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A7MXT2

- GPPA_VIBCB

UniProt

A7MXT2 - GPPA_VIBCB

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-332-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VIBHAR_00339
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_00339.

Structurei

3D structure databases

ProteinModelPortaliA7MXT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MXT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE
60 70 80 90 100
HNSLSMEAMQ RGWDCLSLFA ERLQDIPKQN IRIVGTATLR TATNVDVFLE
110 120 130 140 150
KANQILGQPI EVITGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAKALT SLKMGCVTWL ENFFKDRQLN ARNFDAAIEG AKQTLMPILG
210 220 230 240 250
QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR LQKQAMLADH
260 270 280 290 300
LEELDIEGLT LERALVFPSG LSILIAIFEQ LEIDAMTLAG GALREGLVYE
310 320 330 340 350
MVDELRQNDI RARTIRSVQN RYQLDCQYGE QVAKLAGKLL EQVGGEAWVA
360 370 380 390 400
EPQGKVLLKT TAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKFFI
410 420 430 440 450
GEIARRYREQ LTSLPEQHAL SGTSGKRVLR LLRLAVLLSH RRNPDLEPCV
460 470 480 490
TLTAEGDKLT LSIDAKWLEA NPLTAAELEI ESNRQTDIGW PLSIVTC
Length:497
Mass (Da):54,724
Last modified:October 2, 2007 - v1
Checksum:i5C50888DBAB586EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU69361.1.
RefSeqiYP_001443588.1. NC_009783.1.
YP_008526939.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU69361; ABU69361; VIBHAR_00339.
GeneIDi16816369.
5555860.
KEGGivca:M892_11020.
vha:VIBHAR_00339.
PATRICi20127563. VBIVibHar24526_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU69361.1 .
RefSeqi YP_001443588.1. NC_009783.1.
YP_008526939.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MXT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_00339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU69361 ; ABU69361 ; VIBHAR_00339 .
GeneIDi 16816369.
5555860.
KEGGi vca:M892_11020.
vha:VIBHAR_00339.
PATRICi 20127563. VBIVibHar24526_0371.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VHAR338187:GJCH-332-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiGPPA_VIBCB
AccessioniPrimary (citable) accession number: A7MXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3