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Protein

Ribosomal RNA large subunit methyltransferase F

Gene

rlmF

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the adenine in position 1618 of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase FUniRule annotation (EC:2.1.1.181UniRule annotation)
Alternative name(s):
23S rRNA mA1618 methyltransferaseUniRule annotation
rRNA adenine N-6-methyltransferaseUniRule annotation
Gene namesi
Name:rlmFUniRule annotation
Ordered Locus Names:VIBHAR_02145
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000008152 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003499761 – 388Ribosomal RNA large subunit methyltransferase FAdd BLAST388

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_02145.

Structurei

3D structure databases

ProteinModelPortaliA7N060.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. METTL16/RlmF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EBA. Bacteria.
COG3129. LUCA.
HOGENOMiHOG000218605.
KOiK06970.
OMAiTEFHQGH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01848. 23SrRNA_methyltr_F. 1 hit.
InterProiIPR016909. rRNA_lsu_MeTfrase_F.
IPR010286. rRNA_lsu_MeTfrase_F-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13393. PTHR13393. 2 hits.
PfamiPF05971. Methyltransf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF029038. Mtase_YbiN_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

A7N060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTNNHNAKQ AQTKTAKSNP SKEVTKIKPK RVKNKPTAKA AKSTGLKTNA
60 70 80 90 100
ANESSDVEVI KTAKSGLHER NAHRGRYDFK KLIAAEPQLK SFVIKNPKGE
110 120 130 140 150
DSINFSDPKA VKMLNKALLA AHYDIEYWDI PDTYLCPPIP GRADYVHRVA
160 170 180 190 200
ELLDGEVKGK YAHHKVRALD VGVGANCIYP IVGVTQYGWH YTGSDVDPKS
210 220 230 240 250
IESARTIVER NVSLNGKIEL RQQTSESNIY RGIIQPNDRY DITTCNPPFH
260 270 280 290 300
RSAEEAAMGS QRKLDNLKAN QRKKGVKVQA HQAKTPQVKA NKPALNFGGQ
310 320 330 340 350
NAELWCEGGE AAFIRKMANE SQAFSAQVLW FTTLISKKDN VRPMRKQLEK
360 370 380
LGVKAIRIVE MSQGQKVSRF MAWSYMDKAQ RKAWIELK
Length:388
Mass (Da):43,524
Last modified:October 2, 2007 - v1
Checksum:i8F8F6152135E5705
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU71110.1.
RefSeqiWP_012127863.1. NC_009783.1.

Genome annotation databases

EnsemblBacteriaiABU71110; ABU71110; VIBHAR_02145.
GeneIDi5554830.
KEGGivha:VIBHAR_02145.
PATRICi20131034. VBIVibHar24526_2058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU71110.1.
RefSeqiWP_012127863.1. NC_009783.1.

3D structure databases

ProteinModelPortaliA7N060.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338187.VIBHAR_02145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU71110; ABU71110; VIBHAR_02145.
GeneIDi5554830.
KEGGivha:VIBHAR_02145.
PATRICi20131034. VBIVibHar24526_2058.

Phylogenomic databases

eggNOGiENOG4105EBA. Bacteria.
COG3129. LUCA.
HOGENOMiHOG000218605.
KOiK06970.
OMAiTEFHQGH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01848. 23SrRNA_methyltr_F. 1 hit.
InterProiIPR016909. rRNA_lsu_MeTfrase_F.
IPR010286. rRNA_lsu_MeTfrase_F-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR13393. PTHR13393. 2 hits.
PfamiPF05971. Methyltransf_10. 1 hit.
[Graphical view]
PIRSFiPIRSF029038. Mtase_YbiN_prd. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMF_VIBCB
AccessioniPrimary (citable) accession number: A7N060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.