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A7MWW3 (NADK_VIBCB) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:VIBHAR_01131
OrganismVibrio campbellii (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]
Taxonomic identifier338187 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294NAD kinase HAMAP-Rule MF_00361
PRO_1000079528

Regions

Nucleotide binding74 – 752NAD By similarity
Nucleotide binding148 – 1492NAD By similarity
Nucleotide binding189 – 1946NAD By similarity

Sites

Active site741Proton acceptor By similarity
Binding site1591NAD By similarity
Binding site1761NAD By similarity
Binding site1781NAD By similarity
Binding site2491NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A7MWW3 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: C93D629951D59202

FASTA29432,381
        10         20         30         40         50         60 
MKNPCNVIAI IGKPRDQQAI QTHRELYEWL TSEGYQVFID DRLAAILDEI PQSQFASLVE 

        70         80         90        100        110        120 
LGKNADLAIV VGGDGNMLGA ARILSRFDVA VIGVNRGNLG FLTDLNPDDF KEALKAVLKG 

       130        140        150        160        170        180 
KYIEEERFLL EAEIHRHGQI KSHNAALNEA VLHPGQVAHM IEFEVYIDDS FAFSLRADGL 

       190        200        210        220        230        240 
IVSTPTGSTA YSLSGGGPIL SPSLNAISLV PMFPHTLSSR PLVVDGKRRI KLIVSPENRG 

       250        260        270        280        290 
TQEVSCDGQV SLPVSPGDEI HIYQSPNVLK LIHPKDYSYY HVLRNKLGWS SKLF 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000789 Genomic DNA. Translation: ABU70121.1.
RefSeqYP_001444348.1. NC_009783.1.
YP_008526223.1. NC_022269.1.

3D structure databases

ProteinModelPortalA7MWW3.
SMRA7MWW3. Positions 6-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338187.VIBHAR_01131.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU70121; ABU70121; VIBHAR_01131.
GeneID16815626.
5553668.
KEGGvca:M892_07285.
vha:VIBHAR_01131.
PATRIC20129101. VBIVibHar24526_1111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227221.
KOK00858.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycVHAR338187:GJCH-1122-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_VIBCB
AccessionPrimary (citable) accession number: A7MWW3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families