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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1066-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:VIBHAR_01075
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Exodeoxyribonuclease 7 large subunitPRO_1000048791Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_01075.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1570.
HOGENOMiHOG000229265.
KOiK03601.
OMAiRFTQLFH.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MU31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSQTNQNIF TVSRLNAEVR LLLENEMGIV WLVGEISNFS APVSGHWYLT
60 70 80 90 100
LKDSRAQVKC AMFRGNNRRV TFKPANGNQV LVKARLSLYE PRGDYQLIIE
110 120 130 140 150
SMQPEGDGRL QQEFEALKMK LAAEGLFAQT NKQPLPEHPK RVGVITSKTG
160 170 180 190 200
AALYDILDVL KRRDPSLPVV VYPTMVQGEE AAIQMAQAIG RANSRDECDV
210 220 230 240 250
LIVGRGGGSL EDLWCFNNEI LARTIAASQI PIISAVGHEV DVTIADFVAD
260 270 280 290 300
IRAPTPSAAA ELVSRDNSHK DQALVTHQHK LASAMRYYLA QQKQQSAQLM
310 320 330 340 350
HRLERQHPSY QLQRQTQQLD ELEMRLQRAM QRFITTRQQA VERKHHRLQL
360 370 380 390 400
NSPVKRLAEQ KSKLDRVEQK LLDAMDRKLL TMRHQLAIAA EKLDTVSPLA
410 420 430 440
TLKRGYSITQ TEQGQVVTQA KDVKTGDVLV TRLSDGELRS TVN
Length:443
Mass (Da):49,854
Last modified:October 2, 2007 - v1
Checksum:i38CA4E6116D1F298
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU70068.1.
RefSeqiWP_012127095.1. NC_022269.1.
YP_008526275.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU70068; ABU70068; VIBHAR_01075.
KEGGivca:M892_07545.
vha:VIBHAR_01075.
PATRICi20128994. VBIVibHar24526_1058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU70068.1.
RefSeqiWP_012127095.1. NC_022269.1.
YP_008526275.1. NC_022269.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi338187.VIBHAR_01075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU70068; ABU70068; VIBHAR_01075.
KEGGivca:M892_07545.
vha:VIBHAR_01075.
PATRICi20128994. VBIVibHar24526_1058.

Phylogenomic databases

eggNOGiCOG1570.
HOGENOMiHOG000229265.
KOiK03601.
OMAiRFTQLFH.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-1066-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiEX7L_VIBCB
AccessioniPrimary (citable) accession number: A7MU31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 27, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.