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A7MY02 (LPXB_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:VIBHAR_03224
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000049425

Sequences

Sequence LengthMass (Da)Tools
A7MY02 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: D6ED1C97B9F9F932

FASTA37942,782
        10         20         30         40         50         60 
MERPLRIGII AGELSGDTLG EGFIKAVKQQ YPDAEFVGIG GPKMIAQGCE SLFDMEELAV 

        70         80         90        100        110        120 
MGLVEVLGRL PRLLKVKAQL VKYFTENPPD VFIGIDAPDF NLRVELDLKN AGIKTVHYVS 

       130        140        150        160        170        180 
PSVWAWRQKR IFKIEAATNL VLAFLPFEKA FYDKFNVPCE FIGHTLADAI PLQSDKASAR 

       190        200        210        220        230        240 
EILGLEQDKQ WLSVLPGSRG SELKMLSQPF IETCKKLHQK FPDIGFVVAL VNQKRREQFE 

       250        260        270        280        290        300 
QAWKEHAPEL DFKLVDDTAR NVITASDAVM LASGTVALEC MLLKRPMVVG YRVNAVTAFL 

       310        320        330        340        350        360 
AKRLLKTKYV SLPNILADTE LVKEYLQDDC TPDNLFDEVS RLLESDNREM LDKFTEMHHW 

       370 
IRKDADQQAA NAVLKLIEK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000789 Genomic DNA. Translation: ABU72173.1.
RefSeqYP_001446400.1. NC_009783.1.
YP_008527657.1. NC_022269.1.

3D structure databases

ProteinModelPortalA7MY02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_03224.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU72173; ABU72173; VIBHAR_03224.
GeneID16817155.
5554154.
KEGGvca:M892_14955.
vha:VIBHAR_03224.
PATRIC20133083. VBIVibHar24526_3071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-3214-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_VIBCB
AccessionPrimary (citable) accession number: A7MY02
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways