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A7MQI3 (GPPA_CROS8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:ESA_03778
OrganismCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]
Taxonomic identifier290339 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000314493

Sequences

Sequence LengthMass (Da)Tools
A7MQI3 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 93EB6216DE0729E1

FASTA49454,237
        10         20         30         40         50         60 
MPGTPSLYAA IDLGSNSFHM LVVREVAGSI QTLTRVKRKV RLAAGLGADN ALSADAMERG 

        70         80         90        100        110        120 
WQCLRLFAER LQDIPPSQIR VVATATLRLA TNADVFVARA QEILGCPVQV IAGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG ADRRLVVDIG GASTELVTGT GARATSLFSL PMGCVTFLER FFTDRSLTQE 

       190        200        210        220        230        240 
HFASAEQAAR DILQPVIAQL RGQGWKICVG ASGTVQALQE IMMAQGMDER ITLAKLQQLK 

       250        260        270        280        290        300 
ARAIHCGRLE ELEIEGLTLE RALVFPSGLA ILIAIFSELE IECMTLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLAVDQDIRN RTLKNIQRRF MVDIAQAGRV AQLAERFAVS VEREWALDDL SRALLHSASL 

       370        380        390        400        410        420 
LHEVGLAVDF KRAPQHAAYL VNNLDLPGFT PAQKKLLATL LLNQTGTVDL PALQQQNAVP 

       430        440        450        460        470        480 
LRVAERLCRL LRLAIIFASR RRDDMLPDVT LTAHDDTLTA SLPQDWLSVH PLGAEMLEQE 

       490 
QLWQSYVHWQ LDVK 

« Hide

References

[1]"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-894.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000783 Genomic DNA. Translation: ABU78970.1.
RefSeqYP_001439806.1. NC_009778.1.

3D structure databases

ProteinModelPortalA7MQI3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290339.ESA_03778.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU78970; ABU78970; ESA_03778.
GeneID5548290.
KEGGesa:ESA_03778.
PATRIC20399237. VBICroSak107175_3359.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycCSAK290339:GJ80-3767-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_CROS8
AccessionPrimary (citable) accession number: A7MQI3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways