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Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-932-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit HUniRule annotation
NDH-1 subunit HUniRule annotation
Gene namesi
Name:nuoHUniRule annotation
Ordered Locus Names:ESA_00938
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei81 – 10121HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei154 – 17421HelicalUniRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalUniRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalUniRule annotationAdd
BLAST
Transmembranei265 – 28521HelicalUniRule annotationAdd
BLAST
Transmembranei302 – 32221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326NADH-quinone oxidoreductase subunit HPRO_1000067744Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_00938.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
KOiK00337.
OMAiWRQPVGF.
OrthoDBiEOG6B62B4.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWLTPDVIE ILLSILKAVV ILLVVVSCGA FMSFGERRLL GLFQNRYGPN
60 70 80 90 100
RVGWGGSLQL VADMIKMFFK EDWIPRFSDR VIFTLAPMIA FTSLLLAFAI
110 120 130 140 150
VPVSPTWVVA DLNIGILFFL MMAGLGVYAV LFAGWSSNNK YSLLGAMRAS
160 170 180 190 200
AQTLSYEVFL GLSLMGVVAQ AGSFNMTDIV NNQAHLWNVI PQFFGFITFA
210 220 230 240 250
IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG EYIGIVTVSA
260 270 280 290 300
LIVTLFFGGW QGPWLPPFIW FALKTAFFMM MFILIRAALP RPRYDQVMSF
310 320
GWKVCLPLTL INLLVTAAVI LWQTAA
Length:326
Mass (Da):36,331
Last modified:October 2, 2007 - v1
Checksum:i4E8AF4D21687BFE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU76208.1.
RefSeqiYP_001437044.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU76208; ABU76208; ESA_00938.
GeneIDi5552247.
KEGGiesa:ESA_00938.
PATRICi20394071. VBICroSak107175_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU76208.1.
RefSeqiYP_001437044.1. NC_009778.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_00938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU76208; ABU76208; ESA_00938.
GeneIDi5552247.
KEGGiesa:ESA_00938.
PATRICi20394071. VBICroSak107175_0836.

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
KOiK00337.
OMAiWRQPVGF.
OrthoDBiEOG6B62B4.

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-932-MONOMER.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894.

Entry informationi

Entry nameiNUOH_CROS8
AccessioniPrimary (citable) accession number: A7MPB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.