Reviewed, UniProtKB/Swiss-Prot A7MWS7 (MTLD_VIBHB)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	VIBHAR_00833

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000011819
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7MWS7-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 32FCE377874D05A1	FASTA	382	41,931
	10 20 30 40 50 60 MKNAVHFGAG NIGRGFIGKL LADAEVEVTF ADVDAPLVDQ LSHKQEYKVK VVGTECQIDT 70 80 90 100 110 120 VTHVTAVNSA SEDVIDRIVK TDLVTTAVGP NVLDIIAKTI ATGIAKRFAA GNDKPLNIIA 130 140 150 160 170 180 CENMVRGTTH LKGEVYKHLD ESLHSKADEL VGFVDSAVDR IVPPAEAAND DPLEVTVESF 190 200 210 220 230 240 SEWIVDEQQF KGEIPDIAGM EKTNNLMAFV ERKLFTLNTG HCITAYLGCL KGHRTIREAI 250 260 270 280 290 300 EDPSIHAEVK QAMQESGEVL IKRYGFDRDM HNAYIEKILG RFANPYLVDE VDRVGRQPIR 310 320 330 340 350 360 KLGANDRLVK PLLGTIEYGT ENKTLLKGIA AALKYTNDTD PQAVEQQNSL KEVGVKKTLA 370 380 TYTGLAENSA EVTQIETLYN QL

References

[1]

Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000789 Genomic DNA. Translation: ABU69834.1.
RefSeq	YP_001444061.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5554335.
GenomeReviews	Gene locus VIBHAR_00833 in contig CP000789_GR.
KEGG	vha:VIBHAR_00833.
NMPDR	fig|338187.4.peg.657.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_VIBHB

Accession

Primary (citable) accession number: A7MWS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)