Reviewed, UniProtKB/Swiss-Prot A7MNV8 (ASTD_ENTS8)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	ESA_02155

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000065757
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	277	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7MNV8-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 71E87D01B57FE4BC	FASTA	492	52,433
	10 20 30 40 50 60 MSLWINGEWT TGQGEALEKR DPVGSGLLWQ GHAADDAQVQ AACAAARAAF PAWAKRPFAD 70 80 90 100 110 120 RQAIAEKFAA LLEANKTELT RIIALETSKP RWEAATEVTA MINKVGISLK AYQTRTGEQH 130 140 150 160 170 180 SPMPDGAATL RHRPHGVLAV FGPYNFPGHL PNGHIVPALL AGNTLVFKPS ELTPHTGEAV 190 200 210 220 230 240 MKLWEQAGLP AGVLNLVQGA RATGQALSAR PELDGLLFTG SAGTGYQLHR QLAGQPEKIL 250 260 270 280 290 300 ALEMGGNNPL IVEDPDDIDG AVHLAIQSAF ITAGQRCTCA RRLLVKRGAA GDAFLARLVE 310 320 330 340 350 360 IAGRLRPDRW DAEPQPFMGG LISAQAAERV LEAWQGHLSR GGKPLLTPAL VQAGSSLLTP 370 380 390 400 410 420 GIIELTGVRD VPDEEVFGPL LGVWRYDDFD EAITLANATR YGLSCGLISP VREKFDQLLL 430 440 450 460 470 480 EARAGIVNWN KPLTGAASTA PFGGVGASGN HRPSAWYAAD YCAWPMASLE SPTFALPQTL 490 NPGLDFSGKE QA

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000783 Genomic DNA. Translation: ABU77404.1.
RefSeq	YP_001438240.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5550034.
GenomeReviews	Gene locus ESA_02155 in contig CP000783_GR.
KEGG	esa:ESA_02155.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_ENTS8

Accession

Primary (citable) accession number: A7MNV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 2, 2007
Last modified:	November 25, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)