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A7MXT2

- GPPA_VIBCB

UniProt

A7MXT2 - GPPA_VIBCB

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, VIBHAR_00339
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-332-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:VIBHAR_00339
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_0000314501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_00339.

Structurei

3D structure databases

ProteinModelPortaliA7MXT2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MXT2-1 [UniParc]FASTAAdd to Basket

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MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
HNSLSMEAMQ RGWDCLSLFA ERLQDIPKQN IRIVGTATLR TATNVDVFLE 100
KANQILGQPI EVITGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII 150
GEGFEAKALT SLKMGCVTWL ENFFKDRQLN ARNFDAAIEG AKQTLMPILG 200
QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR LQKQAMLADH 250
LEELDIEGLT LERALVFPSG LSILIAIFEQ LEIDAMTLAG GALREGLVYE 300
MVDELRQNDI RARTIRSVQN RYQLDCQYGE QVAKLAGKLL EQVGGEAWVA 350
EPQGKVLLKT TAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKFFI 400
GEIARRYREQ LTSLPEQHAL SGTSGKRVLR LLRLAVLLSH RRNPDLEPCV 450
TLTAEGDKLT LSIDAKWLEA NPLTAAELEI ESNRQTDIGW PLSIVTC 497
Length:497
Mass (Da):54,724
Last modified:October 2, 2007 - v1
Checksum:i5C50888DBAB586EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU69361.1.
RefSeqiYP_001443588.1. NC_009783.1.
YP_008526939.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU69361; ABU69361; VIBHAR_00339.
GeneIDi16816369.
5555860.
KEGGivca:M892_11020.
vha:VIBHAR_00339.
PATRICi20127563. VBIVibHar24526_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU69361.1 .
RefSeqi YP_001443588.1. NC_009783.1.
YP_008526939.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MXT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_00339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU69361 ; ABU69361 ; VIBHAR_00339 .
GeneIDi 16816369.
5555860.
KEGGi vca:M892_11020.
vha:VIBHAR_00339.
PATRICi 20127563. VBIVibHar24526_0371.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VHAR338187:GJCH-332-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiGPPA_VIBCB
AccessioniPrimary (citable) accession number: A7MXT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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