SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A7MY86

- SYL_VIBCB

UniProt

A7MY86 - SYL_VIBCB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, VIBHAR_01222
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:VIBHAR_01222
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_1000009463Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_01222.

Structurei

3D structure databases

ProteinModelPortaliA7MY86.
SMRiA7MY86. Positions 228-417.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MY86-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYNPQDL EQKVQKHWDD NKTFVVSEDP NKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVSRFQRLQG KNVMQPIGWD AFGLPAENAA VKNNTAPAPW 100
TYENIEYMKN QLKLLGFGYD WNREFATCTP EYYRWEQEFF TKLYEKGLVY 150
KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD TPVEQKEIPQ WFIKITEYAQ 200
ELLDDLDKLE GWPEMVKTMQ RNWIGRSEGV ELRFALKDSE VKGQQDLEVY 250
TTRPDTLMGV TYVGIAAGHP LATIAAENNP ELAAFIEECK NTKVAEAELA 300
TMEKKGMATG LTAIHPLNGR EVPVYVANFV LMDYGTGAVM AVPAHDQRDF 350
EFATKYGLDI VPVIKPVDGS ELDTSEAAYT EKGVLFDSGE FDGLEFQAAF 400
DAIAAKLEAE GKGTKTVNFR LRDWGVSRQR YWGAPIPMVT TEDGEVHPVP 450
ADQLPVILPE DVVMDGVTSP IKADKEWAKT TFNGEPALRE TDTFDTFMES 500
SWYYARYCSP QADDILAPEK ANYWLPVDQY IGGIEHACMH LLYSRFFHKL 550
LRDAGYVTSD EPFKQLLCQG MVLADAFYFE NEKGGKEWVA PTDVAVERDG 600
KGRITSAKDT EGRDVTHSGM IKMSKSKNNG IDPQEMVDKY GADTVRLFMM 650
FASPADMTLE WQESGVEGAN RFLKRVWKLV NEHTSKGAAE AVDAAALSGD 700
QKALRRDVHK TIAKVTDDID RRQTFNTAIA AIMELMNKLA KAPQESAQDR 750
VILDEALKAV VAMLYPITPH ISYELWAALG EADIDNAAWP TFDEKALVED 800
EKTIVVQVNG KLRAKLTVAA DATKEQVEEL GLNDENVTKF TDGLTIRKVI 850
YVPGKLLNIV AN 862
Length:862
Mass (Da):97,056
Last modified:October 2, 2007 - v1
Checksum:i2C3CDC8621D78232
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70211.1.
RefSeqiWP_012127189.1. NC_022269.1.
YP_001444438.1. NC_009783.1.
YP_008526138.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU70211; ABU70211; VIBHAR_01222.
GeneIDi16815541.
5554910.
KEGGivca:M892_06855.
vha:VIBHAR_01222.
PATRICi20129277. VBIVibHar24526_1199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU70211.1 .
RefSeqi WP_012127189.1. NC_022269.1.
YP_001444438.1. NC_009783.1.
YP_008526138.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MY86.
SMRi A7MY86. Positions 228-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_01222.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU70211 ; ABU70211 ; VIBHAR_01222 .
GeneIDi 16815541.
5554910.
KEGGi vca:M892_06855.
vha:VIBHAR_01222.
PATRICi 20129277. VBIVibHar24526_1199.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci VHAR338187:GJCH-1213-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiSYL_VIBCB
AccessioniPrimary (citable) accession number: A7MY86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi