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A7MPE8

- FMT_CROS8

UniProt

A7MPE8 - FMT_CROS8

Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

    Catalytic activityi

    10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

    GO - Molecular functioni

    1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
    2. methyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-35-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
    Gene namesi
    Name:fmtUniRule annotation
    Ordered Locus Names:ESA_00038
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Methionyl-tRNA formyltransferasePRO_1000020060Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290339.ESA_00038.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MPE8.
    SMRiA7MPE8. Positions 2-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni113 – 1164Tetrahydrofolate (THF) bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the Fmt family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0223.
    HOGENOMiHOG000261177.
    KOiK00604.
    OMAiEARINWK.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.
    PROSITEiPS00373. GART. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MPE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESLRIIFA GTPDFAARHL DALLSSSHQV VGVFTQPDRP AGRGKKLMPG    50
    PVKVLAQEND IPVFQPKSLR SAENQELVAA LNADVMVVVA YGLILPEAVL 100
    SMPRLGCINV HGSLLPRWRG AAPIQRSLWA GDAETGVTIM QMDKGLDTGD 150
    MLRKLSCPIT ADDTSASLYD KLAQLGPQGL LATLEDLAAG RAVPEKQDDA 200
    QATYADKLSK EEARLDWTLS AAQLERCIRA FNPWPVSFFM IDEQPVKVWK 250
    ASVIRQQSHA TPGTILDAGK QGIQVATTDG ILNLESLQPA GKKPMSAQDL 300
    LNSRREWFTP GAILA 315
    Length:315
    Mass (Da):34,084
    Last modified:October 2, 2007 - v1
    Checksum:i42C263EA3F2AB1CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75347.1.
    RefSeqiYP_001436183.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU75347; ABU75347; ESA_00038.
    GeneIDi5548819.
    KEGGiesa:ESA_00038.
    PATRICi20392407. VBICroSak107175_0036.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75347.1 .
    RefSeqi YP_001436183.1. NC_009778.1.

    3D structure databases

    ProteinModelPortali A7MPE8.
    SMRi A7MPE8. Positions 2-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_00038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU75347 ; ABU75347 ; ESA_00038 .
    GeneIDi 5548819.
    KEGGi esa:ESA_00038.
    PATRICi 20392407. VBICroSak107175_0036.

    Phylogenomic databases

    eggNOGi COG0223.
    HOGENOMi HOG000261177.
    KOi K00604.
    OMAi EARINWK.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-35-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    PROSITEi PS00373. GART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894.

    Entry informationi

    Entry nameiFMT_CROS8
    AccessioniPrimary (citable) accession number: A7MPE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3