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A7MY02

- LPXB_VIBCB

UniProt

A7MY02 - LPXB_VIBCB

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, VIBHAR_03224
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-3214-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:VIBHAR_03224
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000049425Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_03224.

Structurei

3D structure databases

ProteinModelPortaliA7MY02.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MY02-1 [UniParc]FASTAAdd to Basket

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MERPLRIGII AGELSGDTLG EGFIKAVKQQ YPDAEFVGIG GPKMIAQGCE    50
SLFDMEELAV MGLVEVLGRL PRLLKVKAQL VKYFTENPPD VFIGIDAPDF 100
NLRVELDLKN AGIKTVHYVS PSVWAWRQKR IFKIEAATNL VLAFLPFEKA 150
FYDKFNVPCE FIGHTLADAI PLQSDKASAR EILGLEQDKQ WLSVLPGSRG 200
SELKMLSQPF IETCKKLHQK FPDIGFVVAL VNQKRREQFE QAWKEHAPEL 250
DFKLVDDTAR NVITASDAVM LASGTVALEC MLLKRPMVVG YRVNAVTAFL 300
AKRLLKTKYV SLPNILADTE LVKEYLQDDC TPDNLFDEVS RLLESDNREM 350
LDKFTEMHHW IRKDADQQAA NAVLKLIEK 379
Length:379
Mass (Da):42,782
Last modified:October 2, 2007 - v1
Checksum:iD6ED1C97B9F9F932
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU72173.1.
RefSeqiWP_012128689.1. NC_022269.1.
YP_001446400.1. NC_009783.1.
YP_008527657.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU72173; ABU72173; VIBHAR_03224.
GeneIDi16817155.
5554154.
KEGGivca:M892_14955.
vha:VIBHAR_03224.
PATRICi20133083. VBIVibHar24526_3071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU72173.1 .
RefSeqi WP_012128689.1. NC_022269.1.
YP_001446400.1. NC_009783.1.
YP_008527657.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MY02.
ModBasei Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_03224.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU72173 ; ABU72173 ; VIBHAR_03224 .
GeneIDi 16817155.
5554154.
KEGGi vca:M892_14955.
vha:VIBHAR_03224.
PATRICi 20133083. VBIVibHar24526_3071.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci VHAR338187:GJCH-3214-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiLPXB_VIBCB
AccessioniPrimary (citable) accession number: A7MY02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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