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A7MPB4

- NUOH_CROS8

UniProt

A7MPB4 - NUOH_CROS8

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Protein
NADH-quinone oxidoreductase subunit H
Gene
nuoH, ESA_00938
Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-932-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit H (EC:1.6.99.5)
    Alternative name(s):
    NADH dehydrogenase I subunit H
    NDH-1 subunit H
    Gene namesi
    Name:nuoH
    Ordered Locus Names:ESA_00938
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei81 – 10121Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei114 – 13421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei154 – 17421Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei186 – 20621Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei237 – 25721Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei265 – 28521Helical; Reviewed prediction
    Add
    BLAST
    Transmembranei302 – 32221Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326NADH-quinone oxidoreductase subunit HUniRule annotation
    PRO_1000067744Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

    Protein-protein interaction databases

    STRINGi290339.ESA_00938.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1005.
    HOGENOMiHOG000228276.
    KOiK00337.
    OMAiGAFRNFA.
    OrthoDBiEOG6B62B4.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MPB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWLTPDVIE ILLSILKAVV ILLVVVSCGA FMSFGERRLL GLFQNRYGPN    50
    RVGWGGSLQL VADMIKMFFK EDWIPRFSDR VIFTLAPMIA FTSLLLAFAI 100
    VPVSPTWVVA DLNIGILFFL MMAGLGVYAV LFAGWSSNNK YSLLGAMRAS 150
    AQTLSYEVFL GLSLMGVVAQ AGSFNMTDIV NNQAHLWNVI PQFFGFITFA 200
    IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG EYIGIVTVSA 250
    LIVTLFFGGW QGPWLPPFIW FALKTAFFMM MFILIRAALP RPRYDQVMSF 300
    GWKVCLPLTL INLLVTAAVI LWQTAA 326
    Length:326
    Mass (Da):36,331
    Last modified:October 2, 2007 - v1
    Checksum:i4E8AF4D21687BFE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU76208.1.
    RefSeqiYP_001437044.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU76208; ABU76208; ESA_00938.
    GeneIDi5552247.
    KEGGiesa:ESA_00938.
    PATRICi20394071. VBICroSak107175_0836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU76208.1 .
    RefSeqi YP_001437044.1. NC_009778.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_00938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU76208 ; ABU76208 ; ESA_00938 .
    GeneIDi 5552247.
    KEGGi esa:ESA_00938.
    PATRICi 20394071. VBICroSak107175_0836.

    Phylogenomic databases

    eggNOGi COG1005.
    HOGENOMi HOG000228276.
    KOi K00337.
    OMAi GAFRNFA.
    OrthoDBi EOG6B62B4.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-932-MONOMER.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894.

    Entry informationi

    Entry nameiNUOH_CROS8
    AccessioniPrimary (citable) accession number: A7MPB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 2, 2007
    Last modified: May 14, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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