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Protein

Glutamate decarboxylase

Gene

VIBHAR_03063

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-3054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:VIBHAR_03063Imported
ORF Names:M892_15715Imported
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)Imported
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_03063.

Structurei

3D structure databases

ProteinModelPortaliA7MZW2.
SMRiA7MZW2. Positions 8-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MZW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLHKKSALK GSILDDVYCS KDLSIVMPKY RIPENEHAAS HAYQVVHDEL
60 70 80 90 100
MLDGNSRQNL ATFCQTWAED EVHKLMDECI DKNMIDKDEY PQTAEIESRC
110 120 130 140 150
VHMLADLWHA PHAENPMGCS TTGSSEAAML GGMALKWAWR EKMKKQGKPT
160 170 180 190 200
DRPNLICGPV QVCWHKFARY WDIELREIPM QGDRLIMTPE EVIKRCDENT
210 220 230 240 250
IGVVPTLGVT FTCQYEPVKE VHDALDRLQE ETGLDIPIHV DGASGAFLAP
260 270 280 290 300
FCDPDLVWDF RLPRVKSINA SGHKFGLSPL GVGWVVWRDA DALHEDLIFN
310 320 330 340 350
VNYLGGNMPT FALNFSRPGG QIVAQYYNFL RLGREGYRKI HEACYDTARY
360 370 380 390 400
LAQEIEKMGM FHIIYDGHGG IPALSWSIKE GANPGFNLYD LSDRIRSRGW
410 420 430 440 450
QIAAYAMPAE REDLVIMRIL VRHGFSRDLA DLLITDLQHC VDFFDKHPVV
460
NGSDADESSN FNHG
Length:464
Mass (Da):52,580
Last modified:October 2, 2007 - v1
Checksum:iBAFB5AE3BCADFD05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU72013.1.
CP006605 Genomic DNA. Translation: AGU96887.1.
RefSeqiWP_012128575.1. NC_022269.1.
YP_001446241.1. NC_009783.1.
YP_008527809.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU72013; ABU72013; VIBHAR_03063.
AGU96887; AGU96887; M892_15715.
GeneIDi16817307.
5553098.
KEGGivca:M892_15715.
vha:VIBHAR_03063.
PATRICi20132772. VBIVibHar24526_2916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU72013.1.
CP006605 Genomic DNA. Translation: AGU96887.1.
RefSeqiWP_012128575.1. NC_022269.1.
YP_001446241.1. NC_009783.1.
YP_008527809.1. NC_022269.1.

3D structure databases

ProteinModelPortaliA7MZW2.
SMRiA7MZW2. Positions 8-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338187.VIBHAR_03063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU72013; ABU72013; VIBHAR_03063.
AGU96887; AGU96887; M892_15715.
GeneIDi16817307.
5553098.
KEGGivca:M892_15715.
vha:VIBHAR_03063.
PATRICi20132772. VBIVibHar24526_2916.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-3054-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116Imported and ATCC BAA-1116 / BB120Imported.
  2. "Vibrio campbellii hmgA-mediated pyomelanization impairs quorum sensing, virulence, and cellular fitness."
    Wang Z., Lin B., Mostaghim A., Rubin R.A., Glaser E.R., Mittraparp-Arthorn P., Thompson J.R., Vuddhakul V., Vora G.J.
    Front. Microbiol. 4:379-379(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC BAA-1116Imported.

Entry informationi

Entry nameiA7MZW2_VIBCB
AccessioniPrimary (citable) accession number: A7MZW2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: February 4, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.