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Protein

Isocitrate dehydrogenase kinase/phosphatase

Gene

aceK

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.UniRule annotation

Catalytic activityi

ATP + [isocitrate dehydrogenase (NADP+)] = ADP + [isocitrate dehydrogenase (NADP+)] phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei337ATPUniRule annotation1
Active sitei372UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi316 – 322ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Protein phosphatase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase kinase/phosphataseUniRule annotation (EC:2.7.11.5UniRule annotation, EC:3.1.3.-UniRule annotation)
Short name:
IDH kinase/phosphataseUniRule annotation
Short name:
IDHK/PUniRule annotation
Gene namesi
Name:aceKUniRule annotation
Ordered Locus Names:ESA_00055
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003152641 – 596Isocitrate dehydrogenase kinase/phosphataseAdd BLAST596

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_00055.

Family & Domainsi

Sequence similaritiesi

Belongs to the AceK family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105VS7. Bacteria.
COG4579. LUCA.
HOGENOMiHOG000247673.
KOiK00906.
OMAiEPWYSVG.

Family and domain databases

HAMAPiMF_00747. AceK. 1 hit.
InterProiIPR010452. Isocitrate_DH_AceK.
[Graphical view]
PfamiPF06315. AceK. 1 hit.
[Graphical view]
PIRSFiPIRSF000719. AceK. 1 hit.
ProDomiPD043552. Isocitrate_DH_AceK. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

A7MPD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRGLELLI AQTILQGFDA QYGRFLEITA GAQHRFEQAD WHAVQQAMKS
60 70 80 90 100
RIHLYDHHVG LVVEQLRCIM EGKATDPDFL LRVKRHYTDL LPDYPRFEIA
110 120 130 140 150
ESFFNSVYCR LYDHRSLTPD RLFIFSSQPE RRFRTMPRPL AKNFFPEQGW
160 170 180 190 200
QPLLTTLLTD LPLRLPWQDL ARDVRYIIAH LNETLGPARL AQAHLEMANE
210 220 230 240 250
LFYRNKAAWL VGKLRLPDAT LPFLLPVHRS DDGELFVDTC LTGSAGASIV
260 270 280 290 300
FGFARSYFMV YAPLPAALVE WLREILPGKT TAELYMAIGC QKHAKTESYR
310 320 330 340 350
EYLHYLRHAD EQFIEAPGIR GMVMLVFTLP GFDRVFKVIK DRFAPQKEMS
360 370 380 390 400
EAHVRACYQL VKEHDRVGRM ADTQEFENFV IEKRRISPEL MALLQQEVGQ
410 420 430 440 450
KLTDMGDKIS ISHLYIERRM VPLNIWLEQA TGQQLRDAIE EYGNAIRQLA
460 470 480 490 500
AANIFPGDML FKNFGVTRHG RVVFYDYDEI CYMTEVNFRD IPPPRYPEDE
510 520 530 540 550
LSAEPWYSVA PGDVFPEEFR HWLCADPKIG PLFEEMHSDL FSASYWRALQ
560 570 580 590
TRIREGYVED VYAYRRRQRF CVRWKNHNGH PEAAVSAIAP SAVGEG
Length:596
Mass (Da):69,185
Last modified:October 2, 2007 - v1
Checksum:iB28E23C061AEC6B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU75360.1.
RefSeqiWP_012123597.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU75360; ABU75360; ESA_00055.
GeneIDi5548932.
KEGGiesa:ESA_00055.
PATRICi20392441. VBICroSak107175_0048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU75360.1.
RefSeqiWP_012123597.1. NC_009778.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_00055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU75360; ABU75360; ESA_00055.
GeneIDi5548932.
KEGGiesa:ESA_00055.
PATRICi20392441. VBICroSak107175_0048.

Phylogenomic databases

eggNOGiENOG4105VS7. Bacteria.
COG4579. LUCA.
HOGENOMiHOG000247673.
KOiK00906.
OMAiEPWYSVG.

Family and domain databases

HAMAPiMF_00747. AceK. 1 hit.
InterProiIPR010452. Isocitrate_DH_AceK.
[Graphical view]
PfamiPF06315. AceK. 1 hit.
[Graphical view]
PIRSFiPIRSF000719. AceK. 1 hit.
ProDomiPD043552. Isocitrate_DH_AceK. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiACEK_CROS8
AccessioniPrimary (citable) accession number: A7MPD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.