Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7MY86

- SYL_VIBCB

UniProt

A7MY86 - SYL_VIBCB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:VIBHAR_01222
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligasePRO_1000009463Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_01222.

Structurei

3D structure databases

ProteinModelPortaliA7MY86.
SMRiA7MY86. Positions 228-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi622 – 6265"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MY86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYNPQDL EQKVQKHWDD NKTFVVSEDP NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW
110 120 130 140 150
TYENIEYMKN QLKLLGFGYD WNREFATCTP EYYRWEQEFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKEIPQ WFIKITEYAQ
210 220 230 240 250
ELLDDLDKLE GWPEMVKTMQ RNWIGRSEGV ELRFALKDSE VKGQQDLEVY
260 270 280 290 300
TTRPDTLMGV TYVGIAAGHP LATIAAENNP ELAAFIEECK NTKVAEAELA
310 320 330 340 350
TMEKKGMATG LTAIHPLNGR EVPVYVANFV LMDYGTGAVM AVPAHDQRDF
360 370 380 390 400
EFATKYGLDI VPVIKPVDGS ELDTSEAAYT EKGVLFDSGE FDGLEFQAAF
410 420 430 440 450
DAIAAKLEAE GKGTKTVNFR LRDWGVSRQR YWGAPIPMVT TEDGEVHPVP
460 470 480 490 500
ADQLPVILPE DVVMDGVTSP IKADKEWAKT TFNGEPALRE TDTFDTFMES
510 520 530 540 550
SWYYARYCSP QADDILAPEK ANYWLPVDQY IGGIEHACMH LLYSRFFHKL
560 570 580 590 600
LRDAGYVTSD EPFKQLLCQG MVLADAFYFE NEKGGKEWVA PTDVAVERDG
610 620 630 640 650
KGRITSAKDT EGRDVTHSGM IKMSKSKNNG IDPQEMVDKY GADTVRLFMM
660 670 680 690 700
FASPADMTLE WQESGVEGAN RFLKRVWKLV NEHTSKGAAE AVDAAALSGD
710 720 730 740 750
QKALRRDVHK TIAKVTDDID RRQTFNTAIA AIMELMNKLA KAPQESAQDR
760 770 780 790 800
VILDEALKAV VAMLYPITPH ISYELWAALG EADIDNAAWP TFDEKALVED
810 820 830 840 850
EKTIVVQVNG KLRAKLTVAA DATKEQVEEL GLNDENVTKF TDGLTIRKVI
860
YVPGKLLNIV AN
Length:862
Mass (Da):97,056
Last modified:October 2, 2007 - v1
Checksum:i2C3CDC8621D78232
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU70211.1.
RefSeqiWP_012127189.1. NC_022269.1.
YP_001444438.1. NC_009783.1.
YP_008526138.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU70211; ABU70211; VIBHAR_01222.
GeneIDi16815541.
5554910.
KEGGivca:M892_06855.
vha:VIBHAR_01222.
PATRICi20129277. VBIVibHar24526_1199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU70211.1 .
RefSeqi WP_012127189.1. NC_022269.1.
YP_001444438.1. NC_009783.1.
YP_008526138.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MY86.
SMRi A7MY86. Positions 228-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_01222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU70211 ; ABU70211 ; VIBHAR_01222 .
GeneIDi 16815541.
5554910.
KEGGi vca:M892_06855.
vha:VIBHAR_01222.
PATRICi 20129277. VBIVibHar24526_1199.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-1213-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiSYL_VIBCB
AccessioniPrimary (citable) accession number: A7MY86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3