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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1

Gene

accD1

Organism
Vibrio campbellii (strain ATCC BAA-1116 / BB120)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 2 (accD2), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1 (accD1)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ZincUniRule annotation1
Metal bindingi32ZincUniRule annotation1
Metal bindingi48ZincUniRule annotation1
Metal bindingi51ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeUniRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1UniRule annotation (EC:6.4.1.2UniRule annotation)
Short name:
ACCase subunit beta 1UniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta 1UniRule annotation
Gene namesi
Name:accD1UniRule annotation
Ordered Locus Names:VIBHAR_03100
OrganismiVibrio campbellii (strain ATCC BAA-1116 / BB120)
Taxonomic identifieri338187 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000008152 Componenti: Chromosome I

Subcellular locationi

A7MS74:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003590881 – 308Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1Add BLAST308

Proteomic databases

PRIDEiA7MS74.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi338187.VIBHAR_03100.

Structurei

3D structure databases

ProteinModelPortaliA7MS74.
SMRiA7MS74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 294CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST270

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 51C4-typeUniRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG4107QTG. Bacteria.
COG0777. LUCA.
HOGENOMiHOG000021670.
KOiK01963.
OMAiPEGLWIK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MS74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWLEKILEK SNLVSSRKAS IPEGVWTKCT SCEQVLYHAE LERNLEVCPK
60 70 80 90 100
CNHHMRMKAR RRLETFLDEG ERVELGTELE PQDKLKFKDS KRYKERISAA
110 120 130 140 150
QKSSGEKDAL IVMQGELLGM PLVACAFEFS FMGGSMGSVV GARFVKAVEA
160 170 180 190 200
AIENNCALVC FSASGGARMQ EALMSLMQMA KTSAALERLS DKGLPFISVL
210 220 230 240 250
TDPTMGGVSA SLAMLGDINI GEPKALIGFA GRRVIEQTVR EDLPEGFQRS
260 270 280 290 300
EFLLEHGAID MIVDRREMRQ RVGGLVAKLT NHKSPMVVSV NESPNEEPYS

VPEADEKG
Length:308
Mass (Da):33,989
Last modified:October 2, 2007 - v1
Checksum:iBFDF52F44373D502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000789 Genomic DNA. Translation: ABU72049.1.
RefSeqiWP_005439795.1. NC_022269.1.

Genome annotation databases

EnsemblBacteriaiABU72049; ABU72049; VIBHAR_03100.
GeneIDi5555973.
KEGGivca:M892_15555.
vha:VIBHAR_03100.
PATRICifig|338187.25.peg.3089.

Similar proteinsi

Entry informationi

Entry nameiACCD1_VIBCB
AccessioniPrimary (citable) accession number: A7MS74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 2, 2007
Last modified: October 25, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families