A7MVN0 (PUR7_VIBHB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	VIBHAR_02039

Organism

Vibrio harveyi (strain ATCC BAA-1116 / BB120) [Complete proteome] [HAMAP]

Taxonomic identifier

338187 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000117862

Sequences

	Sequence		Length	Mass (Da)
	A7MVN0 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 3835F075FE8296A5	FASTA	367	41,074
	10 20 30 40 50 60 MSLANQVLAV NDDLPIRTHK PVHSGKVRSV YWLTEEDSAR LIKEKGYDVA PDAPLAIMVI 70 80 90 100 110 120 SDRISAFDCI WHGEGGLKGV PGKGAALNAI SNHWFKLFKD NGLADSHILD IPHPFVWIVQ 130 140 150 160 170 180 KAKPVKIEAI CRKYITGSMW RAYANGEREF CGIELPEGLE KDKALPELLM TPSTKGILKG 190 200 210 220 230 240 IPGVPEADDV NITRQNIVDN FEAFNFSNAK DIAQYEKLLK EGFNVISSAL EAIDQTFVDT 250 260 270 280 290 300 KFEFGYVHDA AGNEKLIYMD EVGTPDSSRI WDTKEYQAGN IVENSKEGFR QFLLSHFPDP 310 320 330 340 350 360 DILLNKERMP EREALARDNE LPVESLMDIS RTYIGIAEKI TGQPIKLSND PKAEIIEILS KEYGLID

References

[1]

The Vibrio harveyi Genome Sequencing Project Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C., Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J., Wilson R.K. Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1116 / BB120.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000789 Genomic DNA. Translation: ABU71004.1.
RefSeq	YP_001445231.1. NC_009783.1.
3D structure databases
ProteinModelPortal	A7MVN0.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MVN0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5552919.
GenomeReviews	Gene locus VIBHAR_02039 in contig CP000789_GR.
KEGG	vha:VIBHAR_02039.
NMPDR	fig|338187.4.peg.1519.
PATRIC	20130832. VBIVibHar24526_1957.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_VIBHB

Accession

Primary (citable) accession number: A7MVN0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program