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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei625ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCAM338187:G1HKJ-1388-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VIBHAR_01222
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000008152 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094631 – 862Leucine--tRNA ligaseAdd BLAST862

Proteomic databases

PRIDEiA7MY86

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_01222

Structurei

3D structure databases

ProteinModelPortaliA7MY86
SMRiA7MY86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi622 – 626"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A7MY86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEQYNPQDL EQKVQKHWDD NKTFVVSEDP NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WNREFATCTP EYYRWEQEFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKEIPQ WFIKITEYAQ
210 220 230 240 250
ELLDDLDKLE GWPEMVKTMQ RNWIGRSEGV ELRFALKDSE VKGQQDLEVY
260 270 280 290 300
TTRPDTLMGV TYVGIAAGHP LATIAAENNP ELAAFIEECK NTKVAEAELA
310 320 330 340 350
TMEKKGMATG LTAIHPLNGR EVPVYVANFV LMDYGTGAVM AVPAHDQRDF
360 370 380 390 400
EFATKYGLDI VPVIKPVDGS ELDTSEAAYT EKGVLFDSGE FDGLEFQAAF
410 420 430 440 450
DAIAAKLEAE GKGTKTVNFR LRDWGVSRQR YWGAPIPMVT TEDGEVHPVP
460 470 480 490 500
ADQLPVILPE DVVMDGVTSP IKADKEWAKT TFNGEPALRE TDTFDTFMES
510 520 530 540 550
SWYYARYCSP QADDILAPEK ANYWLPVDQY IGGIEHACMH LLYSRFFHKL
560 570 580 590 600
LRDAGYVTSD EPFKQLLCQG MVLADAFYFE NEKGGKEWVA PTDVAVERDG
610 620 630 640 650
KGRITSAKDT EGRDVTHSGM IKMSKSKNNG IDPQEMVDKY GADTVRLFMM
660 670 680 690 700
FASPADMTLE WQESGVEGAN RFLKRVWKLV NEHTSKGAAE AVDAAALSGD
710 720 730 740 750
QKALRRDVHK TIAKVTDDID RRQTFNTAIA AIMELMNKLA KAPQESAQDR
760 770 780 790 800
VILDEALKAV VAMLYPITPH ISYELWAALG EADIDNAAWP TFDEKALVED
810 820 830 840 850
EKTIVVQVNG KLRAKLTVAA DATKEQVEEL GLNDENVTKF TDGLTIRKVI
860
YVPGKLLNIV AN
Length:862
Mass (Da):97,056
Last modified:October 2, 2007 - v1
Checksum:i2C3CDC8621D78232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA Translation: ABU70211.1
RefSeqiWP_012127189.1, NC_022269.1

Genome annotation databases

EnsemblBacteriaiABU70211; ABU70211; VIBHAR_01222
GeneIDi5554910
KEGGivca:M892_06855
vha:VIBHAR_01222
PATRICifig|338187.25.peg.1407

Similar proteinsi

Entry informationi

Entry nameiSYL_VIBCB
AccessioniPrimary (citable) accession number: A7MY86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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