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A7MR85 (GCSP_CROS8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:ESA_00426
OrganismCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]
Taxonomic identifier290339 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045583

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A7MR85 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 892D2C190C21BE41

FASTA957104,444
        10         20         30         40         50         60 
MTQTLSHLEN RDAFIERHIG PGVDQQQEML RTVGADSLDA LISQIVPADI QLATPPDVGD 

        70         80         90        100        110        120 
AATEFAALAE LKAIAGRNKR FKNYIGMGYT AVHTPPVILR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQVTLDLTGL DIASASLLDE ATAAAEAMAM AKRVSKLKNA NRFFVAADVH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFEVIV DDAPKALDHQ DLFGVLLQQV GTTGEVHDYR ELISELKSRK 

       250        260        270        280        290        300 
VIVSVAADFM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFAAS DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDAAG RTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV FHGPAGLKRI 

       370        380        390        400        410        420 
ASRIHRFADI LAAGLQHKGL KLRHATWFDT LCVEVADKAT VLARAEASEI NLRSDIPGAV 

       430        440        450        460        470        480 
GITLDETTTR ADVQALLRVV TGEDATFDID ALDKEVAHDS RSIPAAMLRD DAILTHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YMHSLERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPAD 

       550        560        570        580        590        600 
QAEGYLQMIS QLSDWLVKLT GYDALCMQPN SGAQGEYAGL LAIRHYHESR NEGHRDICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMQVV VVACDKQGNI DLADLRAKAE TAGDKLSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCDI VHQYGGQVYL DGANMNAQVG ITSPGYIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHSVV QIEGMLTSQG AVSAAPFGSA SILPISWMYI RMMGSQGLKK 

       790        800        810        820        830        840 
ASQTAILNAN YIASRLKDAY PVLYTGRDGR VAHECILDIR PLKEATGISE LDIAKRLIDY 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESKVELDR FIDAMLAIRG EIDRVAQGEW PQDDNPLVNA 

       910        920        930        940        950 
PHVQRELAQE WEHAYSRELA AFPAGFENKY WPTVKRLDDV YGDRNLFCSC VPMSEYQ 

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References

[1]"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-894.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000783 Genomic DNA. Translation: ABU75723.1.
RefSeqYP_001436560.1. NC_009778.1.

3D structure databases

ProteinModelPortalA7MR85.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290339.ESA_00426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU75723; ABU75723; ESA_00426.
GeneID5549571.
KEGGesa:ESA_00426.
PATRIC20393136. VBICroSak107175_0389.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycCSAK290339:GJ80-422-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_CROS8
AccessionPrimary (citable) accession number: A7MR85
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families