A7MY02 (LPXB_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	VIBHAR_03224

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio harveyi group › Vibrio harveyi

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_1000049425

Sequences

	Sequence		Length	Mass (Da)
	A7MY02 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: D6ED1C97B9F9F932	FASTA	379	42,782
	10 20 30 40 50 60 MERPLRIGII AGELSGDTLG EGFIKAVKQQ YPDAEFVGIG GPKMIAQGCE SLFDMEELAV 70 80 90 100 110 120 MGLVEVLGRL PRLLKVKAQL VKYFTENPPD VFIGIDAPDF NLRVELDLKN AGIKTVHYVS 130 140 150 160 170 180 PSVWAWRQKR IFKIEAATNL VLAFLPFEKA FYDKFNVPCE FIGHTLADAI PLQSDKASAR 190 200 210 220 230 240 EILGLEQDKQ WLSVLPGSRG SELKMLSQPF IETCKKLHQK FPDIGFVVAL VNQKRREQFE 250 260 270 280 290 300 QAWKEHAPEL DFKLVDDTAR NVITASDAVM LASGTVALEC MLLKRPMVVG YRVNAVTAFL 310 320 330 340 350 360 AKRLLKTKYV SLPNILADTE LVKEYLQDDC TPDNLFDEVS RLLESDNREM LDKFTEMHHW 370 IRKDADQQAA NAVLKLIEK

References

[1]

The Vibrio harveyi Genome Sequencing Project Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000789 Genomic DNA. Translation: ABU72173.1.
RefSeq	YP_001446400.1. NC_009783.1.
3D structure databases
ProteinModelPortal	A7MY02.
ModBase	Search...
Protein-protein interaction databases
STRING	338187.VIBHAR_03224.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABU72173; ABU72173; VIBHAR_03224.
GeneID	5554154.
KEGG	vha:VIBHAR_03224.
PATRIC	20133083. VBIVibHar24526_3071.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HOG000018003.
KO	K00748.
OMA	PTVWAWR.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	VHAR338187:GJCH-3214-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB.
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_VIBHB

Accession

Primary (citable) accession number: A7MY02

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	May 29, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program