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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

ESA_04093

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (ESA_04093)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (ESA_04093)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotation, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Ordered Locus Names:ESA_04093Imported
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)Imported
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_04093.

Structurei

3D structure databases

ProteinModelPortaliA7MQ94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 177FlavoproteinInterPro annotationAdd BLAST172
Domaini187 – 368DFPInterPro annotationAdd BLAST182

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
HOGENOMiHOG000037526.
KOiK13038.
OMAiVRFIGNH.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MQ94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLAGKKIVL GVSGGIAAYK TPELVRRLRE RGAEVRVAMT EAAKAFITPL
60 70 80 90 100
SLQAVSGYPV SDSLLDPAAE AAMGHIELGK WADLVILAPA TADLIARVAA
110 120 130 140 150
GMANDLVTTI CLATPSPVAV VPAMNQQMYR NIATQQNIER LASRGLRIWG
160 170 180 190 200
PDSGSQACGD VGPGRMLDPL EIVELAANHF APVNDLQHLN IMITAGPTRE
210 220 230 240 250
RLDPVRYITN DSSGKMGFAI AAAASARGAR VTLVAGPVAL PTPPGVERID
260 270 280 290 300
VESALEMEAA VQQRAQQQQI FIGCAAVADY RAETISSEKI KKQGDELTLK
310 320 330 340 350
MVKNPDIVAG VAALSQNRPY VVGFAAETNN VEEYARQKRQ RKNLDLICAN
360 370 380 390 400
DVSQAGHGFN SDTNALHLFW QEGDKVLPLE RKALLGQRLL DEIVTRYDEK

NRR
Length:403
Mass (Da):43,331
Last modified:October 2, 2007 - v1
Checksum:iBB2FDF6F427F995C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU79274.1.
RefSeqiWP_007853094.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU79274; ABU79274; ESA_04093.
KEGGiesa:ESA_04093.

Similar proteinsi

Entry informationi

Entry nameiA7MQ94_CROS8
AccessioniPrimary (citable) accession number: A7MQ94
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported