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Protein

UDP-N-acetyl-D-mannosaminuronic acid transferase

Gene

wecG

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol.UniRule annotation

Pathwayi: enterobacterial common antigen biosynthesis

This protein is involved in the pathway enterobacterial common antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway enterobacterial common antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00566.

Protein family/group databases

CAZyiGT26. Glycosyltransferase Family 26.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosaminuronic acid transferaseUniRule annotation (EC:2.4.1.180UniRule annotation)
Short name:
UDP-ManNAcA transferaseUniRule annotation
Gene namesi
Name:wecGUniRule annotation
Synonyms:rffMUniRule annotation
Ordered Locus Names:ESA_03765
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188591 – 247UDP-N-acetyl-D-mannosaminuronic acid transferaseAdd BLAST247

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_03765.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 26 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UHC. Bacteria.
COG1922. LUCA.
HOGENOMiHOG000075380.
KOiK02852.
OMAiMRDCRKV.

Family and domain databases

CDDicd06533. Glyco_transf_WecG_TagA. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_01001. WecG_RffM. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR023085. UDP-ManNAcA_Trfase_WecG.
IPR004629. WecB_TagA_CpsF.
[Graphical view]
PfamiPF03808. Glyco_tran_WecB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00696. wecG_tagA_cpsF. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MQI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSEQVTAPV YTLRGLPLLG WRDMQHALDY LYADGSLRHG TLVAINAEKM
60 70 80 90 100
LALEADAEVR SLIEAAEFKY ADGISVVRSV RKKYPQAKVS RVAGADLWEA
110 120 130 140 150
LMARAGREGT PVFLVGGKPQ VLAQTIEKLK RQWNVNIVDA QDGYFKPEER
160 170 180 190 200
AALFARIRDS GAQIVTVAMG SPRQEIFMRD CRLVHPDALY MGVGGTYDVF
210 220 230 240
TGHVKRAPKA WQNLGLEWLY RLLSQPSRLK RQLRLLRYLG WHYTGRL
Length:247
Mass (Da):27,930
Last modified:October 2, 2007 - v1
Checksum:iBF90B09336873988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78957.1.

Genome annotation databases

EnsemblBacteriaiABU78957; ABU78957; ESA_03765.
KEGGiesa:ESA_03765.
PATRICi20399211. VBICroSak107175_3346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78957.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_03765.

Protein family/group databases

CAZyiGT26. Glycosyltransferase Family 26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU78957; ABU78957; ESA_03765.
KEGGiesa:ESA_03765.
PATRICi20399211. VBICroSak107175_3346.

Phylogenomic databases

eggNOGiENOG4108UHC. Bacteria.
COG1922. LUCA.
HOGENOMiHOG000075380.
KOiK02852.
OMAiMRDCRKV.

Enzyme and pathway databases

UniPathwayiUPA00566.

Family and domain databases

CDDicd06533. Glyco_transf_WecG_TagA. 1 hit.
Gene3Di3.40.30.10. 1 hit.
HAMAPiMF_01001. WecG_RffM. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
IPR023085. UDP-ManNAcA_Trfase_WecG.
IPR004629. WecB_TagA_CpsF.
[Graphical view]
PfamiPF03808. Glyco_tran_WecB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00696. wecG_tagA_cpsF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWECG_CROS8
AccessioniPrimary (citable) accession number: A7MQI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.