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A7N1N0

- A7N1N0_VIBCB

UniProt

A7N1N0 - A7N1N0_VIBCB

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

VIBHAR_01563

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysis
Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1553-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Submitted name:
Uncharacterized proteinImported
Gene namesi
Ordered Locus Names:VIBHAR_01563Imported
ORF Names:M892_05310Imported
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)Imported
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_01563.

Structurei

3D structure databases

ProteinModelPortaliA7N1N0.
SMRiA7N1N0. Positions 6-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N1N0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTEKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVD TRDISLAGRI
60 70 80 90 100
IANFPEHLKE DQRIGDALAE LGELAKTPEA NIIKLPNISA SIPQLKAAIK
110 120 130 140 150
ELQAKGYELP NYPEEPSTYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
LSVKNYAKKN PHSMGAWSAD SQSHVSSMAD NDFFGSEKST TISGATDVKI
210 220 230 240 250
EFVAADGSVK ELKSAFPLQD KEVIDCAVMN KKALVEFFEK EIAEAKQQDV
260 270 280 290 300
LLSLHMKATM MKVSDPVIFG HAVKVYYKDV FAKYGKLFEE LGVDVNNGIG
310 320 330 340 350
DVYAKIEALP AEQKAEIEAA ILAVYETQPA LAMVDSDRGI TNLHVPSDII
360 370 380 390 400
VDASMPAMLR ASGQMWGPDG KQKDTKAMIP DRSYAAIYQA VIDFCKEHGA
410 420 430 440 450
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAAGSVRVV AASGAVLLEQ
460 470 480 490 500
AVEEGDIFRM CQVKDAPIQD WVKLAVTRAR ASGAPAVFWL DEARAHDAEL
510 520 530 540 550
IKKVNAHLPE HDTSGLEIKI LAPIDACKFS LERIKEGLDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVEKENH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS TVAGNAKAQV LADALDKATG EFLDNNKSPS
660 670 680 690 700
RKVGELDNRG SHYYLASYWA KALAEQTADA DLAAEFVPVA AALAQQEEAI
710 720 730 740
VSELNNAQGV KGELGGYYSL DDALASTLMR PSATLNAIIN K
Length:741
Mass (Da):79,986
Last modified:October 2, 2007 - v1
Checksum:i8F25295125ECB865
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70533.1.
CP006605 Genomic DNA. Translation: AGU94215.1.
RefSeqiYP_001444760.1. NC_009783.1.
YP_008525840.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU70533; ABU70533; VIBHAR_01563.
AGU94215; AGU94215; M892_05310.
GeneIDi16815233.
5553350.
KEGGivca:M892_05310.
vha:VIBHAR_01563.
PATRICi20129925. VBIVibHar24526_1505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70533.1 .
CP006605 Genomic DNA. Translation: AGU94215.1 .
RefSeqi YP_001444760.1. NC_009783.1.
YP_008525840.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7N1N0.
SMRi A7N1N0. Positions 6-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_01563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU70533 ; ABU70533 ; VIBHAR_01563 .
AGU94215 ; AGU94215 ; M892_05310 .
GeneIDi 16815233.
5553350.
KEGGi vca:M892_05310.
vha:VIBHAR_01563.
PATRICi 20129925. VBIVibHar24526_1505.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OrthoDBi EOG6DVJPP.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-1553-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116Imported and ATCC BAA-1116 / BB120Imported.
  2. "Vibrio campbellii hmgA-mediated pyomelanization impairs quorum sensing, virulence, and cellular fitness."
    Wang Z., Lin B., Mostaghim A., Rubin R.A., Glaser E.R., Mittraparp-Arthorn P., Thompson J.R., Vuddhakul V., Vora G.J.
    Front. Microbiol. 4:379-379(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC BAA-1116Imported.

Entry informationi

Entry nameiA7N1N0_VIBCB
AccessioniPrimary (citable) accession number: A7N1N0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3