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A7MU31

- EX7L_VIBCB

UniProt

A7MU31 - EX7L_VIBCB

Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

    Catalytic activityi

    Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

    GO - Molecular functioni

    1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
    2. nucleic acid binding Source: InterPro

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Enzyme and pathway databases

    BioCyciVHAR338187:GJCH-1066-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
    Alternative name(s):
    Exodeoxyribonuclease VII large subunitUniRule annotation
    Short name:
    Exonuclease VII large subunitUniRule annotation
    Gene namesi
    Name:xseAUniRule annotation
    Ordered Locus Names:VIBHAR_01075
    OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
    Taxonomic identifieri338187 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000008152: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exodeoxyribonuclease VII complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Exodeoxyribonuclease 7 large subunitPRO_1000048791Add
    BLAST

    Interactioni

    Subunit structurei

    Heterooligomer composed of large and small subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi338187.VIBHAR_01075.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the XseA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1570.
    HOGENOMiHOG000229265.
    KOiK03601.
    OrthoDBiEOG64R65J.

    Family and domain databases

    HAMAPiMF_00378. Exonuc_7_L.
    InterProiIPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view]
    PfamiPF02601. Exonuc_VII_L. 1 hit.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00237. xseA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7MU31-1 [UniParc]FASTAAdd to Basket

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    MLSQTNQNIF TVSRLNAEVR LLLENEMGIV WLVGEISNFS APVSGHWYLT    50
    LKDSRAQVKC AMFRGNNRRV TFKPANGNQV LVKARLSLYE PRGDYQLIIE 100
    SMQPEGDGRL QQEFEALKMK LAAEGLFAQT NKQPLPEHPK RVGVITSKTG 150
    AALYDILDVL KRRDPSLPVV VYPTMVQGEE AAIQMAQAIG RANSRDECDV 200
    LIVGRGGGSL EDLWCFNNEI LARTIAASQI PIISAVGHEV DVTIADFVAD 250
    IRAPTPSAAA ELVSRDNSHK DQALVTHQHK LASAMRYYLA QQKQQSAQLM 300
    HRLERQHPSY QLQRQTQQLD ELEMRLQRAM QRFITTRQQA VERKHHRLQL 350
    NSPVKRLAEQ KSKLDRVEQK LLDAMDRKLL TMRHQLAIAA EKLDTVSPLA 400
    TLKRGYSITQ TEQGQVVTQA KDVKTGDVLV TRLSDGELRS TVN 443
    Length:443
    Mass (Da):49,854
    Last modified:October 2, 2007 - v1
    Checksum:i38CA4E6116D1F298
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU70068.1.
    RefSeqiYP_001444295.1. NC_009783.1.
    YP_008526275.1. NC_022269.1.

    Genome annotation databases

    EnsemblBacteriaiABU70068; ABU70068; VIBHAR_01075.
    GeneIDi16815678.
    5555978.
    KEGGivca:M892_07545.
    vha:VIBHAR_01075.
    PATRICi20128994. VBIVibHar24526_1058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000789 Genomic DNA. Translation: ABU70068.1 .
    RefSeqi YP_001444295.1. NC_009783.1.
    YP_008526275.1. NC_022269.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338187.VIBHAR_01075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU70068 ; ABU70068 ; VIBHAR_01075 .
    GeneIDi 16815678.
    5555978.
    KEGGi vca:M892_07545.
    vha:VIBHAR_01075.
    PATRICi 20128994. VBIVibHar24526_1058.

    Phylogenomic databases

    eggNOGi COG1570.
    HOGENOMi HOG000229265.
    KOi K03601.
    OrthoDBi EOG64R65J.

    Enzyme and pathway databases

    BioCyci VHAR338187:GJCH-1066-MONOMER.

    Family and domain databases

    HAMAPi MF_00378. Exonuc_7_L.
    InterProi IPR003753. Exonuc_VII_L.
    IPR020579. Exonuc_VII_lsu_C.
    IPR025824. OB-fold_nuc-bd_dom.
    [Graphical view ]
    Pfami PF02601. Exonuc_VII_L. 1 hit.
    PF13742. tRNA_anti_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00237. xseA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1116 / BB120.

    Entry informationi

    Entry nameiEX7L_VIBCB
    AccessioniPrimary (citable) accession number: A7MU31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3