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A7MZM6 (RLMI_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase I
EC=2.1.1.191
Alternative name(s):
23S rRNA m5C1962 methyltransferase
rRNA (cytosine-C(5)-)-methyltransferase RlmI
Gene names
Name:rlmI
Ordered Locus Names:VIBHAR_02370
OrganismVibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA By similarity. HAMAP-Rule MF_01857

Catalytic activity

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA. HAMAP-Rule MF_01857

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01857.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmI family.

Contains 1 PUA domain.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

rRNA (cytosine) methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 397397Ribosomal RNA large subunit methyltransferase I HAMAP-Rule MF_01857
PRO_0000366275

Regions

Domain2 – 7978PUA

Sequences

Sequence LengthMass (Da)Tools
A7MZM6 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: E4C9A5DE8060B551

FASTA39744,430
        10         20         30         40         50         60 
MTAAIYLVKG REKSVKRKHP WIFSRGISKV EGEPALGETV DVFTHDGKWL AKAAYSPASQ 

        70         80         90        100        110        120 
IRARIWSFEK EEINKAFFVK RFNNAQLLRE DIIERDGLTG YRLIAAESDG MPGVTIDRYQ 

       130        140        150        160        170        180 
NFFVCQLLSA GAEYNKQAIV DALVECFPDC NVYERSDVAV RKKEGLKETT GVLHGEEPPK 

       190        200        210        220        230        240 
SVVIEENGVK ISVDIVGGHK TGFYLDQRDS RQQAMKYVKD KEVLNCFSYT GGFGLYALKG 

       250        260        270        280        290        300 
GAKRVINADV SQPALDTAKF NAELNEFDIS KKRAVFLNAD VFKLLREYRD QGTKFDVVIM 

       310        320        330        340        350        360 
DPPKFAESKA QLNGACRGYK DINMLAMQIL NPGGTLLTYS CSGLMDQVLF QKIIADAAVD 

       370        380        390 
ANRQVKFVER FEQAADHPTD TAYPEGFYLK GFACKVL

« Hide

References

[1]The Vibrio harveyi Genome Sequencing Project
Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000789 Genomic DNA. Translation: ABU71332.1.
RefSeqYP_001445559.1. NC_009783.1.

3D structure databases

ProteinModelPortalA7MZM6.
ModBaseSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_02370.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU71332; ABU71332; VIBHAR_02370.
GeneID5555862.
KEGGvha:VIBHAR_02370.
PATRIC20131458. VBIVibHar24526_2267.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1092.
HOGENOMHOG000266009.
KOK06969.
OMAQIRARIW.
ProtClustDBCLSK2484295.

Family and domain databases

HAMAPMF_01857. 23SrRNA_methyltr_I.
InterProIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023542. rRNA_lsu_MeTfrase_I.
IPR019614. SAM-dep_methyl-trfase.
[Graphical view]
PfamPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
PROSITEPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLMI_VIBHB
AccessionPrimary (citable) accession number: A7MZM6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 2, 2007
Last modified: May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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