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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei470Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 35FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciVCAM338187:G1HKJ-4213-MONOMER
UniPathwayiUPA00529; UER00385

Protein family/group databases

CAZyiAA3 Auxiliary Activities 3

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:VIBHAR_06179
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000008152 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000465741 – 569Oxygen-dependent choline dehydrogenaseAdd BLAST569

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_06179

Structurei

3D structure databases

ProteinModelPortaliA7N2P9
SMRiA7N2P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC

Family and domain databases

Gene3Di3.50.50.604 hits
4.10.450.102 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit

Sequencei

Sequence statusi: Complete.

A7N2P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA
60 70 80 90 100
LSYPMNTEKY AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH
110 120 130 140 150
ACDFDEWEAE GAKGWNYQAC LPYFRKAETW TGGADEYRGG SGPVGTCNGN
160 170 180 190 200
DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ QEGFGPMHMT VDKGVRASTS
210 220 230 240 250
NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG EIKQCFANKE
260 270 280 290 300
VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY
310 320 330 340 350
FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE
360 370 380 390 400
GLKSPNIQFH FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN
410 420 430 440 450
PNDKPKIEFN YISTEQDKQD WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN
460 470 480 490 500
ITSDEAIGEW VKQNVESAYH PSCSCKMGSN DDPMAVLNEA CQVRGIEGLR
510 520 530 540 550
VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN TPVWIAPNWQ
560
ETQRMRPPKR DLSSISSIA
Length:569
Mass (Da):62,529
Last modified:October 2, 2007 - v1
Checksum:i38EEEB2710D68C15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000790 Genomic DNA Translation: ABU74071.1
RefSeqiWP_012129668.1, NC_022270.1

Genome annotation databases

EnsemblBacteriaiABU74071; ABU74071; VIBHAR_06179
GeneIDi5558185
KEGGivca:M892_21110
vha:VIBHAR_06179
PATRICifig|338187.25.peg.4151

Similar proteinsi

Entry informationi

Entry nameiBETA_VIBCB
AccessioniPrimary (citable) accession number: A7N2P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome