Reviewed, UniProtKB/Swiss-Prot A7MN58 (PQQC_ENTS8)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	ESA_02994

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H(2)O(2) + 2 H(2)O.
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Pyrroloquinoline-quinone synthase		PRO_1000061668

Sequences

	Sequence		Length	Mass (Da)
	A7MN58-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 60024EFC6E018056	FASTA	251	29,395
	10 20 30 40 50 60 MTEQRLLTPD EFEAALRAKG AFYHIHHPYH IAMHNGEATR EQIQGWVANR FYYQTSIPIK 70 80 90 100 110 120 DAAIMANCPH PEVRRQWVQR ILDHDGYDGS EGGIEAWLRL GEAVGLSRES LLSEERVLPG 130 140 150 160 170 180 VRFAVDAYVN FARRACWEEA ACSSLTELFA PQIHQARLDS WPQHYTWIEA EGYDYFRSRL 190 200 210 220 230 240 NQARRDVEHG LSLALEYCNT MERQQRMLEI LQFKLDILWS MLDAMTMAYT LDRAPYHTVT 250 REAVWHKRRL V

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000783 Genomic DNA. Translation: ABU78223.1.
RefSeq	YP_001439059.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5548763.
GenomeReviews	Gene locus ESA_02994 in contig CP000783_GR.
KEGG	esa:ESA_02994.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_ENTS8

Accession

Primary (citable) accession number: A7MN58

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 2, 2007
Last modified:	November 4, 2008
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)