A7MQ68 (CDH_CROS8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol pyrophosphatase
EC=3.6.1.26

Alternative name(s):
CDP-diacylglycerol phosphatidylhydrolase
CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	ESA_04129

Organism

Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity HAMAP MF_00319.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_1000019263
Regions
	Transmembrane	5 – 27	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A7MQ68 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: F2177996964F1B48	FASTA	255	28,840
	10 20 30 40 50 60 MKRALLITVA LIAVLALTTL VAWRYLFPHD PDALRHIVMQ QCLPGERERQ EPAPCAQVNL 70 80 90 100 110 120 PAGYVVLKDI NGPLQYLLMP TWKINGVESP LLLSDNTPNF FWQAWQARRW MSEKRGSPVP 130 140 150 160 170 180 DSAVSLTINS RMGRSQNHFH IHISCLRPDV RAQLDAAMNA IGSRWQPFPG SLRGHDYLAR 190 200 210 220 230 240 RVSGEELSRR SPFMMLAEEV PQAREHMGRY SLALAPLKDG AFVLLATQRQ LLQFNLAHSE 250 ELQDHDCALL HEGTP

References

[1]

"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species." Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J. PLoS ONE 5:E9556-E9556(2010) [PubMed: 20221447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-894.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000783 Genomic DNA. Translation: ABU79310.1.
RefSeq	YP_001440146.1. NC_009778.1.
3D structure databases
ProteinModelPortal	A7MQ68.
SMR	A7MQ68. Positions 32-250.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MQ68.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5549581.
GenomeReviews	Gene locus ESA_04129 in contig CP000783_GR.
KEGG	esa:ESA_04129.
PATRIC	20399881. VBICroSak107175_3670.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2134.
HOGENOM	HBG565233.
OMA	DINGPLQ.
ProtClustDB	PRK05471.
Family and domain databases
HAMAP	MF_00319. Cdh. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase. [Graphical view]
KO	K01521.
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_CROS8

Accession

Primary (citable) accession number: A7MQ68

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program