Reviewed, UniProtKB/Swiss-Prot A7MPR2 (UXAB_ENTS8)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	ESA_01824

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD(+) = D-tagaturonate + NADH.
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion.
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase		PRO_1000044705
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7MPR2-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 290D81D64C61243C	FASTA	483	54,430
	10 20 30 40 50 60 MKTLNRRDFP GALWPERIIQ FGEGNFLRAF IDWQVDLLNE HTDLNAGVVV VRPIASDFPP 70 80 90 100 110 120 SLSTQDGLYT TIIRGLNEKG EAVSESRLIR SVNREISVYA QYDEFLKLAH NPDIRFVFSN 130 140 150 160 170 180 TTEAGISYHA GDQFDDAPAV SYPAKLTRLL FERFSHFDGA QDKGWVIIPC ELIDYNGEAL 190 200 210 220 230 240 RELVLRYAHE WALPAAFTTW LESANSFCST LVDRIVTGYP RDEVAQLEES LGYHDAFLDT 250 260 270 280 290 300 AEHFYLFVIQ GPQWLARELR LDKLPLNVLI VDDIKPYKAR KVAILNGAHT ALVPVAFLAG 310 320 330 340 350 360 LNTVGEAMND AQICAFVERA IHDEIIPVLD LPRNELESFA DAVVSRFRNP YIKHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLAGQA QMGTLPPRLT FALAALIAFY RGERNGEGYP LQDDAHWLAR 430 440 450 460 470 480 FEQLWTQRGD NTITLRELVD AVLSDCEHWE QDLTAVPGLA AQVTRDLDAI LNQGMRHAVA PLC

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000783 Genomic DNA. Translation: ABU77078.1.
RefSeq	YP_001437914.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5550959.
GenomeReviews	Gene locus ESA_01824 in contig CP000783_GR.
KEGG	esa:ESA_01824.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_ENTS8

Accession

Primary (citable) accession number: A7MPR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)