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A7N1N0

- A7N1N0_VIBCB

UniProt

A7N1N0 - A7N1N0_VIBCB

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Protein
Submitted name: Isocitrate dehydrogenase
Gene
VIBHAR_01563, M892_05310
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarityUniRule annotation
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei549 – 5491Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation
Metal bindingi554 – 5541Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1553-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:VIBHAR_01563Imported
ORF Names:M892_05310Imported
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)Imported
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_01563.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarityUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N1N0-1 [UniParc]FASTAAdd to Basket

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MPTEKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVD TRDISLAGRI    50
IANFPEHLKE DQRIGDALAE LGELAKTPEA NIIKLPNISA SIPQLKAAIK 100
ELQAKGYELP NYPEEPSTYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP 150
LSVKNYAKKN PHSMGAWSAD SQSHVSSMAD NDFFGSEKST TISGATDVKI 200
EFVAADGSVK ELKSAFPLQD KEVIDCAVMN KKALVEFFEK EIAEAKQQDV 250
LLSLHMKATM MKVSDPVIFG HAVKVYYKDV FAKYGKLFEE LGVDVNNGIG 300
DVYAKIEALP AEQKAEIEAA ILAVYETQPA LAMVDSDRGI TNLHVPSDII 350
VDASMPAMLR ASGQMWGPDG KQKDTKAMIP DRSYAAIYQA VIDFCKEHGA 400
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAAGSVRVV AASGAVLLEQ 450
AVEEGDIFRM CQVKDAPIQD WVKLAVTRAR ASGAPAVFWL DEARAHDAEL 500
IKKVNAHLPE HDTSGLEIKI LAPIDACKFS LERIKEGLDT ISVTGNVLRD 550
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKENH 600
LRWDSLGEFL ALAASLEHLS TVAGNAKAQV LADALDKATG EFLDNNKSPS 650
RKVGELDNRG SHYYLASYWA KALAEQTADA DLAAEFVPVA AALAQQEEAI 700
VSELNNAQGV KGELGGYYSL DDALASTLMR PSATLNAIIN K 741
Length:741
Mass (Da):79,986
Last modified:October 2, 2007 - v1
Checksum:i8F25295125ECB865
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70533.1.
CP006605 Genomic DNA. Translation: AGU94215.1.
RefSeqiWP_012127421.1. NC_022269.1.
YP_001444760.1. NC_009783.1.
YP_008525840.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU70533; ABU70533; VIBHAR_01563.
AGU94215; AGU94215; M892_05310.
GeneIDi16815233.
5553350.
KEGGivca:M892_05310.
vha:VIBHAR_01563.
PATRICi20129925. VBIVibHar24526_1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70533.1 .
CP006605 Genomic DNA. Translation: AGU94215.1 .
RefSeqi WP_012127421.1. NC_022269.1.
YP_001444760.1. NC_009783.1.
YP_008525840.1. NC_022269.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_01563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU70533 ; ABU70533 ; VIBHAR_01563 .
AGU94215 ; AGU94215 ; M892_05310 .
GeneIDi 16815233.
5553350.
KEGGi vca:M892_05310.
vha:VIBHAR_01563.
PATRICi 20129925. VBIVibHar24526_1505.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-1553-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116Imported and ATCC BAA-1116 / BB120.
  2. "Vibrio campbellii hmgA-mediated pyomelanization impairs quorum sensing, virulence, and cellular fitness."
    Wang Z., Lin B., Mostaghim A., Rubin R.A., Glaser E.R., Mittraparp-Arthorn P., Thompson J.R., Vuddhakul V., Vora G.J.
    Front. Microbiol. 4:379-379(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC BAA-1116Imported.

Entry informationi

Entry nameiA7N1N0_VIBCB
AccessioniPrimary (citable) accession number: A7N1N0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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