A7MY69 (KDSA_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	VIBHAR_01254

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group › Vibrio harveyi

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP-Rule MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP-Rule MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00056
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP-Rule MF_00056		PRO_1000003351

Sequences

	Sequence		Length	Mass (Da)
	A7MY69 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 6464EAE8610FA32F	FASTA	283	30,746
	10 20 30 40 50 60 MEQKIVNIGD IQVANDKPFT LFAGMNVLES RDLAMQICEH YVKVTDKLGI PYVFKASFDK 70 80 90 100 110 120 ANRSSVHSYR GPGLEEGMKI FQELKDTFGV KIITDVHTEA QAQPVADVVD VIQLPAFLAR 130 140 150 160 170 180 QTDLVEAMAK TGAVINVKKP QFMSPGQVGN IVEKFAECGN ENIILCERGS CMGYDNLVVD 190 200 210 220 230 240 MLGFGVMKNA SKGSPIIFDV THSLQMRDPS GAASGGRREQ TVELAKAGLA TGIAGLFIEA 250 260 270 280 HPNPDQARCD GPSALPLDKL EPFLAQMKSL DDLIKSFADI DIK

References

[1]

The Vibrio harveyi Genome Sequencing Project Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000789 Genomic DNA. Translation: ABU70233.1.
RefSeq	YP_001444460.1. NC_009783.1.
3D structure databases
ProteinModelPortal	A7MY69.
SMR	A7MY69. Positions 1-281.
ModBase	Search...
Protein-protein interaction databases
STRING	338187.VIBHAR_01254.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU70233; ABU70233; VIBHAR_01254.
GeneID	5554491.
KEGG	vha:VIBHAR_01254.
PATRIC	20129338. VBIVibHar24526_1219.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HOG000023021.
KO	K01627.
OMA	LCDRGTC.
ProtClustDB	PRK05198.
Enzyme and pathway databases
UniPathway	UPA00030. UPA00357; UER00474.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00056. KDO8P_synth.
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
PANTHER	PTHR21057:SF2. PTHR21057:SF2. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_VIBHB

Accession

Primary (citable) accession number: A7MY69

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program