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A7MXT2 (GPPA_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VIBHAR_00339
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000314501

Sequences

Sequence LengthMass (Da)Tools
A7MXT2 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 5C50888DBAB586EF

FASTA49754,724
        10         20         30         40         50         60 
MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE HNSLSMEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPKQN IRIVGTATLR TATNVDVFLE KANQILGQPI EVITGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGSGRRLVVD IGGASTELII GEGFEAKALT SLKMGCVTWL ENFFKDRQLN 

       190        200        210        220        230        240 
ARNFDAAIEG AKQTLMPILG QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR 

       250        260        270        280        290        300 
LQKQAMLADH LEELDIEGLT LERALVFPSG LSILIAIFEQ LEIDAMTLAG GALREGLVYE 

       310        320        330        340        350        360 
MVDELRQNDI RARTIRSVQN RYQLDCQYGE QVAKLAGKLL EQVGGEAWVA EPQGKVLLKT 

       370        380        390        400        410        420 
TAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKFFI GEIARRYREQ LTSLPEQHAL 

       430        440        450        460        470        480 
SGTSGKRVLR LLRLAVLLSH RRNPDLEPCV TLTAEGDKLT LSIDAKWLEA NPLTAAELEI 

       490 
ESNRQTDIGW PLSIVTC 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000789 Genomic DNA. Translation: ABU69361.1.
RefSeqYP_001443588.1. NC_009783.1.
YP_008526939.1. NC_022269.1.

3D structure databases

ProteinModelPortalA7MXT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_00339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU69361; ABU69361; VIBHAR_00339.
GeneID16816369.
5555860.
KEGGvha:VIBHAR_00339.
PATRIC20127563. VBIVibHar24526_0371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-332-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBCB
AccessionPrimary (citable) accession number: A7MXT2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways