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A7MY25 (PUR5_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:VIBHAR_03200
OrganismVibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_1000046482

Sequences

Sequence LengthMass (Da)Tools
A7MY25 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 974E2E7322E40587

FASTA34636,878
        10         20         30         40         50         60 
MSGNNSSLSY KDAGVDIDAG NALVDRIKGA VKRTRRPEVM GGIGGFGALC ELPTKYKQPV 

        70         80         90        100        110        120 
LVSGTDGVGT KLRLALDMNK HDTIGVDLVA MCVNDLIVQG AEPLFFLDYY ATGKLDVDTA 

       130        140        150        160        170        180 
ADVVSGIADG CVQAGCALIG GETAEMPGMY EGEDYDVAGF CVGVVEKEDV IDGTKVAAGD 

       190        200        210        220        230        240 
ALIAVGSSGP HSNGYSLIRK ILEVSGADKN EELAGRTIGE HLLEPTKIYI KSALKMIEKH 

       250        260        270        280        290        300 
DIHAISHITG GGFWENIPRV LLEGTKAVID GNSWEWPIIF KWLQEKGNVE THEMYRTFNC 

       310        320        330        340 
GVGLVVALPK DQADAAVALL KEEGENAWVI GEIAQAEANE EQVEIQ

« Hide

References

[1]The Vibrio harveyi Genome Sequencing Project
Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K.
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000789 Genomic DNA. Translation: ABU72149.1.
RefSeqYP_001446376.1. NC_009783.1.

3D structure databases

ProteinModelPortalA7MY25.
SMRA7MY25. Positions 6-346.
ModBaseSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_03200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU72149; ABU72149; VIBHAR_03200.
GeneID5553383.
KEGGvha:VIBHAR_03200.
PATRIC20133041. VBIVibHar24526_3050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
HOGENOMHOG000229091.
KOK01933.
OMAIDMIAMN.
ProtClustDBPRK05385.

Enzyme and pathway databases

UniPathwayUPA00074; UER00129.

Family and domain databases

HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_VIBHB
AccessionPrimary (citable) accession number: A7MY25
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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