure databases

ProteinModelPortalA7N2P9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_06179.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU74071; ABU74071; VIBHAR_06179.
GeneID16818342.
5558185.
KEGGvca:M892_21110.
vha:VIBHAR_06179.
PATRIC20136617. VBIVibHar24526_4787.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-5164-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_VIBCB
AccessionPrimary (citable) accession number: A7N2P9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways