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A7N2P9

- BETA_VIBCB

UniProt

A7N2P9 - BETA_VIBCB

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, VIBHAR_06179
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei470 – 4701 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-5164-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:VIBHAR_06179
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 569569Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_1000046574Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_06179.

Structurei

3D structure databases

ProteinModelPortaliA7N2P9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7N2P9-1 [UniParc]FASTAAdd to Basket

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MQQHYDYIIV GAGSAGCVLA DRLSESGQHQ VLLLEAGGSD KSIFIQMPTA    50
LSYPMNTEKY AWQFETVAEE GLDGRQLHCP RGKVLGGSSS INGMVYVRGH 100
ACDFDEWEAE GAKGWNYQAC LPYFRKAETW TGGADEYRGG SGPVGTCNGN 150
DMKLNPLYQA FIEAGKDAGY PETQDYNGYQ QEGFGPMHMT VDKGVRASTS 200
NAYLSRAKKR SNFTLMKGVT AHRILLEGKK AVGIEFEQSG EIKQCFANKE 250
VVSSAGSIGS VQLLQLSGIG PKTVLDKAGI EVKHTLEGVG KNLQDHLEVY 300
FQYHCKQPIT LNSKLGLISK GLIGTEWILT RKGLGATNHF ESCAFIRSRE 350
GLKSPNIQFH FLPAAMRYDG RAAFDGHGFQ VHVGPNKPES RGSVEVVSAN 400
PNDKPKIEFN YISTEQDKQD WRDCIRLTRE ILNQPAMDAF RGEEIQPGLN 450
ITSDEAIGEW VKQNVESAYH PSCSCKMGSN DDPMAVLNEA CQVRGIEGLR 500
VVDSSIFPTI PNGNLNAPTI MVAERAADMI LGNTLEQSNN TPVWIAPNWQ 550
ETQRMRPPKR DLSSISSIA 569
Length:569
Mass (Da):62,529
Last modified:October 2, 2007 - v1
Checksum:i38EEEB2710D68C15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74071.1.
RefSeqiWP_012129668.1. NC_022270.1.
YP_001448298.1. NC_009784.1.
YP_008528780.1. NC_022270.1.

Genome annotation databases

EnsemblBacteriaiABU74071; ABU74071; VIBHAR_06179.
GeneIDi16818342.
5558185.
KEGGivca:M892_21110.
vha:VIBHAR_06179.
PATRICi20136617. VBIVibHar24526_4787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000790 Genomic DNA. Translation: ABU74071.1 .
RefSeqi WP_012129668.1. NC_022270.1.
YP_001448298.1. NC_009784.1.
YP_008528780.1. NC_022270.1.

3D structure databases

ProteinModelPortali A7N2P9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_06179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU74071 ; ABU74071 ; VIBHAR_06179 .
GeneIDi 16818342.
5558185.
KEGGi vca:M892_21110.
vha:VIBHAR_06179.
PATRICi 20136617. VBIVibHar24526_4787.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci VHAR338187:GJCH-5164-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiBETA_VIBCB
AccessioniPrimary (citable) accession number: A7N2P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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