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A7MXT2

- GPPA_VIBCB

UniProt

A7MXT2 - GPPA_VIBCB

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-332-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VIBHAR_00339
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000314501Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_00339.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MXT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MXT2-1 [UniParc]FASTAAdd to Basket

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    MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
    HNSLSMEAMQ RGWDCLSLFA ERLQDIPKQN IRIVGTATLR TATNVDVFLE 100
    KANQILGQPI EVITGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII 150
    GEGFEAKALT SLKMGCVTWL ENFFKDRQLN ARNFDAAIEG AKQTLMPILG 200
    QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR LQKQAMLADH 250
    LEELDIEGLT LERALVFPSG LSILIAIFEQ LEIDAMTLAG GALREGLVYE 300
    MVDELRQNDI RARTIRSVQN RYQLDCQYGE QVAKLAGKLL EQVGGEAWVA 350
    EPQGKVLLKT TAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKFFI 400
    GEIARRYREQ LTSLPEQHAL SGTSGKRVLR LLRLAVLLSH RRNPDLEPCV 450
    TLTAEGDKLT LSIDAKWLEA NPLTAAELEI ESNRQTDIGW PLSIVTC 497
    Length:497
    Mass (Da):54,724
    Last modified:October 2, 2007 - v1
    Checksum:i5C50888DBAB586EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU69361.1.
    RefSeqiYP_001443588.1. NC_009783.1.
    YP_008526939.1. NC_022269.1.

    Genome annotation databases

    EnsemblBacteriaiABU69361; ABU69361; VIBHAR_00339.
    GeneIDi16816369.
    5555860.
    KEGGivca:M892_11020.
    vha:VIBHAR_00339.
    PATRICi20127563. VBIVibHar24526_0371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU69361.1 .
    RefSeqi YP_001443588.1. NC_009783.1.
    YP_008526939.1. NC_022269.1.

    3D structure databases

    ProteinModelPortali A7MXT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_00339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU69361 ; ABU69361 ; VIBHAR_00339 .
    GeneIDi 16816369.
    5555860.
    KEGGi vca:M892_11020.
    vha:VIBHAR_00339.
    PATRICi 20127563. VBIVibHar24526_0371.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci VHAR338187:GJCH-332-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiGPPA_VIBCB
    AccessioniPrimary (citable) accession number: A7MXT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3