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A7MR85

- GCSP_CROS8

UniProt

A7MR85 - GCSP_CROS8

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-422-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:ESA_00426
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_1000045583Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi290339.ESA_00426.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MR85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7MR85-1 [UniParc]FASTAAdd to Basket

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    MTQTLSHLEN RDAFIERHIG PGVDQQQEML RTVGADSLDA LISQIVPADI    50
    QLATPPDVGD AATEFAALAE LKAIAGRNKR FKNYIGMGYT AVHTPPVILR 100
    NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTLDLTGL DIASASLLDE 150
    ATAAAEAMAM AKRVSKLKNA NRFFVAADVH PQTLDVVRTR AETFGFEVIV 200
    DDAPKALDHQ DLFGVLLQQV GTTGEVHDYR ELISELKSRK VIVSVAADFM 250
    ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAS DEFKRSMPGR 300
    IIGVSKDAAG RTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
    FHGPAGLKRI ASRIHRFADI LAAGLQHKGL KLRHATWFDT LCVEVADKAT 400
    VLARAEASEI NLRSDIPGAV GITLDETTTR ADVQALLRVV TGEDATFDID 450
    ALDKEVAHDS RSIPAAMLRD DAILTHPVFN RYHSETEMMR YMHSLERKDL 500
    ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPAD QAEGYLQMIS 550
    QLSDWLVKLT GYDALCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 600
    PSSAHGTNPA SAQMAGMQVV VVACDKQGNI DLADLRAKAE TAGDKLSCIM 650
    VTYPSTHGVY EETIREVCDI VHQYGGQVYL DGANMNAQVG ITSPGYIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIEGMLTSQG 750
    AVSAAPFGSA SILPISWMYI RMMGSQGLKK ASQTAILNAN YIASRLKDAY 800
    PVLYTGRDGR VAHECILDIR PLKEATGISE LDIAKRLIDY GFHAPTMSFP 850
    VAGTLMVEPT ESESKVELDR FIDAMLAIRG EIDRVAQGEW PQDDNPLVNA 900
    PHVQRELAQE WEHAYSRELA AFPAGFENKY WPTVKRLDDV YGDRNLFCSC 950
    VPMSEYQ 957
    Length:957
    Mass (Da):104,444
    Last modified:October 2, 2007 - v1
    Checksum:i892D2C190C21BE41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75723.1.
    RefSeqiWP_012123849.1. NC_009778.1.
    YP_001436560.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU75723; ABU75723; ESA_00426.
    GeneIDi5549571.
    KEGGiesa:ESA_00426.
    PATRICi20393136. VBICroSak107175_0389.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75723.1 .
    RefSeqi WP_012123849.1. NC_009778.1.
    YP_001436560.1. NC_009778.1.

    3D structure databases

    ProteinModelPortali A7MR85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_00426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU75723 ; ABU75723 ; ESA_00426 .
    GeneIDi 5549571.
    KEGGi esa:ESA_00426.
    PATRICi 20393136. VBICroSak107175_0389.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-422-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894.

    Entry informationi

    Entry nameiGCSP_CROS8
    AccessioniPrimary (citable) accession number: A7MR85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3