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A7N1N0

- A7N1N0_VIBCB

UniProt

A7N1N0 - A7N1N0_VIBCB

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

VIBHAR_01563

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471Substrate
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491Substrate
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
    Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-1553-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Ordered Locus Names:VIBHAR_01563Imported
    ORF Names:M892_05310Imported
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)Imported
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome I

    Interactioni

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_01563.

    Structurei

    3D structure databases

    SMRiA7N1N0. Positions 6-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OrthoDBiEOG6DVJPP.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7N1N0-1 [UniParc]FASTAAdd to Basket

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    MPTEKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVD TRDISLAGRI    50
    IANFPEHLKE DQRIGDALAE LGELAKTPEA NIIKLPNISA SIPQLKAAIK 100
    ELQAKGYELP NYPEEPSTYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP 150
    LSVKNYAKKN PHSMGAWSAD SQSHVSSMAD NDFFGSEKST TISGATDVKI 200
    EFVAADGSVK ELKSAFPLQD KEVIDCAVMN KKALVEFFEK EIAEAKQQDV 250
    LLSLHMKATM MKVSDPVIFG HAVKVYYKDV FAKYGKLFEE LGVDVNNGIG 300
    DVYAKIEALP AEQKAEIEAA ILAVYETQPA LAMVDSDRGI TNLHVPSDII 350
    VDASMPAMLR ASGQMWGPDG KQKDTKAMIP DRSYAAIYQA VIDFCKEHGA 400
    FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAAGSVRVV AASGAVLLEQ 450
    AVEEGDIFRM CQVKDAPIQD WVKLAVTRAR ASGAPAVFWL DEARAHDAEL 500
    IKKVNAHLPE HDTSGLEIKI LAPIDACKFS LERIKEGLDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKENH 600
    LRWDSLGEFL ALAASLEHLS TVAGNAKAQV LADALDKATG EFLDNNKSPS 650
    RKVGELDNRG SHYYLASYWA KALAEQTADA DLAAEFVPVA AALAQQEEAI 700
    VSELNNAQGV KGELGGYYSL DDALASTLMR PSATLNAIIN K 741
    Length:741
    Mass (Da):79,986
    Last modified:October 2, 2007 - v1
    Checksum:i8F25295125ECB865
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU70533.1.
    CP006605 Genomic DNA. Translation: AGU94215.1.
    RefSeqiWP_012127421.1. NC_022269.1.
    YP_001444760.1. NC_009783.1.
    YP_008525840.1. NC_022269.1.

    Genome annotation databases

    EnsemblBacteriaiABU70533; ABU70533; VIBHAR_01563.
    AGU94215; AGU94215; M892_05310.
    GeneIDi16815233.
    5553350.
    KEGGivca:M892_05310.
    vha:VIBHAR_01563.
    PATRICi20129925. VBIVibHar24526_1505.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU70533.1 .
    CP006605 Genomic DNA. Translation: AGU94215.1 .
    RefSeqi WP_012127421.1. NC_022269.1.
    YP_001444760.1. NC_009783.1.
    YP_008525840.1. NC_022269.1.

    3D structure databases

    SMRi A7N1N0. Positions 6-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_01563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU70533 ; ABU70533 ; VIBHAR_01563 .
    AGU94215 ; AGU94215 ; M892_05310 .
    GeneIDi 16815233.
    5553350.
    KEGGi vca:M892_05310.
    vha:VIBHAR_01563.
    PATRICi 20129925. VBIVibHar24526_1505.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OrthoDBi EOG6DVJPP.

    Enzyme and pathway databases

    BioCyci VHAR338187:GJCH-1553-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116Imported and ATCC BAA-1116 / BB120Imported.
    2. "Vibrio campbellii hmgA-mediated pyomelanization impairs quorum sensing, virulence, and cellular fitness."
      Wang Z., Lin B., Mostaghim A., Rubin R.A., Glaser E.R., Mittraparp-Arthorn P., Thompson J.R., Vuddhakul V., Vora G.J.
      Front. Microbiol. 4:379-379(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC BAA-1116Imported.

    Entry informationi

    Entry nameiA7N1N0_VIBCB
    AccessioniPrimary (citable) accession number: A7N1N0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3