ID   DNAE2_VIBHB             Reviewed;        1024 AA.
AC   A7MUN4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 14.
DE   RecName: Full=Error-prone DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=dnaE2; OrderedLocusNames=VIBHAR_02868;
OS   Vibrio harveyi (strain ATCC BAA-1116 / BB120).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=338187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N.,
RA   Pepin K., Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C.,
RA   Irgon J., Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase (By similarity).
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000789; ABU71821.1; -; Genomic_DNA.
DR   RefSeq; YP_001446048.1; -.
DR   GeneID; 5554099; -.
DR   GenomeReviews; CP000789_GR; VIBHAR_02868.
DR   KEGG; vha:VIBHAR_02868; -.
DR   NMPDR; fig|338187.4.peg.2076; -.
DR   OMA; A7MUN4; MGFYSPD.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045020; P:error-prone DNA repair; IEA:HAMAP.
DR   HAMAP; MF_01902; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR004365; NA_bd_OB_tRNA-helicase.
DR   InterPro; IPR004013; PHP_C.
DR   InterPro; IPR003141; PHP_N.
DR   InterPro; IPR004805; PolC_alpha.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication;
KW   DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.
FT   CHAIN         1   1024       Error-prone DNA polymerase.
FT                                /FTId=PRO_1000073692.
SQ   SEQUENCE   1024 AA;  116906 MW;  A9755E574212949F CRC64;
     MSYAELFCQS NFSFLTGASH AEELVLQAAF YRYQAIAITD ECSVAGVVKA HATIEQHKLD
     IKQIVGSMFW LNDECQVVLL CPCRKAYAEL CRIITNARRR SEKGSYQLSE WDLMSVRHCF
     VLWLPTHQES DHYWGRWLQQ HHAHRLWVAI QRHLGGDDDA YTTHCELLAN EFQLPIAACG
     GVLMHAVERL PLQHVLTAVK HGCSVDKLGF SRLSNAERAL RPLNKLSRIY KSKWLEESTH
     IADLCEFKLS DLKYEYPTEL IPNGYTPTSY LRMLVERGKK LRFPEGIPAD IHQTIENELA
     LIEELEYHYY FLTIHDIVMF AKQQGILYQG RGSAANSVVC YCLEITAVDP RQISVLFERF
     ISREREEPPD IDVDFEHERR EEVIQYIYKK YGRERAALAA TVISYRFKSA VREVGKALGI
     EETQLDFFIK NVNRRDRTQG WQAQIIELGL QPESLKGQQF IQLVNEITGF PRHLSQHVGG
     FVISSGPLYE LVPVENASME DRTIIQWDKD DLESLKLLKV DVLALGMLNA IRKCFQLVEK
     HHQRSLSIAE ITRLQDDPHV YRMIQKADTV GVFQIESRAQ MSMLPRLKPA RYYDLVVQIA
     IARPGPIQGD MVHPFLKRRN GEEPISYPSE EVKSVLERTM GVPIFQEQVI KLAMVAAGFS
     GGEADQLRRA MAAWKKNGDL AKFKPKLIDG MRERGYDLEF AERIFDQICG FGEYGFPESH
     SASFAVLAYC SAWLKFYYPA EFYTALLNSQ PMGFYSPSQL IQDARRHGVE VLPVCINHSS
     YQHHLVQRPN GRLGVQLGFR LVKGFNQESA SRLVERRPST GYRAIQEVKQ ILRNRRDIEL
     LASADAFQIL SGNRYNARWA AMDSLSDLPL FNHIEEPMAN YQAQPSEYEN LIEDYASTGL
     SLSRHPITLL EEAGKLPRFT RMKQLVEKEH NSLVTVIGVV TGRQSPGTAA GVTFFTLEDD
     TGNINVVVWR ATARAQKQAY LTSKVLMVKG ILEREGEVTH VIAGKLIDCT HNLAELKSKS
     RDFH
//