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A7MTN8

- TRMB_VIBCB

UniProt

A7MTN8 - TRMB_VIBCB

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, VIBHAR_03590
Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681S-adenosyl-L-methionine By similarity
Binding sitei93 – 931S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine By similarity
Active sitei143 – 1431 By similarity
Binding sitei143 – 1431S-adenosyl-L-methionine By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei180 – 1801Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVHAR338187:GJCH-3580-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:VIBHAR_03590
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000008152: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_1000064415Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338187.VIBHAR_03590.

Structurei

3D structure databases

ProteinModelPortaliA7MTN8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni217 – 2204Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MTN8-1 [UniParc]FASTAAdd to Basket

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MSEVTTNEYN EDGKMIRKIR SFVRREGRLT KGQENAMNEC WPTMGIDYKA    50
ELLDWKEVFG NDNPVVLEIG FGMGASLVEM AKNAPEKNFI GIEVHSPGVG 100
ACLADAREAG ITNLRVMCHD AVEVFEHMIP NGSLATLQLF FPDPWHKKRH 150
HKRRIVQLEF AEMVRQKLIL NEGIFHMATD WENYAEHMIE IMNQAPGFDN 200
IAEEGDFIPR PEERPLTKFE ARGHRLGHGV WDIKFKRTA 239
Length:239
Mass (Da):27,434
Last modified:October 2, 2007 - v1
Checksum:i7B63A5B25019EBD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU72525.1.
RefSeqiWP_012128949.1. NC_022269.1.
YP_001446752.1. NC_009783.1.
YP_008527312.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU72525; ABU72525; VIBHAR_03590.
GeneIDi16816799.
5553843.
KEGGivca:M892_13175.
vha:VIBHAR_03590.
PATRICi20133793. VBIVibHar24526_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000789 Genomic DNA. Translation: ABU72525.1 .
RefSeqi WP_012128949.1. NC_022269.1.
YP_001446752.1. NC_009783.1.
YP_008527312.1. NC_022269.1.

3D structure databases

ProteinModelPortali A7MTN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338187.VIBHAR_03590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU72525 ; ABU72525 ; VIBHAR_03590 .
GeneIDi 16816799.
5553843.
KEGGi vca:M892_13175.
vha:VIBHAR_03590.
PATRICi 20133793. VBIVibHar24526_3414.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci VHAR338187:GJCH-3580-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1116 / BB120.

Entry informationi

Entry nameiTRMB_VIBCB
AccessioniPrimary (citable) accession number: A7MTN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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